The invention provides an anti-acne drug and a preparation method thereof. The anti-acne drug is characterized by being prepared from the following medicines: 160g of dandelion, 240g of salvia miltiorrhiza, 240g of scutellaria baicalensis, 48g of coptis chinensis, 150g of eclipta alba, 48g of rheum officinale, 160g of glossy privet fruit, 160g of radix angelicae, 240g of coix lachrymal, 160g of radices trichosanthis, 48g of liquorice, 320g of oldenlandia diffusa, 240g of spina gleditsiae, 48g of radix bupleuri, 120g of cotex dictamni, and 120g of the root bark of white mulberry. The drug is mainly used for clearing heat-toxin and eliminating dampness, activating blood circulation, eliminating carbuncle and expelling pus, can comprehensively condition each viscera and clearly distinguish deficiency and excess, and has the effects of clearing heat to eliminate acne, removing dampness to eliminate acne, expelling carbuncle to eliminate acne, and activating blood circulation to eliminate acne.