37results about How to "Improve population quality" patented technology

A method and system for batch scheduling uniform parallel machines with different capacities based on an improved genetic algorithm are provided. The method is to solve the batch scheduling problem of uniform parallel machines with different capacities. Jobs are distributed to machines by an improved genetic algorithm, and a corresponding batching strategy and a batch scheduling strategy are proposed according to the natural of the problem to obtain a fitness value of a corresponding individual; then, the quality of the solution is improved by a local search strategy; and, a crossover operation is performed on a population based on the fitness of the solution, and the population is continuously updated by repetitive iteration to eventually obtain an optimal solution.

The invention discloses a method for reconstructing a distribution network after a fault. The method for reconstructing the distribution network after the fault comprises the following steps of: first, establishing a multistage target function for reconstructing the distribution network after the fault, and determining a constraint condition; and then, reconstructing the distribution network after the fault by using a non-dominated sorting genetic algorithm. According to the method, the non-dominated sorting genetic algorithm based on quick classification is used, a multi-target function is not required to be converted into a single-target function, and requirements on reconstruction after the fault are met. The multistage target function for reconstructing the distribution network after the fault meets basic requirements of the reconstruction after the fault, namely power supply to loads in a non-fault black-out area is recovered one by one as many as possible, the fault recovering time is as short as possible, and the damage to the distribution network after the reconstruction is as small as possible, so that the original intention and the target for the reconstruction after the fault can be embodied in an aspect of a mathematical model.

The invention belongs to the technical field of environmental chemical toxicity evaluation and specifically provides an evaluation technical method based on a transcriptome sequencing technology to analyze environmental chemicals to directionally induce and differentiate human embryonic stem cells into myocardial cell toxicity. The scheme for directionally inducing and differentiating the human embryonic stem cells into myocardial cells disclosed by the invention can be applied to screening myocardium development toxicity of environmental chemicals under environmental exposure dosage or crowdexposure dosage; by means of a human embryonic stem cell directional myocardial cell differentiating model optimized by the technical method disclosed by the invention, a risk evaluation system for embryo myocardium development toxicity of environmental chemical exposure can be established; the technical scheme can be popularized and applied to myocardium toxicity forecasting and evaluation of environmental chemicals, medicine and the like, so that theoretical basis is provided for early preventing CHD (Coronary Heart Disease), and contributions are made to promoting child health and improvingpopulation quality. Furthermore, transcriptome sequencing utilized by the technical method disclosed by the invention can define embryo myocardium development toxicity caused by environmental chemical exposure for the whole genome level.

The invention relates to a method for solving flexible job shop scheduling by an improved genetic algorithm based on a catastrophe mechanism, which introduces the catastrophe mechanism and improves the structure of the traditional genetic algorithm to realize flexible job shop scheduling. In order to balance global search and local search capabilities, a catastrophe mechanism and a large mutationprobability mechanism are introduced, and necessary disturbance is applied in an algorithm iteration process, so that the algorithm has a relatively large probability to jump out of local optimum. Meanwhile, on the algorithm initialization population, a difference degree threshold strategy is introduced, so that the diversity of the population is increased, and the population quality is improved;a difference degree threshold strategy is also introduced to genetic manipulation, and if the difference degree reaches a threshold, two layers are crossed and then mutated; otherwise, the two layersare crossed after variation, so that the occurrence of algorithm premature can be effectively prevented, the quality of a scheduling scheme is improved, and the method can be well applied to the fieldof job shop scheduling.

The invention discloses a chicken FABP1 gene molecular genetic marker related to chicken good production traits, which is a polymorphism site on a chicken FABP1 gene mononucleotide polymorphism sequence. The site is a base polymorphism site of which the 83rd position on the FABP1 gene sequence second exon is C or T, and has three genotypes (CC, CT and TT), wherein the TT type is a good slaughter trait molecular genetic marker for meat chickens. The invention also discloses application of the marker in auxiliary screening or prediction of meat chicken species with good slaughter traits. The experiment proves that the polymorphism and productivity of the specific enzyme digestion site are related, and most measurement indexes of the individuals with the genotype of TT are higher than those of the individuals with the genotype of CC or CT, which indicates that the individuals with the genotype of TT can be used as breeding hens for culturing chicken species with good slaughter traits.

The invention discloses an excellent slaughter trait molecular genetic marker of broiler chicken. The molecular genetic marker is a polymorphic site on a plin1 single nucleotide polymorphism sequence of broiler chicken; the site is a base polymorphic site with A or T on the 49th site of an eighth exon of the plin1 gene sequence, and shows three genotypes of AA, AT or TT; and the TT type is the excellent slaughter trait molecular genetic marker of broiler chicken. The invention further discloses an application of the marker in auxiliary screening or prediction of the broiler chicken variety with excellent slaughter traits. An experiment proves that the polymorphism of the specific restriction site is relevant to the production performance; the measurement indexes of the individual body of which the genotype is TT are higher than those of the individual bodies of which the genotypes are AA and AT; and the individual body of which the genotype is TT can be reminded to breed the broiler chicken with excellent slaughter traits as chicken.

