6 results about "Peripheral blood flow" patented technology

Perfusion systems and methods are provided for enhancing perfusion to the vasculature of a patient suffering from reduced blood flow. For example, the system can increase peripheral blood flow to reduce limb ischemia, in which an extracorporeal pump having a controller, and catheter / tubing set, employed alone or in conjunction with an interventional or circulatory assist device, withdraws blood from a patient's vasculature and reintroduces that blood at another location within the patient's vasculature at a controlled local pressure or flow rate, without interfering with operation of the interventional or circulatory assist device or surgical intervention.

A flexible layered material comprises an outer skin; a first flexible fabric layer having a thickness of about 6mm to about 10mm; and a second flexible fabric layer having a thickness of about 17mm to about 22mm; wherein, in use, the outer skin is capable of facing a patient; the first fabric layer is positioned between the outer skin and the second fabric layer and comprises a plurality of first densely packed substantially parallel fibrous ribs between a first sheet proximate to the outer skin and a second sheet distant to the outer skin; and the second fabric layer comprises a plurality of second densely packed substantially parallel fibrous ribs between a third sheet proximate to the first fabric layer and a fourth sheet distant to the first fabric layer. The material is for use in an acute or hospital care setting to reduce the occurrence of pressure ulcers caused either by skin shearing or the breaking down of tissue through a lack of peripheral blood flow in patients required to spend time in a reclined or sitting position.

A cell product may be used for treating a peripheral blood flow disorder, and the cell product may include an SSEA-3-positive pluripotent stem cells (Muse cells) derived from a mesenchymal tissue in a living body or a cultured mesenchymal cell. The peripheral blood flow disorder is preferably a peripheral arterial disease, more preferably chronic arterial obstruction in a limb.

Noninvasive methods and apparatus for detecting blood volume imbalances in a mammalian subject are disclosed. The method includes obtaining baseline measurements of at least three physiological parameters from a subject wherein the parameters are selected from the group consisting of heart rate, electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity. Measurements of electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity are taken at one or more extremities of the subject such as the calf, ankle, forearm, thigh, fingers and toes. The physiological parameters for which baseline measurements were obtained are then monitored to detect changes from the baseline measurements that indicate blood volume imbalances. A preferred embodiment comprises computing a baseline blood volume index from the baseline value measurements of each parameter to be monitored and then carrying out the step of monitoring by obtaining real time (current) value measurements of these parameters which are inputted into an algorithm which computes a real time (current) blood volume index based upon the differences between the baseline and real time (current) value measurements.

Aspects of the disclosure relate to methods, systems, and computer-readable storage media, that are useful for characterizing subjects having cancer. The disclosure is based, in part, on methods for immunoprofiling a cancer subject and the subject's prognosis and / or likelihood of responding to an immunotherapy based upon analysis of leukocyte populations in the peripheral blood of the subject.

The invention belongs to the technical field of physiological information measurement, and provides a measurement system and method based on multi-modal physiological information and a wearable device, and the system collects various different types of physiological signals including optical signals through a signal collection module; physiological information such as heart driving force, peripheral blood flow state and tissue volume change is reflected respectively or synergistically; multi-modal physiological features are extracted through the feature extraction module, individual physiological condition parameter vectors containing multiple information are constructed through the individual modeling module, and finally physiological parameter measurement results are obtained through the parameter calculation module by means of a neural network model trained by introducing a physiological consistency constraint mechanism. According to the scheme, the defects that a single signal is prone to being interfered and information is limited can be overcome through multi-modal physiological information fusion, the stability and accuracy of measurement are improved, personalized modeling and physiological consistency constraints are matched, the neural network model conforms to the physiological mechanism while keeping the data driving expression capacity, and the method has wide application scenes.