The invention discloses a method for suppressing the interference of a neutral line of a prestack seismic signal based on curvelet transform. The method comprises the following steps of: firstly, performing sparse representation on the seismic signal through curvelet transform; secondly, analyzing all coefficient matrixes to obtain frequency layers and directional ranges in which linear interference and effective signals are respectively located, wherein three cases are disposed as follows: 1, for the frequency layers and the direction in which only the linear interference is located, the corresponding curvelet coefficient is set to be 0; 2, for the frequency layers and the direction in which the effective signals and linear interference coexist, the threshold of the curvelet coefficient is suppressed; and 3, for the frequency layers and the direction in which the linear interference is not located, the coefficient keeps unchanged; and finally, performing curvelet transform to obtain a suppressed prestack seismic signal. By the method, the linear interference can be effectively suppressed, and the damage to the effective signals can be reduced to the greatest extent. Moreover, the method has the advantages of simplicity and rapidness.