The invention discloses a detachable negative oxygen ion air purification mask. The detachable negative oxygen ion air purification mask comprises a mask body and is characterized by further comprising a substrate, an installing hole, a negative oxygen ion releasing hole, an installing plate, an installing ring, a locking plate, a miniature negative oxygen ion generator, a miniature storage battery, a control panel, a control switch, a USB interface and an installing cover. According to the detachable negative oxygen ion air purification mask, an environment rich in negative oxygen ions is formed in the mask through the negative oxygen ion generator and can effectively kill bacteria and remove dust and smog to protect the respiratory system and health of a user; the miniature storage battery can supply electricity for a long time, limitation to electricity utilization is avoided, the usage range is widened, and convenience is improved; the installing plate can be disassembled through clockwise and anticlockwise rotation, the service life of the mask is greatly prolonged, the use quality is improved, and use cost is saved.