The invention discloses a large-span bridge safety performance real-time monitoring system based on big data. The large-span bridge safety performance real-time monitoring system comprises a detectionarea division module, a bearing pressure detection module, a wind power parameter acquisition module, a deformation displacement monitoring module, a water flow impact parameter detection module, a modeling analysis module, a parameter database, a central server, an early warning module and a display terminal. According to the large-span bridge safety performance real-time monitoring system basedon big data, by integrating the influence factors of bearing pressure, longitudinal wind power, deformation displacement and water flow impact force borne by the bridge, and combining a modeling analysis module to quantify the influence result of the influence factors on the bridge safety performance, the comprehensive safety factor of the bridge is counted, and the health condition of the bridgecan be comprehensively reflected; and by counting and evaluating the comprehensive safety coefficient of the bridge regularly, the related workers can master the safety dynamic development trend of the bridge, the reliable reference bases are provided for the maintenance of the bridge, and the service life of the bridge is prolonged.