Provided are a multiple thin wall titanium tube and steel tube sheet hole simultaneous explosive welding composite tube sheet and a multiple thin wall titanium tube and steel tube sheet hole simultaneous explosive welding method. The multiple thin wall titanium tube and steel tube sheet hole simultaneous explosive welding method includes following steps: first, filling thin wall titanium tubes with explosives obtained through an optimized formula, wherein the wall thickness of the thin wall titanium tubes is 1-2mm, the optimized formula consists of components by weight part: 60-70 parts of theexplosives and the balance of ingredients composed of salt, perlite and saw powder, and the weight ratio of the salt, the perlite and the saw powder in the ingredients is 2:1:1; exposing unstable detonation ends out of two surfaces of a steel sheet separately by 2-10cm in explosive loading; secondly, controlling the distance between the outer wall of each thin wall titanium tube and the inner wall of each steel tube sheet hole as S=0.2*(delta+h), wherein the h is the thickness of titanium steel obtained after explosive forming, the delta is the diameter of the filling explosives, and the h isfar less than the delta; thirdly, using a series firing network for connecting all detonators, and controlling the length of a firing circuit within 200m. The multiple thin wall titanium tube and steel tube sheet hole simultaneous explosive welding method not only can guarantee safety of a heat exchanger, but also greatly prolongs use life of the heat exchanger, is high in production rate, can achieve welding forming of all tubes and tube sheets of the whole heat exchanger at a time.