9 results about "Hyaluronan synthesis" patented technology

The invention relates to hyaluronic acid-based nanogel with intestinal targeting and inflammation responsiveness as well as a preparation method and application of the hyaluronic acid-based nanogel, and discloses multifunctional composite nanogel based on hyaluronic acid as well as a preparation method and application of the multifunctional composite nanogel. The preparation method comprises the following steps: loading galangin into bovine serum albumin to prepare BSA-GA nanoparticles with antioxidant and anti-inflammatory activity; 2, synthesizing a multifunctional molecule Se-MHA which is targeted to M2 macrophages and responds to ROS degradation on the basis of hyaluronic acid; 3, BSA-GA nano-particles with the same solution concentration are used as anti-inflammatory functional components to be mixed with Se-MHA to prepare Se-MHA / BG nano-gel, model probiotics are subjected to single-cell modification, probiotic-loaded nano-gel EcN-Se-MHA / BG is prepared, the nano-gel has specific binding and responding capacity on the colitis disease part, colonization of EcN on the colon part is promoted, and the anti-inflammatory effect is achieved. The IBD disease is effectively relieved.

The invention belongs to the technical field of nutritional compositions and cosmetics, and particularly relates to an anti-aging composition and application and a product thereof. The composition provided by the invention is composed of L-ergothioneine and alpha-ketoglutaric acid, or L-ergothioneine and alpha-ketoglutaric acid salt, or L-ergothioneine and alpha-ketoglutaric acid salt. Through the synergistic effect of the L-ergothioneine and the alpha-ketoglutaric acid or the alpha-ketoglutarate, the contents of Col I and hydroxyproline in skin tissues can be remarkably increased, the expression of TGF-beta1 is up-regulated and converted, the activity of MMP-1 is inhibited, meanwhile, the malondialdehyde level is reduced to enhance the oxidation resistance, the synthesis of hyaluronic acid is promoted, and the water content of the skin is increased. The composition is simple in component and simple and convenient in preparation process, can be prepared into various products such as cosmetics, health care products or medicines, is used for achieving the effects of resisting aging, moisturizing, resisting inflammation or resisting oxidation, particularly has an excellent improvement effect on skin photoaging induced by ultraviolet rays, and is wide in application prospect.

This invention provides pharmaceutical compositions for inhibiting inflammation and their applications. The invention reveals that the combined use of hyaluronic acid synthesis inhibitors and ascorbate palmitate or their analogues can synergistically inhibit inflammation, significantly improving the therapeutic effect; the inflammation may include systemic inflammation and SARS-CoV-2 infection-related inflammation, including pneumonia. This invention also reveals a novel coronavirus inflammation model obtained by stimulating cells with specially isolated polynucleotides derived from the novel coronavirus genome. The model exhibits a typical inflammatory phenotype, is stable and controllable, and is intuitive and easy to observe.

The present disclosure relates to a functional cosmetic composition using broccoli exosomes as an active ingredient and a functional cosmetic product containing the same. The broccoli exosomes have a lipid bilayer structure and are well absorbed into skin cells, and the absorbed broccoli exosomes remove reactive oxygen within skin cells and stimulate anti-oxidant signaling mechanisms, so they show anti-oxidant efficacy, and promote hyaluronic acid synthesis, and thus, they can be useful for preparation of functional cosmetics for skin aging prevention, skin whitening, wrinkle improvement and skin cell regeneration.

This invention discloses a method for preparing tree tomato leaf extract, its products, and applications, belonging to the field of natural product extraction and application. The method involves taking tree tomato leaf powder, using a 60% ethanol aqueous solution as the extraction solvent, extracting at a material-to-liquid ratio of 1:30 g / mL and a temperature of 60°C for 45 min, repeating the extraction twice, combining the two filtrates, concentrating, and drying to obtain the tree tomato leaf extract. This extract is highly enriched with polyphenols, flavonoids, and other active ingredients, exhibiting multiple effects such as antioxidant, anti-inflammatory, tyrosinase inhibition, and promotion of hyaluronic acid synthesis. It has also been confirmed that it has no significant cytotoxicity, phototoxicity, or skin sensitization. Cosmetic compositions containing this extract can effectively improve skin hydration, barrier function, redness, and dullness, and are suitable for preparing multifunctional pharmaceuticals or cosmetics with anti-inflammatory, whitening, moisturizing, and anti-aging properties, providing strong support for the high-value utilization and development of tree tomato leaf resources.

