The invention discloses an absorbable
hernia patch with
biological activity and a preparation method, the absorbable
hernia patch comprises a patch, the thickness of the patch is 1mm, a coaxial electrostatic
spinning technology is adopted to prepare fibers with a core-shell structure, the fibers are prepared by compounding poly (p-dioxanone) and poly (L-
lactic acid), the core-shell structure comprises an outer layer material and an inner layer material, and the inner layer material is a porous material.
Naringenin is loaded in the patch; controllable degradation and mechanical support are achieved, poly (p-dioxanone) and poly (L-
lactic acid) are adopted as substrate materials, shell-core structure fibers are formed through coaxial electrostatic
spinning,
tissue repair is promoted through
drug functionalization design,
naringenin with
biological activity is loaded in the patch, the effects of resisting
inflammation and promoting
angiogenesis and collagen deposition are achieved, and the anti-inflammatory effect is achieved. The patch is complete in
fiber morphology, the tensile strength and the elongation at break both reach the level required by
abdominal wall repair, the high quality residual rate is kept in the
degradation process, and the
naringenin can achieve slow release and continuously play a role.