The invention provides a wireless noise reduction earphone, which comprises an earmuff shell, the earmuff shell is provided with an accommodating cavity, a moving coil is fixedly arranged in the accommodating cavity, the accommodating cavity is divided into a front cavity and a rear cavity by the moving coil, the earmuff shell is provided with a sound outlet communicated with the front cavity, a feedback microphone and a high-frequency sound production unit are fixedly arranged in the front cavity, and the high-frequency sound production unit is arranged in the rear cavity. The high-frequency sounding unit is a moving iron, a planar diaphragm or an MEMS loudspeaker; the earmuff is connected with the earmuff shell, the earmuff is provided with a cavity with two open ends, part of the earmuff shell extends into the cavity and is clamped with the earmuff, and the feedback microphone and the high-frequency sounding unit are located in the cavity of the earmuff; and the ear rod is connected with the rear cavity of the ear muff shell, and a feed-forward microphone is arranged in the ear rod. The wireless noise reduction earphone is small in size, comfortable to wear and good in sound quality effect and noise reduction effect.