The invention relates to a reaction device based on constant-temperature regulation and control. The device comprises a base, a stand column, a stirring connecting rod, a motor, a stirring rod, a temperature sensor, a reaction container, a water tank and a constant-temperature circulating tank, wherein the stand column is arranged on the base; one end of the connecting rod is connected with the stand column through a cross clamp. The other end of the connecting rod is connected with a motor; the output end of the motor is connected with one end of the stirring rod, the other end of the stirring rod is arranged in the reaction container, the temperature sensor is arranged in the stirring rod, the reaction container is arranged in the water tank, an outlet of the water tank is communicated with an inlet of the constant-temperature circulating tank through a pipeline, and an inlet of the water tank is communicated with an outlet of the constant-temperature circulating tank through a pipeline. According to the invention, the constant-temperature circulating tank and the water tank are separately arranged, and the constant-temperature circulating tank provides a solution with stable temperature for the water tank, so that the temperature in the reaction container is kept stable, the reaction rate is kept stable, the abnormal probability of a reaction system due to temperature changeis reduced, and the probability of chemical accidents is reduced.