The invention discloses a self-cascade refrigeration system with a double-stage compression function. The self-cascade refrigeration system is characterized in that a compressor (1) is provided with an intermediate air supplement port, refrigerants adopt two non-azeotropic refrigerants, an exhaust port of the compressor is sequentially connected with a condenser (3) and a gas-liquid separator (4),the high-boiling-point refrigerant discharged from the lower part of the gas-liquid separator sequentially flows through a heat regenerator (6), a first throttling component (7), a condensation evaporator (8) to a port A of a three-way valve (9), the low-boiling-point refrigerant discharged from the upper part of the gas-liquid separator sequentially flows through the condensation evaporator (8),a second throttling component (10), an evaporator (2), a rectifying pipe (11) arranged in the gas-liquid separator and the heat regenerator (6) and then is mixed with the refrigerant discharged froma port B of the three-way valve and then is returned to an air suction port of the compressor, and a port C of the three-way valve is connected with the air supplement port of the compressor. According to the system, the structure is simple, the power consumption can be effectively reduced, the refrigerating capacity can be improved, the lower temperature can be prepared, and the efficiency can beimproved.