A process for the methacrylation of dECM comprises placing a
carbonate buffer at a concentration of 1 M into a reaction vessel and heating to a temperature of 50 DEG C, adding dECM to the
carbonate buffer to obtain a dECM solution at a concentration of 4% (w / v), sterilizing the solution by
irradiation with radiant
ultraviolet rays for 15 minutes, adding
methacrylic anhydride in an amount of 0.5 mL / 1 g of dECM and reacting at 50 DEG C for 1 hour, and then removing the dECM from the reaction vessel. Then adding a
phosphate buffer
salt solution to obtain a
diluent which is 5 times of the mixture, putting the obtained solution into a
dialysis tube, then putting the
dialysis tube into deionized water, carrying out the stage at 40 DEG C for not more than 4 days, after the stage is completed, transferring the solution in the
dialysis tube into an aluminum plate, and then standing at-80 DEG C for at least 3 hours, and then freeze-
drying the frozen solution under the following conditions: the shelf temperature is 10 DEG C, the pressure is 0.1 mba, and the freeze-
drying time is 48 hours. The invention also relates to the methacrylated dECM obtained by the above process, and to the use of the methacrylated dECM obtained by the above process in a bioprinting process.