The invention discloses an intrusion prevention system for a vehicle-mounted information system. The intrusion prevention system comprises a power transmission system, an electric power steering system, an electronic stability control system, an instrument panel, a diagnostic system, a vehicle body control system, a sensor, an accelerator, a multimedia system and a vehicle-mounted mobile phone. The power transmission system, the electric power steering system, the electronic stability control system, the vehicle body control system and the multimedia system are connected with the diagnostic system through a gateway, the diagnostic system is connected with the vehicle-mounted mobile phone, the instrument panel is connected with the vehicle body control system and the power transmission system, and the sensor and the accelerator are connected with the vehicle body control system. Compared with the prior art, the powerful calculation capability and storage capability of the mobile phone are utilized, the mobile phone is set as an intrusion prevention center; the formulation of safety regulations, storage of a virus reservoir, the judgment of security situation awareness and the connection with a cloud are all finished through the mobile phone, users' life and property safety is guaranteed, and the intrusion prevention system has popularization and application values.