76 results about "Bephenium Compounds" patented technology

The invention relates to a non-aqueous electrolyte and a lithium secondary battery. In order to solve the problems of poor cycle performance, high impedance and serious gas production of a lithium secondary battery, the invention provides a non-aqueous electrolyte, the non-aqueous electrolyte comprises an organic solvent, a lithium salt and additives, the additives comprise a first additive, a second additive and a third additive, the first additive is selected from one or more of compounds shown in a formula I, and the third additive is selected from one or more of compounds shown in a formula II; the formula I is # imgabs0; the second additive is selected from a compound shown in a formula II and / or a formula III; the formula II is # imgabs 1 #, the formula III is # imgabs 2 #, and the third additive is selected from one or more of double-bond-containing cyclic carbonate, halogen-containing cyclic carbonate, sulfonate, sulfate, sulfite, anhydride, a benzene compound, a fluorobenzene compound, a nitrile compound, phosphate, phosphite, a boron compound, an amine compound, a silicon-containing compound and a heterocyclic compound. Through the synergistic effect of the three additives, the cycle performance of the battery is improved, the impedance of the battery is reduced, and the gas production of the battery is reduced.

A method for preparing a 4,4'-dihydroxybiphenyl compound relates to a method for preparing an organic compound. The method uses 2,6-di-tert-butylphenol as a raw material and a new copper complex as a catalyst to efficiently generate 3,3',5,5'-tetra-tert-butylbiphenyl, which is de-tert-butylated to generate 4,4'-dihydroxybiphenyl. 4,4'-dihydroxybiphenyl is an important organic intermediate, often used as a rubber antioxidant and plastic antioxidant, for colorless vulcanized rubber products, rubber products for food packaging and medical latex products, and also for sulfur chloride cold vulcanized products, such as medical gloves. At the same time, it is also a dye intermediate and a stabilizer for petroleum products, such as a stabilizer for synthetic photosensitive materials and lubricating greases. In terms of synthetic polymers, due to its excellent heat resistance, it is often used as a modified monomer for polyesters, polyurethanes, polycarbonates, polysulfones and epoxy resins, etc., to manufacture excellent engineering plastics and composite materials.

The invention relates to a non-aqueous electrolyte and a lithium secondary battery. In order to solve the problem that a lithium secondary battery cannot give consideration to high and low temperature circulation and rate capability, a first additive, a second additive and a third additive are added into an electrolyte, the first additive is # imgabs0; the second additive is selected from one or more of a fluoro boric acid ester compound, a fluoro carboxylic acid ester compound, a fluoro chain carbonate ester compound, a fluoro phosphate ester compound, a fluoro phosphite ester compound and a fluoro chain sulfonate ester compound; the third additive is selected from one or more of double-bond-containing cyclic carbonate, halogen-containing cyclic carbonate, cyclic sulfonate, sulfate, sulfite, anhydride, a benzene compound, a nitrile compound, halogen-free phosphate, halogen-free phosphite, a halogen-free boron compound, an amine compound, a silicon-containing compound and a six-membered heterocyclic compound; through the synergistic effect of the three additives, the cycle performance and the rate performance of the lithium secondary battery at high and low temperatures are improved.

The present invention addresses the problem of providing a compound having an NLRP3 inflammasome activation inhibitory activity and being useful for the prevention and / or treatment of autoinflammatory diseases, autoimmune diseases and / or inflammatory diseases, or a pharmaceutically acceptable salt thereof. The solution of the present invention is a compound represented by general formula (1) or a pharmaceutically acceptable salt thereof, # imgabs0 # [wherein the symbols are as defined below. In the formula, A represents a carbon atom or the like, R1 represents a halogen atom or the like, R1'represents a hydrogen atom or the like, R1 ''represents a hydrogen atom or the like, R1' 'represents a hydrogen atom or the like, R2 represents a hydrogen atom or the like, R2'represents a hydrogen atom or the like, and R3 represents a C1-C3 alkyl group or the like.

The invention discloses a liquid crystal molecular compound as well as a preparation method and application thereof. The novel naphthalimide-azobenzene compound synthesized by the preparation method disclosed by the invention is a liquid crystal molecule, has a relatively wide temperature range, and presents an obvious focal cone texture during heating and cooling, namely, the target compound is a hexagonal columnar phase (Cohex). The liquid crystal compound possibly has potential application value in the aspects of material chemistry, biotechnology, medicinal chemistry and the like.

