4 results about "Hyaluronan synthesis" patented technology

This invention provides pharmaceutical compositions for inhibiting inflammation and their applications. The invention reveals that the combined use of hyaluronic acid synthesis inhibitors and ascorbate palmitate or their analogues can synergistically inhibit inflammation, significantly improving the therapeutic effect; the inflammation may include systemic inflammation and SARS-CoV-2 infection-related inflammation, including pneumonia. This invention also reveals a novel coronavirus inflammation model obtained by stimulating cells with specially isolated polynucleotides derived from the novel coronavirus genome. The model exhibits a typical inflammatory phenotype, is stable and controllable, and is intuitive and easy to observe.

This invention discloses a method for preparing tree tomato leaf extract, its products, and applications, belonging to the field of natural product extraction and application. The method involves taking tree tomato leaf powder, using a 60% ethanol aqueous solution as the extraction solvent, extracting at a material-to-liquid ratio of 1:30 g / mL and a temperature of 60°C for 45 min, repeating the extraction twice, combining the two filtrates, concentrating, and drying to obtain the tree tomato leaf extract. This extract is highly enriched with polyphenols, flavonoids, and other active ingredients, exhibiting multiple effects such as antioxidant, anti-inflammatory, tyrosinase inhibition, and promotion of hyaluronic acid synthesis. It has also been confirmed that it has no significant cytotoxicity, phototoxicity, or skin sensitization. Cosmetic compositions containing this extract can effectively improve skin hydration, barrier function, redness, and dullness, and are suitable for preparing multifunctional pharmaceuticals or cosmetics with anti-inflammatory, whitening, moisturizing, and anti-aging properties, providing strong support for the high-value utilization and development of tree tomato leaf resources.

The application discloses a preparation method of chitosan-derived carbon dots, the carbon dots and application of the carbon dots. The carbon dots are prepared by covalent coupling of octyl-lactic acid chitosan-based amphiphilic polymer carbon dots and 2,3-epoxypropyl trimethyl ammonium chloride modified wood-based carbon dots through amidation. The octyl hydrophobic chain breaks the hydrogen bond shielding of chitosan, exposes active sites and improves the reactivity; the wood-based carbon dots are modified by quaternary ammonium, the compatibility is improved and the targeting is given. The triple synergistic anti-aging effect of removing active oxygen, up-regulating LaminB1 expression and inhibiting IL-6 / IL-8 secretion can be realized. Cell experiments show that the carbon dots can significantly reduce the UVA-induced oxidative damage, improve the synthesis of hyaluronic acid, reduce the cell aging level, and have no obvious cytotoxicity in the effective concentration. The carbon dots have a good application prospect in the fields of antioxidant, skin photoaging protection, anti-aging cosmetics and medical repair materials.

This application discloses a method for preparing chitosan-derived carbon dots, the derived carbon dots themselves, and their applications. These carbon dots are prepared by amidation covalent coupling of octyl-citric acid chitosan-based amphiphilic polymer carbon dots and 2,3-epoxypropyltrimethylammonium chloride-modified lignin-based carbon dots. The octyl hydrophobic chain disrupts the hydrogen bond shielding of chitosan, exposing active sites and enhancing reactivity. Quaternization modification of the lignin-based carbon dots improves compatibility and imparts targeting properties. This achieves a triple synergistic anti-aging effect, scavenging reactive oxygen species, upregulating LaminB1 expression, and inhibiting IL-6 / IL-8 secretion. Cell experiments show that these carbon dots significantly reduce UVA-induced oxidative damage, increase hyaluronic acid synthesis, and reduce cellular senescence levels, with no significant cytotoxicity within effective concentrations. They show promising application prospects in the fields of antioxidants, skin photoaging protection, and anti-aging cosmetics and medical repair materials.