36 results about "Molecular logic gate" patented technology

The invention belongs to the technical field of molecular logic gates in the industry of analytical chemistry, and relates to the construction of a label-free, high-sensitivity and high-selectivity miRNA intelligent detection method. A molecular logic gate is constructed based on silver nano-clusters and graphene oxide. According to the invention, the relative fluorescence intensity of silver nano-clusters is used as a judgment basis, when the relative fluorescence intensity is larger than 0.5, 1 is outputted. When the relative fluorescence intensity is less than 0, 0 is outputted. The molecular logic gate comprises an OR logic gate and an INHIBIT logic gate, and can be used for detecting the presence of two different miRNAs (miR-21 and miR-141) in an actual sample respectively. By adopting the logic detection method, the contents of a plurality of target analytes in a complex biological sample can be identified. Therefore, the invention has a potential application value in the aspectsof early diagnosis, multi-element detection, clinical treatment and the like for major diseases.

The invention belongs to the field of molecular computation, and particularly relates to a DNA molecular logic gate based on DNA Origami and a construction method thereof. The logic gate comprises an input signal, a signal converter and an output signal; the signal converter includes a DNA Origami template, a helper chain positioned on the DNA Origami template, and a DNA/AuNP conjugate that can be identified and connected with the helper chain; and the output signal is provided for releasing the DNA/AuNP conjugate from the DNA Origami template. According to the DNA molecular logic gate based on the DNA Origami and the construction method thereof disclosed by the invention, the selective and dynamic release to gold particles is implemented by a special DNA signal on the DNA Origami, and thus, the operation of the logic gate is implemented; moreover, by employing a gold particle dimer connected by the DNA chain, the operation of simultaneously imputing three input chains for the logic gate is implemented. The DNA molecular logic gate and the construction method thereof provide a concept to construct complex molecular circuit and nano device; and through combining with various nano engineering strategies, the DNA molecular logic gate and the construction method thereof can be used for assembling a large programmable structure, and also pave a road for sensitivity detection of various molecular conformations.

Various nanoscale logic gates are disclosed. An alternating current (“AC”) source is superimposed on a direct-current (“DC”), largely resistor-based nanoscale logic circuit in order to provide distinguishable, AC current or voltage logical output signals despite potentially narrow DC-voltage or DC-current ranges produced by the resistor-based nanoscale logic circuit. AC-enhanced AND, OR, NAND, and NOR nanoscale logic gates are provided as four specific embodiments of the present invention.

The invention discloses a DNA molecular logic gate based on DNA ribozyme and a construction method of the DNA molecular logic gate. The DNA molecular logic gate based on DNA ribozyme comprises an input signal, a DNA logic calculation unit and an output signal. In the molecular logic computing system regulated and controlled by the DNA ribozyme, the DNA ribozyme plays multiple roles of an input signal and an output report. Thus, a series of logic gates, including gates, or gates and AND gates, are successfully constructed. In addition, a more complex two-level cascade circuit and a feedback autocatalysis logic circuit are also established. The result is verified by non-denaturing polyacrylamide gel electrophoresis and real-time fluorescence detection. Through the principle design and various experimental verifications, the provided DNA ribozyme regulation and control strategy is a reasonable and feasible method for constructing a complex catalytic molecular calculation model, and may have a wider application prospect in the fields of molecular sensing, nano devices, DNA calculation and the like.

The invention discloses a 5,10,15,20-tetra-aryl diphenanthrene (9,10-b:9,10-1)-22,24-diseleno porphyrin compound which is obtained by the reaction of phenanthro-pyrrole and 2,5-di(aryl hydroxyl methyl) selenophen under low temperature and catalysis of BF3 Et2O in anaerobic atmosphere. The Soret spectral bands of the compound appear in 521nm, compared with tetraphenyl diseleno porphyrin without conjugated aromatic ring at beta-site, the Soret spectral bands are red shifted by 52nm and enter a green light zone above 500nm. The compound has wide application prospects in such areas as photodynamics therapy photosensitizer, OFETs (organic field effect tubes), molecular antenna, light energy converter, optical conversion material, molecular switch, molecular logic gate, molecular wire, organic solar battery, organic electroluminescence, non-linear optical material, optical storage, molecular identification and medicine and so on.

