121results about How to "Achieve escape" patented technology

The invention discloses a compound with anthrone as a core and a use thereof. According to the compound, anthrone is a mother nucleus and is connected to an aromatic heterocyclic group so that molecular symmetry is destroyed, molecule crystallinity is destroyed, intermolecular aggregation is avoided and good film-forming performances are obtained. The compound as a light-emitting layer material is used for an organic light-emitting diode. An OLED device prepared from the compound has good photoelectric properties and can satisfy the requirements of the panel manufacturing companies.

The invention discloses a compound containing ketone and heterocyclic nitrogen and application thereof to an organic light-emitting device. The compound has the advantages of being not subjected to crystallization and aggregation easily and having good film-forming property, and rigid groups in molecules can improve heat stability of a material. The compound serving as a light-emitting layer material is applied to an organic light-emitting diode (OLED), and a manufactured OLED device has good photoelectric property and can meet the requirements of panel manufacturing enterprises.

The invention relates to a boron-containing organic compound and application of the boron-containing organic compound to an OLED device. The structure of the compound is shown as a general formula (1), the whole molecule of the compound is a large rigid structure, and the introduction of substituent groups reduces the planarity of a material, so the steric hindrance of the material is increased, the material is not easy to rotate, and a three-dimensional space structure is more stable; and therefore, the compound has higher glass transition temperature and molecular thermal stability. In addition, the HOMO and LUMO distribution positions of the compound are separated from each other, so the compound has appropriate HOMO and LUMO energy levels; and therefore, after the compound is applied to the OLED device, the luminous efficiency of the device can be effectively improved, and the service life of the device can be effectively prolonged.

The invention relates to the field of accessories and preparations with medicinal functions, in particular to a kind of oligopeptide-based pH-sensitive amphoteric ion lipid (I) or (II). In the invention, the derivatives of the oligopeptide amphoteric ion lipid have different surface charges under different pH conditions and can take relatively strong negative charges in a physiological environment with pH near neutrality so that the lipid has good blood compatibility; when the lipid reaches a tumor part, the surface charges of the oligopeptide amphoteric ion lipid are reversed in an acidulous tumor environment, so that the original electronegativity is reversed into electropositivity; and a carrier with positive charges is easily combined with the surface of a tumor cell, and the tumor cell targeting can be effectively realized through an endocytosis path. In lysosome, a cationic carrier continuously realizes a function of proton sponge or a function of splitting lysosome membranes, and the two functions can ensure the integrity of the carrier, so that the carrier can safely escape to cytoplast or other organelles.

The invention relates to a DCs vaccine based on phospholipid hybrid polymersome jointly encapsulating an antigen and dual immunoagonists, a preparation method and application thereof. The phospholipidhybrid polymersome which can jointly load a model antigen OVA and two types of TLR agonists (TLR7/8 and TLR4) is used for stimulation in vitro of the DCs so as to realize the effective phagocytosis of DCs cells. The rapid and long-term immunostimulatory effect on the DCs is achieved by the internal and external co-loading of the OVA antigen. The synergistic effect of the two types of TLR agonistssignificantly enhances the immune response after antigen stimulation; the phospholipid hybrid polymersome which jointly encapsulates the antigen and the dual immunoagonists can effectively promote the activation and maturation of the DCs, increases the level of cross-presentation, promotes the migration of the DC vaccine to secondary lymphoid organs, and produces a strong specific cytotoxic T lymphocytes (CTLs) killing effect, thereby effectively killing tumor cells and realizing the immunotherapy of the DCs vaccine on tumors.

The invention discloses a boron-containing multi-element heterocyclic organic compound and an application thereof to an OLED (organic light-emitting diode) device. The compound utilizes benzo six-membered rings as a core, and boron is located on the six-membered ring in the center. The compound has the characteristics that molecules are not prone to crystallization and aggregation and film-formingproperty is good. When the compound is utilized as a luminous layer material of the OLED device, current efficiency, power efficiency and external quantum efficiency of the device are greatly improved; besides, the service life of the device is obviously prolonged.

The invention relates to PH-sensitive targeted LPNs (lipid poly-L-histidine hybrid nanoparticles) for encapsulating anti-tumor drugs. The LPNs comprise raw materials in percentage by mass as follows:50%-80% of PHIS (poly-histidine) and 20%-50% of lipid (including lipid-PEG), wherein the lipid PEG accounts for 1%-100% of the total mass of lipid. A hydrophobic core consists of PHIS, and the surfaceis modified with polyethylene glycol and tumor targeted peptide. The PEGylated lipid surface has the characteristics of good biocompatibility, high stability and long in-vivo circulation. A histidinecore can encapsulate the hydrophobic anti-cancer drugs under the neutral condition, histidine is protonized in the tumor microenvironment to mediate the carrier potential to change from negative to near neutral, intake and endocytosis of a carrier arepromoted, the carrier mediates the lysosome to escape after endocytosis, the drugs are released rapidly, tumor cells are effectively killed, and accordingly, the problems that the PEGylated nano-carrier endocytosis efficiency is low and cannot release the drugs in cells effectively after endocytosis are solved. The surface of the carrier can bemodified with a tumor-specific antibody or ligand, the tumor targeting property is further improved, and the therapeutic effect is improved.

