The invention discloses an isolated semi-quasi Z-source DC boost converter, and belongs to the technical field of power generation, power transformation or power distribution. The circuit comprises a first-stage booster circuit composed of a first inductor, a fourth diode, a fourth capacitor and a fifth diode, a second-stage booster circuit composed of a second inductor, a first capacitor, a first diode and a three-switch inverter, and an output circuit composed of a transformer, a second capacitor, a third capacitor, a second diode, a third diode and a load. The whole circuit is simple in structure, the power supply input current is continuous, the buck-boost characteristic of a semi-quasi Z-source network is combined, the circuit has higher output voltage gain, load current is continuous, and the circuit has straight-through and open-circuit immunity, can work in a straight-through state, and does not have starting impact current and impact current at the switching-on moment of a switching tube.