The invention relates to an asymmetric through hole printed circuit board. The asymmetric through hole printed circuit board comprises a base layer, wherein the base layer is provided with a difference signal wire, an anti-pad and grounding through holes, the anti-pad is provided with three signal through holes, the three signal through holes are respectively provided with a transmission signal wire, end portions of the transmission signal wires are provided with connection pads, one end of the difference signal wire is bifurcated to form three opposite reception signal wires, end portions of the reception signal wires are provided with the connection pads, the grounding through holes are arranged between the adjacent transmission signal wires, and only two of the signal through holes are communicated with the difference signal wires through welding of the connection pads. The asymmetric through hole printed circuit board is advantaged in that good impedance continuity is realized, interference reduction is realized, and adjustment on signal through hole connection modes can be realized according to field demands.