The invention provides an APF automatic debugging control method and device, computer equipment and a computer readable storage medium, and relates to the technical field of air conditioners. The APF automatic debugging control method comprises the steps that S1, debugging of the maximum refrigeration mode is carried out, and the minimum valve step is determined; S2, the minimum valve step is kept, debugging of the first intermediate refrigeration mode is carried out, and the minimum frequency of the low-temperature intermediate refrigeration mode is determined; S3, debugging of the low-temperature intermediate refrigeration mode is carried out, and the low-temperature intermediate refrigeration valve step enabling the APF to be maximized is determined; and S4, debugging of the rated refrigeration mode is carried out, and the optimal valve step considering the low-temperature intermediate refrigeration mode and the rated refrigeration mode is determined. The method can be suitable for the new national standard and can also be suitable for an air conditioner with the determined throttling specification, debugging logics of various operation modes are mutually connected and automatically completed, manual participation is not needed, the debugging efficiency is high, and the APF can be improved to the maximum degree.