The invention discloses a method for multi-gas co-production and production capacity replacement of coal-measure strata, which comprises the following steps: Step 1, selecting a block in which coal seams and tight sandstone layers are relatively developed in coal-measure strata, and drilling a U-shaped block in the block Well, wherein, the horizontal section of the U-shaped well is in an inclined state, and the horizontal section passes through multiple reservoirs at the same time; step 2, the multiple reservoirs that the horizontal well section passes through are used for joint production by fracturing, and the high Gas production in the vertical well section at the structural position, drainage and fines discharge in the vertical well section at the low structural position and gas production; step 3, when the gas production of the horizontal well section decreases, use a packer to isolate the vertical well section from the horizontal section, and use The two vertical sections of the U-shaped well produce gas from the sandstone layer; step 4, when the gas production in step 3 decreases, all the reservoirs are combined for production. The method proposed by the invention solves the problems of coal seam water production and pressure mismatch between high-pressure and low-pressure reservoirs, reduces the interference of coal seam pulverization, and realizes production capacity replacement in coal-measure gas development.