The invention discloses an organic compound taking pyridine as a core and application thereof to OLED. The organic compound has the characteristics that the molecules are not easy to crystallize and aggregate, and have good film-forming property. The rigid group in the compound molecule can improve the heat stability of materials. When the compound serving as a luminescent layer material is applied to OLED, manufactured OLED devices have good photoelectric property and can properly meet the requirements of panel manufacturing enterprises.

The invention provides an integrated central control platform vehicle door lock, which comprises an executor and a mechanical lock body, wherein the executor is integrated with the mechanical lock body, and comprises an inner rack for executing control over the mechanical lock body to realize locking, unlocking and opening functions of the mechanical lock body. The door lock is high in function integration degree, and also has basic mistake-proofing and emergency functions: 1, a mistaken locking prevention function (that is, a door can be automatically bounced to an unlocked state and cannot be locked when a key is not pulled out and carried out of a vehicle, and the phenomenon that the key is left behind in the vehicle and the door cannot be opened), and 2, a double-safety forced opening function.

The invention discloses a compound taking anthranone as a core and an application of the compound in organic electroluminescent devices. The compound has the characteristics that molecules are not prone to crystallization and not prone to aggregation and the film forming property is good, and the thermal stability of the material can be improved due to rigid radicals in the molecules. The compound disclosed by the invention is applied to the organic electroluminescent devices as a luminescent layer material, and manufactured organic electroluminescent devices have good photoelectric properties and can meet the requirements of panel manufacturing enterprises.

The invention discloses a pyridine-based five-membered-ring substituted compound and application thereof. The compound provided by the invention has the characteristics that the crystallization and the aggregation among molecules are difficult, and the compound has a favorable film-forming property. The heat stability of a material can be improved by rigid groups in the molecules of the compound provided by the invention; the compound provided by the invention is applied to OLEDs (Organic Light Emission Diodes) as a luminescent layer material; a made OLED appliance has favorable photoelectric properties, and can better meet the requirements of a panel manufacturing enterprise.

The invention discloses a compound adopting dimethylanthrone as a core, and an application thereof in organic electroluminescent devices. The compound adopting the dimethylanthrone as the core and heteroarylcarbazole as a branched chain has the characteristics of difficulty in intermolecular crystallization, difficulty in aggregation and good electrochemical stability. When the compound is used as the luminescent layer material of the organic electroluminescent devices, the current efficiency of the devices is greatly improved, and the life of the devices is obviously prolonged.

The invention discloses an organic electroluminescence compound with nitrogen-containing five-membered heterocycle as the core and application thereof. The compound has the nitrogen-containing five-membered heterocycle as the core, is not easy to crystallize between molecules and is not easy to aggregate, and has good film forming ability. The compound, used as a luminescent layer material, is applied to organic electroluminescent devices. An organic electroluminescent device by using the compound has good photoelectric property and can better meet application requirements of panel manufacturing enterprises.

The invention relates to an organic compound taking diboron as a core, a preparation method of the organic compound and application of the organic compound to an organic light-emitting device. The structure of the compound is shown as a general formula (1); the whole molecule of the organic compound with diboron as the core is of a large rigid structure, the introduction of branched chains reducesthe planarity of the material, the steric hindrance of the material is increased, the material is not easy to rotate, and the three-dimensional space structure is more stable, so that the compound has high glass transition temperature and molecular thermal stability; in addition, HOMO and LUMO distribution positions of the compound are separated from each other, so that the compound has appropriate HOMO and LUMO energy levels; therefore, after the compound is applied to the OLED device, the luminous efficiency of the device can be effectively improved, and the service life of the device can be effectively prolonged.

The invention discloses an organic aromatic compound and an application of the organic aromatic compound in an organic electroluminescent device, and the compound has good film forming ability. The compound as a luminescent layer material can be used on the organic electroluminescent device, the organic electroluminescent device by using the compound has good photoelectric property, and is suitable for and satisfies the application requirements of a panel manufacture enterprise.

The invention discloses a boron-containing organic electroluminescent compound and an application thereof on organic electroluminescent devices, and belongs to the technical field of semiconductors. The boron-containing organic electroluminescent compound has a structure shown in a general formula (1). The invention also discloses an application of the boron-containing organic electroluminescent compound on organic electroluminescent devices. When the compound is used as a luminescent layer material of an organic electroluminescent device, the current efficiency, the power efficiency and the external quantum efficiency of the device are greatly improved; and meanwhile, the service life of the device is obviously prolonged.

The invention discloses a boron-containing organic compound and an application thereof in an organic electroluminescent device. The compound takes a benzo five-membered ring as a core, and a boron element is located on a central five-membered ring; and the intermolecular crystallization and aggregation of the compound are not easy, and the compound has good film-forming abilities. When the compound is used as the luminescent layer material of an organic electroluminescent device, the current efficiency, power efficiency and external quantum efficiency of the device can be greatly improved; andthe service life of the device can be obviously prolonged as well.