The invention relates to a single-stage bridgeless boost Cuk resonant LED drive circuit, comprising a bridgeless boost Cuk circuit unit and an LLC circuit unit, wherein a lower switch tube in the LLC circuit unit and a bridgeless boost Cuk circuit unit The switch tubes share a power switch tube, and the bridgeless boost Cuk circuit and the LLC circuit are integrated into a single-stage AC-DC drive circuit by multiplexing the power switch tube. where the input AC power supply V in , power diode D 1 ~D 6 and D 8 , inductance L 1 , L 2 and L 3 , the intermediate capacitor C 1 and C 2 , bus capacitance C bus , the second power switch tube S 2 Constitute a bridgeless boost Cuk circuit unit; power diode D 7 , D9‑D 12 , Power switch tube S 1 , S 2 , resonant inductance L r , resonant capacitor C r , high frequency transformer T with center tap on secondary side, output capacitor C 0 It constitutes an LLC circuit unit. The invention realizes the bridgeless single-stage PFC circuit and the ZVS soft switching through the multiplexing of the bridgeless boosting Cuk PFC circuit and the LLC circuit switch tube, and reduces the conduction loss and switching loss of the main circuit of the converter.