The application discloses a preparation method of chitosan-derived carbon dots, the carbon dots and application of the carbon dots. The carbon dots are prepared by covalent coupling of octyl-lactic acid chitosan-based amphiphilic polymer carbon dots and 2,3-epoxypropyl trimethyl ammonium chloride modified wood-based carbon dots through amidation. The octyl hydrophobic chain breaks the hydrogen bond shielding of chitosan, exposes active sites and improves the reactivity; the wood-based carbon dots are modified by quaternary ammonium, the compatibility is improved and the targeting is given. The triple synergistic anti-aging effect of removing active oxygen, up-regulating LaminB1 expression and inhibiting IL-6 / IL-8 secretion can be realized. Cell experiments show that the carbon dots can significantly reduce the UVA-induced oxidative damage, improve the synthesis of hyaluronic acid, reduce the cell aging level, and have no obvious cytotoxicity in the effective concentration. The carbon dots have a good application prospect in the fields of antioxidant, skin photoaging protection, anti-aging cosmetics and medical repair materials.

The invention relates to the technical field of fermentation equipment, in particular to a hyaluronic acid fermentation liquor preparation device and a preparation method thereof.The hyaluronic acid fermentation liquor preparation device comprises an outer cylinder and an inner cylinder which are coaxial, an outer interlayer and an inner interlayer are constructed in the outer cylinder and the inner cylinder respectively, and the outer interlayer and the inner interlayer of the outer cylinder and the inner cylinder communicate with each other to form a fermentation barrel; a fermentation cavity is formed between the outer barrel and the inner barrel, a barrel cover is arranged at the upper end of the fermentation cavity, and a heat circulator located between the outer interlayer and the inner interlayer is arranged on the fermentation barrel; heat of heat conduction liquid is synchronously diffused to the annular fermentation cavity through the inner side wall of the outer barrel and the outer side wall of the inner barrel, an outer barrel heat conduction covering cavity outer side culture medium and an inner barrel heat conduction covering cavity inner side culture medium, so that bidirectional wrapping type heat transfer is formed, and the problems of edge high temperature and center low temperature caused by traditional single-wall heating are solved; the temperature of each area of the culture medium in the annular fermentation cavity is more uniform and stable, and a better temperature environment is provided for strain metabolism and hyaluronic acid synthesis.

This application discloses a method for preparing chitosan-derived carbon dots, the derived carbon dots themselves, and their applications. These carbon dots are prepared by amidation covalent coupling of octyl-citric acid chitosan-based amphiphilic polymer carbon dots and 2,3-epoxypropyltrimethylammonium chloride-modified lignin-based carbon dots. The octyl hydrophobic chain disrupts the hydrogen bond shielding of chitosan, exposing active sites and enhancing reactivity. Quaternization modification of the lignin-based carbon dots improves compatibility and imparts targeting properties. This achieves a triple synergistic anti-aging effect, scavenging reactive oxygen species, upregulating LaminB1 expression, and inhibiting IL-6 / IL-8 secretion. Cell experiments show that these carbon dots significantly reduce UVA-induced oxidative damage, increase hyaluronic acid synthesis, and reduce cellular senescence levels, with no significant cytotoxicity within effective concentrations. They show promising application prospects in the fields of antioxidants, skin photoaging protection, and anti-aging cosmetics and medical repair materials.

This invention belongs to the field of microbial preparation technology, specifically relating to an epigenetic agent and its composition, and their application in synergistically promoting the transdermal permeability of sodium hyaluronate and in its powerful water-locking, hyaluronic acid synthesis-promoting, and skin water-oil balance effects. This invention combines an epigenetic agent obtained through fermentation of specific strains with sodium hyaluronate, which can significantly improve the transdermal delivery efficiency of sodium hyaluronate. Simultaneously, the epigenetic agent in this invention can inhibit the degradation of sodium hyaluronate by hyaluronidase in the skin surface, significantly prolonging the residence time of sodium hyaluronate in various skin layers, resulting in a significant long-lasting water-locking advantage. Furthermore, the epigenetic agent in this invention can also promote the synthesis of endogenous hyaluronic acid in the skin, fundamentally improving the skin's own water-retention capacity. This forms a dual moisturizing mechanism with exogenous sodium hyaluronate supplementation, resulting in a significantly better moisturizing and water-locking effect than using sodium hyaluronate alone. Therefore, it can be used as a cosmetic anti-aging product and has good practical application value.