7 results about "Bephenium Compounds" patented technology

The present invention addresses the problem of developing a rare-earth element separating agent having higher durability. The present invention provides: a compound in which diglycol amide acid is introduced into a supporting polymer via an alkyl-substituted benzene compound; and a rare-earth element separating agent and a rare-earth element recovering method which use said compound.

This invention relates to the field of nanomaterials, and discloses a composite nanoparticle, its preparation method, and its application. The preparation method includes: mixing noble metal nanoparticles with an organic synthetic oil and then heating the mixture to react; wherein the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. The composite nanoparticle includes a core and a shell covering the core; the core is a noble metal nanoparticle, and the shell is carbon quantum dots; wherein the carbon quantum dots are carbonized products of the organic synthetic oil; and the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. This composite nanomaterial exhibits excellent stability and light absorption properties.

The invention provides an ON-DNA 3, 4-substituted 3, 4-dihydroquinoxaline-2 (1H)-ketone compound and a preparation method thereof, and relates to the technical field of coding compound libraries. According to the invention, by controlling the conditions of solvent, temperature, pH and the like during reaction, the ON-DNA halogenated nitrobenzene compound can be used for preparing the ON-DNA 3, 4-substituted 3, 4-dihydroquinoxaline-2 (1H)-ketone compound through a two-step method. The method can be carried out in a mixed aqueous phase of an organic solvent / aqueous phase, has the advantages of single product, simple operation and environmental friendliness, and is suitable for synthesis of a DNA coding compound library by using a porous plate.

Antibiotic resistance leads to deadly hospital-acquired infections globally. The World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) have identified priority bacteria, including Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii, and particularly those carbapenem- resistant strains, also found in Enterobacterales (CRE) such as Escherichia coli and Klebsiella, as requiring new antibiotics. The present disclosure provides a chemical class of drugs less susceptible to existing mechanisms of antibiotic resistance and targeting difficult-to-treat bacterial infections. It more particularly provides compounds of formula (I), and compositions and uses thereof.

The application provides a production device, a production device control method and a preparation method of a phenyl chlorosilane. The production device comprises a reactor, a catalyst circulation device and a catalyst. The reactor is used for accommodating a reaction raw material and is provided with an outlet and an inlet. The catalyst circulation device is in communication with the outlet and the inlet respectively and is used for driving at least part of the catalyst to circulate in and out of the reactor. The reaction raw material comprises a chlorosilane and a benzene compound, and the catalyst comprises boron trifluoride or boron trichloride. The application can realize the recycling of the catalyst in the production process of the phenyl chlorosilane, separate the catalyst from hydrogen generated in the reaction, improve the reaction efficiency of the catalyst, and thus reduce the production cost of the phenyl chlorosilane.

The application belongs to the technical field of homogeneous catalysis, and provides application of a ten-core 3d-4f supramolecular nanocage material in catalyzing a three-component aza-Darzens reaction. The application comprises the following steps: mixing an aldehyde compound, an amino benzene compound, ethyl diazoacetate, the ten-core 3d-4f supramolecular nanocage material and an organic solvent, and then performing a reaction to obtain a reaction product, namely completing the three-component aza-Darzens reaction. The ten-core 3d-4f supramolecular nanocage material is used as a catalyst to catalyze the three-component aza-Darzens reaction to realize synthesis of a drug precursor with biological activity, and the catalyst has high catalytic efficiency, the operation steps are simple, and the yield of the target product is also high.

Disclosed in the present invention are a biphenyl compound, a method of preparation thereof, and an intermediate, a pharmaceutical composition and its uses. Specifically provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof. Said compound has good activity and selectivity at a γ retinoic acid receptor agonist, has virtually no agonistic activity at α and / or β retinoic acid receptors, and is thus beneficial for reducing systemic side effects.Preferably, the compound has a rather partial agonistic activity, has low skin irritation and few adverse reactions while maintaining its efficacy, and thus has good safety and compliance, such that the problems commonly present in existing RAR compounds are effectively resolved, and the compound can be used to treat and prevent diseases related to retinoic acid receptor γ.