4 results about "Salmonella gloucester" patented technology

The application belongs to the field of feed additives, and particularly discloses application of sodium butyrate in preparation of a feed additive against chicken white dysentery Salmonella, and sodium butyrate is added in chicken basic feed as the feed additive against chicken white dysentery Salmonella; the addition of sodium butyrate in chicken basic feed can significantly reduce the bacterial load of chicken white dysentery Salmonella infection in chicken liver and spleen, significantly increase the ratio of villus length to crypt depth of the cecum of chicken infected with chicken white dysentery Salmonella, and improve the intestinal absorption capacity; the content of CD3+ T cells, TCR+ T cells, macrophages and B cells in the liver of chicken infected with chicken white dysentery Salmonella can be significantly reduced; and then the body weight of chicken infected with chicken white dysentery Salmonella is significantly increased, and the survival rate of chicken infected with chicken white dysentery Salmonella is increased. In summary, the addition of sodium butyrate in chicken basic feed can enhance the resistance to chicken white dysentery Salmonella infection.

The application discloses a kind of attenuated salmonella load adjuvant nano combination medicine, the combination medicine is modified to bacterial surface by means of amino and carboxyl condensation reaction, adamantane is simultaneously modified to adjuvant nano medicine surface using diselenium dynamic bond, then the host-guest interaction of adamantane and cyclodextrin is used to assemble two, and then nano medicine is stably combined on the surface of attenuated salmonella.Diselenium dynamic bond can be broken by ultrasound response, so as to realize the effect of drug release.This combination medicine has the tumor targeting enrichment ability of bacteria and the release characteristics of adjuvant nanoparticles under the action of ultrasonic wave, can realize targeted delivery and deep penetration in tumor tissue, and obtain significant tumor inhibition effect under ultrasonic stimulation.The experimental results show that the combination medicine exhibits good therapeutic effect in inhibiting tumor growth, and has excellent biological safety.

The application relates to the technical field of molecular biology, in particular to an anti-enteritis Salmonella nanobody Nb122, application and preparation method thereof, and relates to the nucleotide sequence and amino acid sequence of the anti-enteritis Salmonella nanobody Nb122, and relates to the application of the anti-enteritis Salmonella nanobody Nb122 in preparing products for reducing the adhesion and invasion of enteritis Salmonella to IPEC-J2 cells, and relates to the preparation method of the anti-enteritis Salmonella nanobody Nb122. The anti-enteritis Salmonella nanobody provided in the technical scheme can reduce the adhesion and invasion of enteritis Salmonella to IPEC-J2 cells.

This invention discloses a *Bdellovibrio* strain and its application in the treatment of *Salmonella lysate*, belonging to the field of microbial technology. The strain, with accession number CCTCC NO:M 20232311, has been identified as a new species of the genus *Bdellovibrio* through multiphasic classification, including 16S rRNA gene analysis, average nucleotide similarity, digital DNA-DNA hybridization, and trapping diet. This invention also discloses a biocontrol agent containing this *Bdellovibrio* and its application in the treatment of *Salmonella lysate*. The *Bdellovibrio* strain HCB006 provided by this invention exhibits high lysis efficiency and strong environmental adaptability, and can be used as an antibiotic alternative for the biocontrol of *Salmonella* in food processing, aquaculture environments, and medical fields. It is of great significance for preventing the spread of dangerous pathogens and improving food health.