The invention discloses a bridge crane reliability optimization design method which comprises the following steps: S1, defining uncertain structure parameters in a crane, and describing the uncertainparameters as interval variables; S2, establishing a limit state function according to the structural failure form, and solving a reliability index in the optimization model by adopting a Vparalove function in MATLAB based on an interval analysis method; S3, introducing a non-probabilistic reliability index, and establishing a non-probabilistic reliability optimization design model by taking a given required reliability index as a constraint condition; S4, solving an optimization problem;. According to the method, the reliability index can be effectively, quickly and accurately solved; Secondly, the common defects of low iteration rate, low optimization precision, large storage space and the like of an optimization algorithm in the actual solving process are considered; On the basis of researching a traditional moth flame algorithm, the method is effectively improved, and the convergence rate and the convergence precision of the outer layer optimizer are remarkably improved. And the method has an important value in structural reliability optimization design in engineering practice.