The invention relates to a joint bar through type prefabricated circular hole plate wall seismic isolation structure. The structure is of a multi-layer assembly type structure and sequentially comprises a structural bottom plate, a vibration isolation layer floor slab and a plurality of standard layer floor slabs from bottom to top, wherein prefabricated circular hole plate walls serve as wall faces between the floor slabs, every two adjacent prefabricated circular hole plate walls are horizontally connected through a soft cable structure, slurry is poured between the two adjacent prefabricated circular hole plate walls, the upper prefabricated circular hole plate wall and the lower prefabricated circular hole plate wall are vertically connected through a through joint bar, slurry is poured between the upper prefabricated circular hole plate wall and the lower prefabricated circular hole plate wall, the upper portion of the joint bar is fixed through a positioning mold, the top of the first-layer wall is connected with a seismic isolation layer floor through thick steel plates and seismic isolation supports, and the thick steel plates are fixed in a closed mode, so that the integrity of the first-layer wall top horizontal components is enhanced. The novel structure system is light in weight, suitable for standardized production, convenient to transport, convenient and fast to assemble, good in shock insulation performance, firm in overall structure, low in cost, fast to construct and safe in structure.