The invention relates to a benzoselenadiazole-based conjugated polymer used for detecting heavy metal ions or heavy metal-like ions and a preparation method and application of the conjugated polymer. The polymer has good fluorescent response on certain ions and can serve as a fluorescence sensor. In addition, due to the fluorescent response, the polymer can be used for establishing a molecular logic gate with different guest molecules, so that the polymer has good scientific research values and application potential.

The invention discloses a making method of 5, 10, 15, 20-tetrabenadiphenanthroime [9, 10-b: 9, 10-l]-22, 24-dithioporphyrin compound, which is characterized by the following: reacting phenanthroime pyrrole and 2, 5-di (phenyl hydroxy methyl) thiofuran or 2, 5-di(4-chlorphenyl hydroxy methyl) thiofuran catalyzed by BF3.Et2O under low temperature; displaying 505nm in the Soret band; making the beta-non-aromatic conjugated tetraphenyl-dithioporphyrin move 70nm than red spectrum of Soret and 51nm than middle position-tetraphenyl-2, 3, 12, 13-tetraphenyl-21, 23-dithioporphyrin of lamda max S2TPP; entering into green area over 500nm; fitting for photosensitizer, OFETs, molecular antenna, light-energy switcher, photoelectric switching material, molecular switch, molecular logic door, molecular wire, organic solar energy battery, organic electroluminescent material and non-linear optical material.

The invention discloses a method for preparing 5,10,15,20-tetra-aryl diphenanthrene (9,10-b;9,10-1)-22,24-diseleno porphyrin compound by the reaction of phenanthro-pyrrole and 2,5-di(aryl hydroxyl methyl) selenophen at low temperature with the function of BF3 Et2O under water free and oxygen free condition. The Soret spectral bands of the compound appear in 521nm, compared with tetraphenyl diseleno porphyrin without conjugated aromatic ring at beta-site, the Soret spectral bands are red shifted by 52nm and enter green light zone above 500nm. The compound has wide application prospects in such areas as photodynamics therapy photosensitizer, OFETs (organic field effect tube), molecular antenna, light energy converter, optical conversion material, molecular switch, molecular logic gate, molecular wire, organic solar battery, organic electroluminescence, non-linear optical material, optical storage, molecular identification and medicine and so on.

The invention provides a new porphyrin derivative which beta position has two different conjugated aromatic rings (phenanthrene ring and benzene ring), wherein the strong absorption band of the conjugated porphyrin derivative is above 540nm which is the center decorative porphyrin derivative with maximum adsorption wavelength heretofore, which can improve the absorption efficiency on visible light. The compound has wide application in molecule antenna, molecule logic gate, molecule wire, solar battery, optical storage, molecule recognition and photodynamic auxiliary treatment.

The invention discloses an application and a use method for 5-(2-methoxy-phenoxyl)-2, 2'-bi-pyrimidyl-4, 6-diphenol. After the tetrahydrofuran solution of the 5-(2-methoxy-phenoxyl)-2, 2'-bi-pyrimidyl-4, 6-diphenol is reacted with alkali, an ultraviolet spectrum and fluorescence spectrum are remarkably changed, the 5-(2-methoxy-phenoxyl)-2, 2'-bi-pyrimidyl-4, 6-diphenol can be applied to a pH fluorescent sensor, and the detected pH value is ranged from 6.2 to 9.9. A series of molecular logic gates based on alteration of fluorescence such as INHIBIT, NOR, COR, and the like, can be designed and constructed by using the special photochemical property of the molecular, the three basic logic gates are properly combined, and then a two input/three output complex logical system can be also constructed. The invention has high sensitivity as the pH fluorescent sensor, and the low detection limit plays the role in the microenvironment of biological tissues, cells and membranes and in the pH detection of reagent and fluid, and the like; and in the application aspect of the molecular logic gate of the optical signal, the molecular logic gate is the basic element of the chemical computer, thereby the invention has very broad application prospect and high application value.

