30 results about "Molecular Computers" patented technology

A device, system and method for molecular computing which not only includes a suitable, renewable power source, but actually is able to receive power through the performance of the computations themselves. The molecular computing machine of the present invention actually employs the free-energy difference between its input and output to accomplish a computation, preferably by using its input DNA molecule as a partial source of energy, or alternatively by using the input DNA molecule as the sole source of energy. This molecular finite automaton preferably transforms an input DNA molecule into an output DNA molecule by digesting the input as it computes.

The invention discloses a computer aided design system for predicting energetic molecules based on machine learning performance, and belongs to the technical field of computer aided design systems. The system comprises: a molecule rapid generation module, which is used for generating all possible molecular structural formulas according to permutation and combination of a molecular mother ring anda substituent group input by a user, and removing a repeated structure; a molecular data set module used for recording reported energetic molecular performance data, and the energetic molecular performance data being mainly used as a training set of the machine learning model training module; a molecular descriptor generation module used for calculating molecular descriptors of molecules generatedby the molecular rapid generation module or molecules in the molecular data set module or molecules input by a user; a machine learning model training module used for training and storing a model byadopting a machine learning algorithm according to the data of the molecular descriptor set; and a performance prediction module used for reading the model and carrying out performance prediction on the molecules generated by the molecule rapid generation module or the molecules input by the user.

The invention relates to a tristable RS trigger capable of supporting the multiple value logic and belongs to the technical field of digital circuits. The tristable RS trigger capable of supporting the multiple value logic comprises three NAND gates (G1, G2 and G3) and two AND gates (AND1 and AND2), wherein two inputs of the tristable RS trigger are S and R, and two outputs of the tristable RS trigger are Q and N; the inputs of four input ends of the G3 are S, R, Q and N respectively; three input ends of the G1 are respectively connected with the output end of the G3, the S and the output end of the AND2; three input ends of the G2 are respectively connected with the output end of the G3, the R and the output end of the AND1; two input ends of the AND1 are connected with the output Q of the G1, and two input ends of the AND2 are connected with the output N of the G2. The tristable RS trigger can obtain 01, 10 and 11 stable states and realize the multiple value logic, is simple in structure and practical, and can be used for providing a technical support for a molecular computer based on a digital circuit.

An autonomous molecular computer that, when coupled to a molecular model of a disease, is capable of disease diagnosis. The computer preferably performs such diagnosis by detecting one or more disease markers. For example, optionally and preferably the molecular computer checks for the presence of over-expressed, under-expressed and mutated genes, applies programmed medical knowledge to this information to reach a diagnostic decision.

A DNA molecular computer of miniflow control chip consists of operation media formed by DNA molecule, DNA molecular operator using miniflow control chip as operating platform, DNA molecular storage using DNA molecule as storing media and using miniflow control chip as operating platform, controller using electronic computer and detector as core. It features that controller is connected separately to DNA molecular operator and to electrode on miniflow control chip of DNA molecular storage.

The present invention relates to computer science, molecular biology and microfluidics technique which provides a DNA molecular computer based on microfluidic chip. The objective is to provide a DNA molecular computer which uses the microfluidic chip as a operation platform, mainly including: using DNA molecules as operation media, using the microfluidic chip as the operation platform of a DNA molecular operator; using DNA molecules as storage media, using the microfluidic chip as the operation platform of a DNA molecular storage; using a electronic computer and a detector as the kernel of a controller; said microfluidic chip includes a DNA molecular computation region and a DNA molecular storage region. The microfluidic chip consists of digestion, ligation, PCR amplification and chip electrophoresis unit connected by microchannels in turn, and carries out the liquid control through micropumps and microvalves.

An electrically reversible molecular electronic device based on scanning tunnel microtechnique is composed of substrate with an electrically conductive surface having molecular-class smoothness, an organic molecular layer which is a vertically orientated single molecular layer, and the probe which is the needle tip in scanning tunnel microscope. At the action of positive and negative pulses, its states can be reverisibly switched.

