The invention discloses a spirofluorene pyridine palladium nanoparticles and a preparation method thereof. The method is as below: adding a certain amount of metal salt solution into the organic ligand containing pyridine units, stirring for 1-3 h at a certain temperature, aging for 3-5 h, conducting centrifugal separation, washing and drying to obtain corresponding metal-ligand nanoparticles. The preparation process is simple, low in cost and suitable for mass production; and by using different solvents, controlling the amount of reactants, reaction time and temperature, the method achieves effective regulation on particle size and dispersion of spirofluorene pyridine palladium nanoparticles. The prepared spirofluorene pyridine palladium nanoparticles are functionalized nanoparticles containing palladium, have stable performance, can be used for the catalysis of C-C bond coupling reaction, and have high catalytic efficiency and yield reaching 90-99%. Therefore, the spirofluorene pyridine palladium nanoparticles have broad application prospects in the field of catalysis.