The present invention provides a medicament comprising a
benzene compound useful as an
insulin sensitizer, a salt thereof or a
hydrate of them and a derivative of them as the
active ingredient. Specifically, it provides a
benzene compound represented by the following formula, a salt thereof or a
hydrate of them. In the formula, X represents 1) a C6-10
aryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: (in the above formulae, R<y1>, R<y2 >and R<y3 >are the same as or different from one another and each represents a
hydrogen atom, a
halogen atom, a C1-6
alkyl group, a C1-6
alkoxy group, or a C3-7 cycloalkyl group) etc.; Z represents a group represented by the formula: (in the formula, m represents an integer of 0 to 2; R<z1, R><z2>, R<z3 >and R<z4 >are the same as or different from one another and each represents a
hydrogen atom, a
halogen atom, a C1-6
alkyl group, a C1-6
alkoxy group, a C3-7 cycloalkyl group, a halogenated C1-6
alkyl group, a halogenated C1-6
alkoxy group etc.); and R<1>, R<2>, R<3 >and R<4 >are the same as or different from one another and each represents a
hydrogen atom, a
halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-7 cycloalkyl group etc.