The invention provides an N-substituted benzene ring bioisostere and a preparation method thereof, and the N-substituted benzene ring bioisostere is generated by reacting a benzene-containing compound with alkyl carboxylic acid under photocatalysis and electrochemical conditions in the presence of an organic solvent, alkali, electrolyte and a catalyst. The synthesis method provided by the invention is simple to operate and high in atom economy, and the obtained target compound has the characteristics of good functional group compatibility and wide substrate. And the N-substituted benzene ring bioisostere prepared on the basis of the method can be applied to development and modification of pilot drugs, and has good application potential in pharmaceutical chemistry.

The present in vention is directed to methods of treating a metabolic disorder in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a nitro-vinyl benzene compound and administering to the subject a therapeutically effective amount of a GLP-1 agonist or analog. The present invention is also directed to kits and / or pharmaceutical compositions suitable for practicing the claimed methods.

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

The invention relates to the technical field of medicines, in particular to a biphenyl compound and application thereof in resisting clinical drug-resistant bacteria. The biphenyl compound provided by the invention has a structure as shown in a formula I: # imgabs0 #, in the formula I, R1 is H, R2 is C (CH3) 3, and R3 is H; or R1 = C (CH3) 3, R2 = H, and R3 = C (CH3) 3. The biphenyl compound provided by the invention can effectively inhibit various clinical drug-resistant bacteria, and has great application potential.

The application belongs to the technical field of aniline compound preparation, and particularly relates to a synthesis method of deuterated aniline based on transition metal catalyzed nitrobenzene compound. The method uses nitrobenzene compound as raw material, is catalyzed by a low-load transition metal catalyst, and adopts one-pot method to complete the series reaction of high-selectivity hydrogenation and hydrogen-deuterium exchange of the nitrobenzene compound, so that the deuterated aniline compound with high added value is obtained. The yield of the deuterated product and the deuterium substitution rate of the product are better than those of conventional hydrogenation and deuterium substitution, the product is stable and cannot be easily replaced by hydrogen to return to the raw material, and the operation and application are convenient.

The present invention relates to the field of organic synthesis, and particularly relates to a new method for synthesizing 2-chloro-6-nitrotoluene. The synthesis method of 2-chloro-6-nitrotoluene provided by the present invention uses 2,3-dichloronitrobenzene (Compound 1) as a raw material, reacts with methyl cyanoacetate or dimethyl malonate under the action of a reaction solvent and an acid-binding agent to form Compound 2, and after filtration and decolorization, a dilute acid solution is added for de-esterification reaction to obtain Compound 3. Finally, the R group is removed in a dilute acid solution to obtain the final product 2-chloro-6-nitrotoluene (Compound 4). The synthesis method of 2-chloro-6-nitrotoluene described in the present invention has the advantages of simple operation, safety, economy, environmental friendliness, and low cost.

The present invention addresses the problem of developing a rare-earth element separating agent having higher durability. The present invention provides: a compound in which diglycol amide acid is introduced into a supporting polymer via an alkyl-substituted benzene compound; and a rare-earth element separating agent and a rare-earth element recovering method which use said compound.

The invention relates to the field of drug synthesis, in particular to an amine compound for fungi drugs and a preparation method of the amine compound. Comprising the following steps: 1) adding N-bromosuccinimide (NBS) into 4-iodobenzene serving as an initial raw material in an acetonitrile solvent in the presence of benzoyl peroxide serving as a catalyst, and reacting to obtain a 1-bromomethyl-4-iodobenzene compound II; 2) adding N-methylacetamide into the compound II in a tetrahydrofuran solvent by using potassium carbonate as alkali, and reacting to obtain an N-(4-iodobenzyl)-N-methylacetamide compound III; and 3) heating the compound III in a sodium hydroxide solution for deacetylation to obtain the compound IN-methyl-1-(4-iodophenyl) methylamine. The invention aims to provide a preparation process of the N-methyl-1-(4-iodophenyl) methylamine compound I, which is simple, convenient, green, environment-friendly and suitable for industrial production.

The present invention discloses a method for synthesizing an asymmetric azoxybenzene compound. Under light irradiation conditions, iminoiodobenzene and a nitroso compound are reacted in dichloromethane. First, iminoiodobenzene generates nitrene under light irradiation conditions, and then it is captured by the nitroso compound to generate an asymmetric azoxybenzene compound. This method is driven by visible light as a green energy source, without the addition of a catalyst, and the target product can be obtained by reacting for 2 h at room temperature. The reaction conditions are mild and rapid, and at the same time, it is insensitive to air and water and is easy to operate.

