The invention relates to a printing machine, in particular to a device for displacing printing pressing force and eliminating a tolerance clearance of a curved-surface printing machine. The device for displacing the printing pressing force and eliminating the tolerance clearance of the curved-surface printing machine comprises a printing device which is arranged on a base and is provided with a multi-work-position stepping indexing turntable and a mould handle, and a printing main machine which is arranged on a main machine supporting frame and provided with a transferring printing large drum, and is characterized in that a two-dimensional orthogonal sliding seat is arranged on the base, the main machine supporting frame is arranged on the two-dimensional orthogonal sliding seat through a main machine seat plate, the base is further provided with a longitudinal moving device used for eliminating the clearance, and a programmable logic controller (PLC) which is used for controlling the longitudinal moving device used for eliminating the clearance and is provided with a touch screen, and the longitudinal moving device used for eliminating the clearance is arranged between the base and the main machine seat plate, controls the main machine seat plate to move in the direction perpendicular to the axis of the mould handle, and eliminates the tolerance clearance. The device for displacing the printing pressing force and eliminating the tolerance clearance of the curved-surface printing machine is convenient to operate, is small in vibration, and meets the accuracy requirement for high-speed operation at the speed of 450-650 cups per minute in the cup printing process, and the speed of cup printing is improved by one time compared with existing equipment.