The invention discloses a PCB dielectric slice selection method, device and system, and the method comprises the steps: determining a first distance between two pieces of adjacent glass fiber cloth in PCB dielectric slices of various specifications, and then determining a combination of a second distance between two lines of a to-be-set differential line, the impedance of which is preset impedance; subsequently determining the target PCB dielectric sheet from the PCB dielectric sheets satisfying the second distance = N * first distance according to the setting direction of the differential line to be set on the PCB, so that the second distance = N * first distance, the impedance of the PCB dielectric sheets through which the two lines of the differential line pass is the same. Therefore, the two lines generate the same signal delay, the difference Skew influence caused by the glass fiber effect is avoided, the common-mode voltage is inhibited, the system crosstalk and EMI interference are reduced, the signal eye pattern quality is improved, in addition, the cost is low, the utilization rate of the plate is ensured, and the reliability is high.