The invention relates to the technical field of individualized
cognition, in particular to an individualized
cognitive decline risk prediction method and
system based on multi-mode data fusion. According to the method, multi-
modal longitudinal evidence-based data is integrated on the basis of a group-level
pathology law, a multi-scale
causal link map capable of reflecting the complete period of
cognitive decline is formed,
pathology time axis alignment and individualized feature normalization are achieved, the dynamic
pathology process of individual specificity can be captured, and the accuracy of the pathology process is improved. By fitting individual exclusive multi-scale causal parameters and constructing a
time sequence cascade digital twinborn body, forward causal
simulation can be executed on multiple time scales, a
cognitive decline core driving path is directly revealed, and
individual risk quantification and intervention targets are generated. Detection of early hidden
pathological signals, dynamic modeling of individual heterogeneity and comprehensive analysis of a multi-channel
pathological mechanism are achieved, the ultra-
early prediction precision of cognitive decline and individualized intervention suitability are remarkably improved, and a full-period
prediction system capable of being iteratively optimized continuously is formed.