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2results about How to "High mechanical stiffness" patented technology

High-precision standard plate thickness fixed-point measurement and compensation system and method

The invention provides a high-precision standard plate thickness fixed-point measurement and compensation system and method. The system comprises a base; the two-dimensional object carrying movement module is mounted on the base; the concentric-square-shaped support is fixed to the base and spans the two-dimensional object carrying movement module; the net-shaped precise object carrying platform is arranged on the two-dimensional object carrying motion module and is used for carrying a to-be-measured workpiece and accurately positioning the position of a measuring point; the first laser sensor and the second laser sensor are arranged on the upper side and the lower side of the concentric-square-shaped support; and the control system is in communication connection with the two-dimensional loading motion module, the first laser sensor and the second laser sensor, and is used for controlling the two-dimensional loading motion module to move, accurately positioning the position of the measuring point and calculating the thickness of the workpiece to be measured. A high-precision standard plate thickness fixed-point measurement and compensation system is formed through the high-precision laser sensor, the net-shaped precise object carrying platform and the control system, and the contour of a workpiece to be measured can be described.
Owner:SHANGHAI JIAOTONG UNIV

Use of iron porphyrin compounds in preparation of drugs for inhibiting tumor metastasis

PendingCN122208611ABreak down metabolic flexibilitycontrol deformationOrganic active ingredientsAntineoplastic agents
The application relates to application of an iron porphyrin compound in preparation of a tumor metastasis inhibiting drug and belongs to the technical field of biological medicines. The iron porphyrin compound of the application inhibits tumor metastasis through a triple synergistic mechanism: first, the non-enzymatic catalysis mode is used to improve the intracellular NAD + level, the tumor cell metabolism is changed from glycolysis to oxidative phosphorylation, and the tumor cell metabolic flexibility is broken; second, keratin and intermediate filament protein overexpression is induced, the cell skeleton mechanical rigidity is enhanced, and the tumor cell deformation and migration are limited; and third, CD8 + T cells and M1 type macrophages are activated, the tissue immune surveillance is strengthened, the whole-chain metastasis process of tumor dissociation, intravasation, circulation survival, extravasation and colonization is blocked from the source, and the tumor metastasis key link is comprehensively inhibited.
Owner:SUZHOU UNIV