The invention discloses a culture method for grouper fries. The culture method is characterized by comprising the following steps: 1, preparing for a culture pond, and arranging a water wagon in the culture pond; 2, preparing for culture water, placing the culture water into the culture pond in the step 1, and dissolving oxygen in the culture water; 3, hatching spawns, placing the spawns into a vessel for hatching, and placing the vessel into the culture pond, wherein the water in the vessel is culture water; 4, culturing fish fries, and placing the hatched fish fries into the culture pond forculture; and 5, separating the fish fries by sieving, catching and sieving the fish fries every 30 days, and culturing the fish fries in different ponds according to a specification that the sizes are unified. The culture method disclosed by the invention achieves the aims of increasing the survival rate of grouper fries and reducing the mutual killing and devouring phenomena by providing good water quality, regulating the water temperature, reasonably arranging the stocking density, fortifying the nutrition and increasing the vitality.