The invention discloses a preparation method of fluorescein functionalized polydiacetylene vesicles capable of regulating and controlling colorful fluorescence emission and construction of the molecular logic gates of the fluorescein functionalized polydiacetylene vesicles, and belongs to the technical field of organic conjugated polymer wave assembly. The invention aims to solve the problems of complex preparation conditions, higher pH control requirements, low sensitivity of the functionalized base material, higher external interference and the like of the conventional fluorescence-regulatedfunctionalized base material. According to the invention, diacetylene and fluorescein groups are combined with each other to prepare the polydiacetylene composite vesicle; on the basis of the effectsof red phase and blue phase transformation of polydiacetylene under external stimulation and response of a fluorescein group to external pH value change, and a colorful fluorescence emission method for multi-stimulation of color and fluorescence emission change regulation of polydiacetylene and the fluorescein group is achieved. The composite vesicle is simple in preparation process, excellent influorescence regulation and control performance, simple and convenient in fluorescence regulation and control operation process, strong in operability, strong in environmental interference resistanceand sensitive and rapid in system response.

The invention relates to synthesis, preparation and application of a fluorescent probe for identifying Cys, GSH and HOCl on the basis of a molecular logic gate, belongs to the field of small-moleculefluorescent probes and relates to the technical field of molecular computers. The multi-identification fluorescent has a structural formula as shown in a formula (I): ( as shown in the description). The novel fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time, has the advantages of low detection limit, high sensitivity and highselectivity and can realize visible detection; the probe adopts cheap and easily available raw materials, high yield and low preparation cost, and is suitable for industrialized production; a to-be-detected liquid is a buffer solution of 100 percent and is consistent with the buffer ability of the physiological environment in an organism; the molecular logic gate is built by taking the Cys, GSH and HOCl as input signals as well as taking the maximal fluorescence emitting peak fluorescent intensity in the positions of 514 nm and 412 nm as output signals; the fluorescent probe for identifying the Cys, GSH and HOCl based on the molecular logic gate is reported for the first time and can solve the limitation caused by the single-identification fluorescent probe.

The invention discloses a pH fluorescence sensor based on a cadmium-containing coordination compound, and a preparation method thereof, and belongs to the field of chemical technology. The chemical formula of the cadmium-containing coordination compound is [Cd(2,4'-tmbpt)<2>(5-OH-bdc)]*5H<2>O. The preparation method comprises following steps: a mixture of Cd(CH<3>COO)<2>*2H<2>O, 5-hydroxy-isophthalic acid, 2,4'-tmbpt,NaOH, and water is sealed and heated in a reaction still provided with a polytetrafluoroethylene lining; after reaction, the temperature in the reaction still is reduced to room temperature at a cooling speed of 10 DEG C/h so as to obtain a colorless crystal which is the pH fluorescence sensor based on the cadmium-containing coordination compound. According to the preparation method, pH fluorescence sensing performance of the cadmium-containing coordination compound, and application research of the cadmium-containing coordination compound in the field of molecular logic gate are disclosed for the first time; repeatability is high; yield is high; product performance is stable; sensitive pH sensing properties are achieved; it is convenient to observe the change of fluorescence intensity; and molecular logic gates with INH functions can be obtained via design.

The invention relates to a DNA molecular logic gate based on nucleic acid hybridization. The invention specifically provides a DNA molecular logic gate based on nucleic acid hybridization, the DNA molecular logic gate comprises an input signal, a signal conversion unit and an output signal, the input signal comprises at least two DNA input chains; the signal conversion unit comprises: a substrate chain; the output signal comprises a nucleic acid amplification result. Based on DNA self-assembly, a simple and feasible scheme is provided for construction of a basic principle of a DNA computer.