13 results about "BK virus" patented technology

This invention belongs to the field of biodetection technology, specifically relating to a monoclonal antibody 3C7 for detecting BK virus VP1 protein and its applications. The amino acid sequences of the heavy chain variable regions CDR1, CDR2, and CDR3 of the monoclonal antibody are SEQ ID NO. 1–3, and the amino acid sequences of the light chain variable regions CDR1, CDR2, and CDR3 are SEQ ID NO. 4–6, respectively. This antibody exhibits high specificity and can recognize the BK virus VP1 protein. The test strip includes a backing plate, a sample pad, a colloidal gold pad, a nitrocellulose membrane, and absorbent paper. The detection method provided by this invention is simple to operate, highly sensitive, and requires no instruments, enabling rapid and visual detection of BK virus VP1 in urine or recombinant protein samples. It is suitable for on-site screening and point-of-care testing and can supplement existing detection methods such as nucleic acid testing.

New thiazole and isoquinoline containing compounds for treating and / or preventing a broad spectrum of viral infections are provided. Methods for treating and / or preventing a broad spectrum of viral infections are also provided. These compounds have shown inhibition of HCMV, influenza virus, Zika virus, BK virus and RSV replication in cell-based assays.

Novel thiazole- and isoquinoline-containing compounds are presented that are useful for treating and / or preventing broad-spectrum viral infections. Methods of treating and / or preventing broad-spectrum viral infections are also presented. These compounds have shown inhibition of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

The invention belongs to the technical field of biological detection, and particularly relates to a monoclonal antibody 3C7 for BK virus VP1 protein detection and application. The amino acid sequences of heavy chain variable regions CDR1, CDR2 and CDR3 of the monoclonal antibody are respectively SEQ ID NO.1-3, and the amino acid sequences of light chain variable regions CDR1, CDR2 and CDR3 of the monoclonal antibody are respectively SEQ ID NO.6-6. The antibody has high specificity and can recognize the BK virus VP1 protein. The test strip comprises a back plate, a sample pad, a colloidal gold pad, a nitrocellulose membrane and absorbent paper. The detection method provided by the invention is simple and convenient to operate and high in sensitivity, does not need instruments, realizes rapid and visual detection of the BK virus VP1 in urine or a recombinant protein sample, is suitable for on-site screening and instant detection, and can be used as a supplement of existing detection means such as nucleic acid and the like.

The present patent application relates to the fields of antibodies and polyomaviruses. More specifically, the present patent application relates to a human monoclonal antibody, or antigen- binding fragment thereof, directed against a polyomavirus, in particular BKV, and that is useful in the treatment of an infection by said polyomavirus or associated-disorder thereof.

The invention relates to the technical field of detection, and particularly provides a BK virus and unknown pathogen detection method and system based on microfluidics, and the method comprises the following steps: analyzing a genome of a BK virus and / or unknown pathogen, determining a feature sequence and a variation site, and screening out a target sequence suitable for nucleic acid detection; based on a dry molecular diagnosis technology, drying conditions and a reaction system are optimized, and a dry reagent sample is obtained based on the optimized drying conditions and reaction system; and pre-loading a dry reagent sample into a reaction cavity of the micro-fluidic chip, collecting the sample, and carrying out data analysis and detection. Based on a dry type molecular diagnosis technology, the method has remarkable advantages in the field of molecular detection, the detection efficiency, specificity and sensitivity are improved, and the cost is reduced; on the basis of a micro-fluidic chip technology, huge potential is shown in nucleic acid detection, and especially in the aspects of rapid detection and field detection, the detection efficiency and accuracy can be remarkably improved.

The present patent application relates to the fields of antibodies and polyomaviruses. More specifically, the present patent application relates to a human monoclonal antibody, or antigen-binding fragment thereof, directed against a polyomavirus, in particular BKV, and that is useful in the treatment of an infection by said polyomavirus or associated-disorder thereof.

The present patent application relates to the fields of antibodies and polyomaviruses. More specifically, the present patent application relates to a human monoclonal antibody, or antigen-binding fragment thereof, directed against a polyomavirus, in particular BKV, and that is useful in the treatment of an infection by said polyomavirus or associated-disorder thereof.

The application discloses a kind of graft injury multi-index combined noninvasive detection kit, by optimized multiplex real-time fluorescent quantitative polymerase chain reaction technology, realize the quantitative detection of six categories with closely related DNA virus after transplantation Complications, the present application relates to the field of in vitro detection technology of clinical sample.The graft injury multi-index combined noninvasive detection kit, the present application first realizes the synchronous detection of BK virus, JC virus, B19 virus, CMV virus, adenovirus and six kinds of closely related viruses of circovirus (TTV) with graft injury.Test data see example 7, from the detection results of 100 clinical kidney transplant patients, it can be seen that the kit of the present application can simultaneously accurately detect the load level of six viruses, to provide comprehensive infection risk assessment for clinicians.Compared with the prior art single virus detection method, the present application avoids the cumbersome process of multiple sampling and detection, significantly improves the clinical work efficiency.

Provided herein are compositions comprising isolated T cells specific for one or more viral antigens derived from viruses such as adenovirus (ADV), cytomegalovirus (CMV), BK virus (BKV), Epstein-Barr virus (EBV), human herpes virus 6 (HHV6), John Cunningham virus (JC), or human immunodeficiency virus (HIV), methods for obtaining them, libraries including them, and uses thereof in treating viral infections.

The invention discloses a multiplex fluorescent quantitative PCR (Polymerase Chain Reaction) reagent for synchronously detecting five DNA (Deoxyribose Nucleic Acid) viruses related to infertility. The multiplex fluorescent quantitative PCR reagent comprises specific primers and probes aiming at a simian vacuolar virus 40, a molluscum contagiosum virus, a Merkel cell polyoma virus, a BK virus and a torque teno virus; according to the method, the five viruses can be synchronously detected in a single reaction tube, meanwhile, the load of the viruses can be quantified, the reagent has the advantages of being high in specificity and sensitivity, high in repeatability and reproducibility, easy to operate, short in consumed time and the like, and when large-scale clinical screening application is carried out, the reagent has the advantages of being high in specificity and sensitivity, good in repeatability and reproducibility and the like. The detection efficiency of the five viruses can be greatly improved, the detection cost can be reduced, and the detection result can provide important reference for the formulation of an individualized treatment scheme, so that the application has important value and significance for clinical rapid screening and diagnosis and improvement of the treatment effect.

Novel thiazole- and isoquinoline-containing compounds are presented that are useful for treating and / or preventing broad-spectrum viral infections. Methods of treating and / or preventing broad-specturm viral infections are also presented. These compounds have shown inhibition of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

The present invention relates to broad spectrum antiviral compositions and methods. In particular, the present invention provides novel thiazole and isoquinoline containing compounds for use in the treatment and / or prevention of broad spectrum viral infections. Methods of treating and / or preventing broad spectrum viral infections are also provided. These compounds have shown inhibition of HCMV, influenza virus, Zika virus, BK virus and RSV replication in cell-based assays.