A prefabricated, modular enclosure comprising a plurality of plastic foam EPS components forming an integrated structure characterized by energy efficiency and ease of assembly. Wall panels, window panels, door panels, gable panels and roofing panels may be custom configured and glued together, utilizing adaptors on their sides and corner assemblies at intersections. The panels include major and minor channel struts that longitudinally penetrate the panel bodies, snugly lodging within receptive slots. The struts do not contact each other, and no portions of the struts traverses the panel thickness from inside to outside, thus minimizing thermal loss pathways. The wider, major reinforcement struts have offset portions spaced from interior panel surfaces that project interiorly of the enclosure and form a rigid mounting for interior finishing. The chase defined between the modular panels and the interior wall finishing, afforded by the offset struts, may house plumbing, wiring or the like.