The invention discloses a surge protection circuit and a protection method for an internet of things mobile base station, belonging to the field of internet of things mobile base stations; a surge protection circuit and a protection method for an internet of things mobile base station, comprising: a signal transmitting unit , a signal receiving unit, a data control unit, a data storage unit, and an interface unit; the interface unit includes: a signal isolation module, a signal modulation module, and an amplitude limiting filter module; when the present invention receives user signals through the receiver, the data is transferred through the interface. The control unit, at the same time, when the signal output is transmitted, it is output to the transmitter through the interface unit, which can increase the conversion time and buffering of the signal, so as to better stabilize the signal, so as to be stable in the environment with strong thunderstorm signal interference. During signal transmission, a delay will be added to each transmission set, and the sub-signals in each transmission set will be signal-isolated, so that the signals do not interfere with each other.