A novel disulfide biphenol ether compound and its preparation method and application for treating inflammatory skin diseases, the structural formula of the disulfide biphenol ether compound is: biphenyl diester is first dissolved in anhydrous tetrahydrofuran solvent, lithium aluminum hydroxide is added, quenched, filtered, extracted with dichloromethane, water is added to quench the reaction, extracted with dichloromethane, the organic phases are combined, after removing residual moisture, the reduced pressure rotary evaporation and recrystallization are removed to obtain intermediate 2; intermediate 2 and potassium thioacetate are added to solvent N, N-dimethylformamide and extracted, the organic phases are combined, and the solvent is evaporated and concentrated to obtain a light intermediate 3; intermediate 3 is dissolved in anhydrous methanol, sodium methoxide is added, stirred, extracted with ethyl acetate, and the organic phases are combined to obtain. The disulfide biphenyl compound prepared by the present invention has good anti-inflammatory ability, can effectively reduce inflammatory infiltration in tissue, improve the inflammatory phenotype of animal models, and can prevent and treat inflammatory skin diseases.

The present in vention is directed to methods of treating a metabolic disorder in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a nitro-vinyl benzene compound and administering to the subject a therapeutically effective amount of a GLP-1 agonist or analog. The present invention is also directed to kits and / or pharmaceutical compositions suitable for practicing the claimed methods.

The invention relates to a diaryl thioether photoinitiator as well as a preparation method and application thereof, an aryl thioether photocompound is prepared by reacting substituted benzene with sulfur chloride, and the preparation method specifically comprises the following steps: reacting a substituted benzene compound with S2Cl2 to synthesize an intermediate diaryl thioether compound; the preparation method comprises the following steps: reacting diaryl sulfide with parachlorobenzophenone or parachlorophenyl aminoketone, and synthesizing to obtain an aryl sulfide benzophenone compound or an aryl sulfide alpha-aminoketone compound; according to the synthesis method, thiophenol with stink is not used, and the preparation process is green and environment-friendly and is easy to industrialize; the synthesized compound can be used as a photoinitiator and shows a better photocuring effect.

The invention belongs to the technical field of preparation of organic compounds, and particularly relates to a method for preparing diphenyl hydrazine or 2H-indazole compounds by using an azobenzene compound. The method comprises the following steps: mixing an azobenzene compound, bi-boric acid ester, water and an organic solvent, and reacting to prepare the 2H-indazole compound, the reaction is carried out under visible light; the reaction time is less than 2 hours; the azobenzene compound is selected from any one of the following components: # imgabs0 #, the azobenzene compound is used as a raw material, water is used as a hydrogen source, the bis (borate) is added, the reaction is carried out under visible light irradiation in the absence of a metal catalyst, and the 2H-indazole compound product with the yield not lower than 70% can be prepared after the reaction time is shorter than 1 hour. Moreover, the method disclosed by the invention shows wide functional group compatibility, so that various types of azobenzene compounds can be converted into 2H-indazole compounds.

The objective is to provide a new bisphenol compound with a further improved refractive index. A 1,3-bis(1-methyl-1-phenylethyl)benzene compound of general formula (1) is provided as a solution.

The present invention provides a new method for producing a 3-hydroxybiphenyl compound and a new method for producing a derivative of a 3-hydroxybiphenyl compound using the same. Specifically, the present invention provides a method for producing a compound represented by formula (3), the method comprising a step for obtaining the compound represented by formula (3) by reacting, in a solvent and under the presence of a base, a compound represented by formula (1) [in the formula, R1 and R2 may be the same or different from each other and each represent a C1-C6 chain hydrocarbon group, or may form -(CH2)a- or -(CH2)2-O-(CH2)2- through binding between R1 and R2, and a represents 4 or 5] or a salt thereof with a compound represented by formula (2) [in the formula, R3 represents a C1-C6 chain hydrocarbon group, a chlorine atom, or a hydrogen atom, and X1 represents a chlorine atom, a bromine atom, or an iodine atom].

Disclosed in the present invention are a biphenyl compound, a preparation method therefor, and an intermediate, a pharmaceutical composition and the use thereof. Specifically provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof. The compound has good activity and selectivity on a retinoic acid receptor γ agonist, almost has no agonistic activity on retinoic acid receptors <com:Math><semantics>α<annotation encoding="application / x-tex">\alpha< / annotation>< / semantics>< / com:Math> and / or <com:Math><semantics>β<annotation encoding="application / x-tex">\beta< / annotation>< / semantics>< / com:Math>, and is thus beneficial to reducing systemic side effects. Preferably, the compound has moderately partial agonistic activity, has low skin irritation and few adverse reactions while maintaining its efficacy, and thus has good safety and compliance, such that the problems generally present in existing RAR compounds are effectively solved, and the compound can be used for treating and preventing diseases related to retinoic acid receptor y.

