The invention discloses a high-speed rail bridge support seismic isolation system. The structure of the system comprises a pressure sensor, a seismic isolating rubber support, inner connecting bolts,a silica gel sealing plate, a rubber protection layer sleeve, outer connecting bolts, a steady steel plate layer, a seismic isolating lead core, a seismic reducing rubber layer, a connecting steel plate, a pre-embedded steel plate, a bridge sleeve, and bridge pre-embedded ribs. The pressure sensor is provided with a pressure sensing cap, a sensing cap nested groove, a sensor threaded stud, a sensing data wire, a tail cap nested groove, and a sensor tail cap. The high-speed rail bridge support seismic isolation system realizes high leakproofness and smooth and efficient cooperation and connection of each component, transmits real-time test data of load of pressure and capacity of a bridge, and stores the data and provides to-be-improved load and load values for personnel who performs maintenance and protection at fixed time, so the personnel can change high-strength load materials to improve seismic isolation effect.