The invention is a microflow control chip for DNA molecular computer, characterized in that: it is integrated with DNA molecular operator and DNA molecular memory. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.

The invention relates to synthesis, preparation and application of a fluorescent probe for identifying Cys, GSH and HOCl on the basis of a molecular logic gate, belongs to the field of small-moleculefluorescent probes and relates to the technical field of molecular computers. The multi-identification fluorescent has a structural formula as shown in a formula (I): ( as shown in the description). The novel fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time, has the advantages of low detection limit, high sensitivity and highselectivity and can realize visible detection; the probe adopts cheap and easily available raw materials, high yield and low preparation cost, and is suitable for industrialized production; a to-be-detected liquid is a buffer solution of 100 percent and is consistent with the buffer ability of the physiological environment in an organism; the molecular logic gate is built by taking the Cys, GSH and HOCl as input signals as well as taking the maximal fluorescence emitting peak fluorescent intensity in the positions of 514 nm and 412 nm as output signals; the fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time and can solve the limitation caused by the single-identification fluorescent probe.

The invention relates to a data coding method based on a four value logic circuit, and belongs to the technical field of digital circuits. By the data coding method, 2n n-digit binary numbers can be generated. Specifically, 2n registers are used in the method. Under the action of a synchronous clock, to-be-output 2n n-digit binary numbers are set to be paralleled to the corresponding registers according to input and output formulas to obtain 2n n-digit binary integers. The data coding method having the advantage of high parallelism is a basis of research on integrated-circuit based molecular computers.

The invention is a microflow control chip DNA molecular computer, comprising operation medium, reaction medium and microflow control chip, where the operation medium comprises special sequence-containing DNA calculating molecules, intermediate operating special sequence-containing DNA transfer molecules and DNA output molecules standing for calculated results; the reaction medium comprises various biochemical enzymes for endonuclease reaction and enzyme-link reaction; and the microflow control chip is provided at least with endonuclease reaction region, enzyme-link reaction region and result output region. The invention adopts the microflow control chip technique to replace the widely used test tube or surface operation in the current DNA calculating course for the first time, and provides a practical possible platform for constructing a proper DNA computer by the character that the microflow control chip operates accurately and controllably and can be integrated in high flux and large scale.

The present invention is to provide a molecular computer comprising an electronic operation section and a molecular operation section, wherein, in addition to general computation processing, said electronic operation section controls a function of the molecular operation section substantially, and the molecular operation is performed under control thereof.

The invention discloses a method for constructing a molecular semi-adder and a molecular semi-subtracter, and belongs to the technical field of molecular computers. The method is characterized in thata Cut Smart buffer solution and a plurality of DNA double chains are taken to construct a logic operation system; two kinds of incision enzymes Nb.BtsI and Nt.BbvCI are used as two paths of parallelinput signals; under the specific cutting action of the cutting endonuclease, the cutting and endonucleating are carried out. According to the half adder and the half subtracter constructed by the method, molecular devices are simple in structure, easy to implement, high in sensitivity, fast in reaction speed, obvious in reaction trend and very low in leakage rate, the output signals are easy to detect, the fluorescent signals of multiple colors clearly represent different signal outputs, and in addition, the method can also be used for accurately detecting the incision enzyme.

The invention relates to the technical fields of nanomaterials, catalysis, analytical chemistry and molecular computer, and in particular, relates to a new variable logic gate application of CoOx nanospheres based on a bovine serum protein template. The prepared CoOx nanospheres not only maintain a stable activity of electrocatalytic reduction of H2O2 in a wide pH range, but also have different influence on the activity under different pH by different metal ions. With use of the characteristic, and with metal ions as input signals, the electrochemical method is applied, the electrochemical response of the CoOx nanosphere activity of electrocatalytic reduction of H2O2 is used as an electrochemical signal, an electrochemical logic gate is constructed and the function of the logic gate is changed by adjusting pH.