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

This invention relates to the field of nanomaterials, and discloses a composite nanoparticle, its preparation method, and its application. The preparation method includes: mixing noble metal nanoparticles with an organic synthetic oil and then heating the mixture to react; wherein the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. The composite nanoparticle includes a core and a shell covering the core; the core is a noble metal nanoparticle, and the shell is carbon quantum dots; wherein the carbon quantum dots are carbonized products of the organic synthetic oil; and the organic synthetic oil contains at least one selected from biphenyl compounds, hydrogenated products of biphenyl compounds, biphenyl ether compounds, and alkyl aromatic hydrocarbons. This composite nanomaterial exhibits excellent stability and light absorption properties.

The invention provides an ON-DNA 3, 4-substituted 3, 4-dihydroquinoxaline-2 (1H)-ketone compound and a preparation method thereof, and relates to the technical field of coding compound libraries. According to the invention, by controlling the conditions of solvent, temperature, pH and the like during reaction, the ON-DNA halogenated nitrobenzene compound can be used for preparing the ON-DNA 3, 4-substituted 3, 4-dihydroquinoxaline-2 (1H)-ketone compound through a two-step method. The method can be carried out in a mixed aqueous phase of an organic solvent / aqueous phase, has the advantages of single product, simple operation and environmental friendliness, and is suitable for synthesis of a DNA coding compound library by using a porous plate.

The present invention provides: a novel method for producing a 3-phenylcyclohexenone compound having a substituent at the 6-position; and a novel method for producing, by using the same, a derivative of a 3-phenylcyclohexenone compound having a substituent at the 4-position. Provided is a method for producing a compound represented by formula (3), the method comprising a step for mixing a compound represented by formula (1) [in the formula, R1, R2, R3, R4, and R5 are the same as or different from each other, and each represent a hydrogen atom or the like, R6 represents a C1-C6 chain hydrocarbon group which may be substituted with one phenyl group, R7 represents a hydrogen atom or the like, or R6 and R7 may be taken together to form –(CH2)4- or the like] or a salt thereof, a compound represented by formula (2) [in the formula, R8 represents a C1-C12 chain hydrocarbon group, and R9 represents a hydrogen atom or the like], and an alkali metal carbonate, and reacting these components in the presence of pyrrolidone to obtain a compound represented by formula (3) [in the formula, R1, R2, R3, R4, R5, R8, and R9 have the same meanings as above].

The invention relates to a novel disulfide diphenol ether compound and a preparation method and application thereof in the aspect of treating inflammatory dermatosis, the structural formula of the disulfide diphenol ether compound is # imgabs0, bifendate is dissolved in a solvent anhydrous tetrahydrofuran, lithium aluminum hydride is added, quenching, suction filtration, dichloromethane extraction, water addition quenching reaction and dichloromethane extraction are carried out, and the disulfide diphenol ether compound is obtained. Combining organic phases, removing residual moisture, and performing reduced pressure rotary evaporation recrystallization to obtain an intermediate 2; adding the intermediate 2 and potassium thioacetate into a solvent N, N-dimethylformamide for extraction, combining organic phases, and carrying out evaporation and concentration to remove the solvent so as to obtain a light intermediate 3; and dissolving the intermediate 3 with absolute methanol, adding sodium methoxide, stirring, extracting with ethyl acetate, and combining organic phases. The disulfide biphenyl compound prepared in the invention has good anti-inflammatory ability, can effectively reduce inflammation infiltration in tissues, improves the inflammation phenotype of an animal model, and can prevent and treat inflammatory skin diseases.

The present invention provides a novel EZH2 inhibitor compound represented by formula (I) and a use of the inhibitor compound in preventing or treating a disease mediated by EZH2.

The invention relates to the field of resin, in particular to a preparation method and application of modified polyolefin water-based resin, and the preparation method comprises the following steps: (1) mixing maleic anhydride modified polyolefin resin with a first cosolvent to obtain a phase 1; (2) mixing the mixed monomer with a first initiator to obtain a phase 2; (3) mixing the phase 1, the phase 2 and a second initiator to obtain a semi-finished product; and (4) adding a neutralizer, an emulsifier and a second cosolvent into the semi-finished product, mixing, adding hot water, and carrying out phase inversion emulsification. The maleic anhydride modified polyolefin modified fluorine-containing acrylic acid water-based resin obtained by the invention has good water solubility, is free of benzene compounds and other heavy metal substances in formula components, is non-toxic to human health, has excellent weather resistance, wear resistance, stain resistance, scrubbing resistance, adhesive force and the like after being cured, and can be widely applied to the field of water-based paint. The method is especially suitable for the fields of automotive interiors and the like in direct contact with human bodies.