The invention relates to a reagent for diagnosing microdeletion of Y chromosome and a PCR amplification method therefor. The reagent is prepared by the following steps: (1) respectively dissolving the primer dry powders with TE whose pH value is between 7 and 8 to obtain a 10pmol / ª–l solution, (2) charging the following components into the 24ª–l reaction system: sY87-F, sY87-R, sY143-F, sY143-R, ex2DAZ-F, ex2DAZ-R, RhEY-F, RhEY-R, 10x buffer solution, MgCl2, dNTPs, Taq enzyme. The PCR amplification method comprises: charging a DNA sample into the reagent, pre-denaturing the reagent at 94íµ for 8 minutes, then denaturing respectively at 94íµ, 50íµ, 72íµ for 1 minute, at last cooling the reagent to 15íµ after 32 times circulations. The invention can provide a stable, sensitive and quick diagnosis, and the experimental cost is only one-tenth as much as the price of the overseas relative kits.

An obstacle-type reading / writing posture corrector for student is composed of desk top, a obstacle bar with two legs, and two hinges for hinging two legs of obstacle bar onto desk top. Its application is also disclosed.

The invention belongs to the technical field of medical science and discloses a method for genetic testing in single cells by HRM (high resolution melting) and pyrosequencing. By high-throughput sequencing for haplotype analysis of a single-gene inheritance disease family, an analysis method for mutation detection and SNP (single nucleotide polymorphism) by adoption of a single-cell whole genome amplification product as a template on the basis of HRM and pyrosequencing is established. The method can be applied clinically directly to provide fast detection means for PGD (preimplantation genetic diagnosis) diagnosis of patients suffering from single gene inheritance diseases.

The invention discloses a detection method and detection kit for goat LMCD1 gene mononucleotide polymorphism sites. The method comprises the following steps: by using to-be-detected goat genome DNA (deoxyribonucleic acid) of containing LMCD1 gene as a template, carrying out PCR (polymerase chain reaction) amplification on the goat LMCD1 gene, and carrying out SSCP (single strand conformation polymorphism) polymorphism detection. The gene polymorphism sites comprise the following base polymorphisms: the 681st site of the goat LMCD1 gene is A or G; and the 2825th site of the goat LMCD1 gene is C or T. The invention provides a simple quick low-cost high-precision detection method, which can be conveniently applied to screening and detecting of genetic markers closely related to goat growth traits at the DNA level and can be used for assisted selection and molecular breeding of goat.

The invention discloses a construction method and application of an animal model suffering from fetal-origin adult osteoporosis. The construction method comprises: performing intragastric administration with 30-120 mg / kg / d of caffeine and 4-4.6 g / kg / d of ethanol on a rodent which has been pregnant for 9-20 days, performing subcutaneous injection with 1-2 mg / kg / d of nicotine or 0.2-1.2 mg / kg / d of dexamethasone, and allowing the mother rat to naturally give birth to offspring. After the offspring is naturally cultured to an adult, the phenomenon of bone mass peak reduction and osteoporosis in the elder period, which meets the clinical diagnosis standard, shows up, thereby obtaining a stable animal model suffering from fetal-origin adult osteoporosis. The animal model has symptom and pathologic change similar to that of human adult osteoporosis, and has important value for screening of explosion in multiple adverse intrauterine environments and research of pathogenesis and control strategy of fetal-origin adult osteoporosi.

The invention discloses an Internet of Things workshop scheduling method based on an NSGA-II algorithm. The method comprises the following steps: respectively establishing three objective functions based on total processing time, total production cost and longest operation time of single equipment; taking the reciprocal of the three objective functions as a fitness function; establishing a workshop scheduling model according to the objective function and the fitness function; and solving the workshop scheduling model based on an NSGA-II algorithm to obtain an optimal workshop scheduling scheme. According to the Internet of Things workshop scheduling method based on the NSGA-II algorithm, local convergence can be avoided, the population quality can be improved, and a better multi-objective optimal solution can be obtained.

The invention relates to a risk assessment system of pre-pregnancy antenatal health and belongs to the field of risk assessment pre-pregnancy antenatal health. According to pre-pregnancy antenatal health examination information of a pre-pregnancy antenatal health examination assessment object, risk factors are automatically identified; targeted personalized consultation and guiding advices and gestation suggestions are given out; and high-risk groups are determined. The system comprises a file management module, an assessment module, a classification module and an output module.

A non-linear fetal heart rhythm monitor is disclosed. Its monitoring method includes such steps as taking the cardiac sound signals of fetus by ultrasonic Doppler sensor, extracting the envelope of audio signals, transmitting it to A / D interface card PC6360, A / D conversion, and transmitting the converted result to computer aided non-linear analyzing processor which has man-machine interaction interface and the working interface and analyzing software of non-linear kinetic analysis software package.

The invention discloses a sexual dysplasia-related gene capture kit and an application thereof. The sexual dysplasia-related gene capture kit carries out target region sequencing analysis on the wholeexon group or the sexual dysplasia-related genome (respectively accounting for 1% and 0.01% of the whole genome) of a patient with hereditary dysplasia, most pathogenic mutation information of the disease is captured, and the kit has the advantages of small required sample amount, low cost and high throughput, can detect many samples, and promotes discovery of new pathogenic variation of hereditary dysplasia. The sexual dysplasia-related gene mutation site selected by the invention covers common hot spot mutation and other unusual mutation sites of Chinese people. The high throughput of the kit makes sexual dysplasia-related genes in people comprehensively screened, so the kit is of great significance to improving population quality and benefiting the society.

The present invention discloses one kind of protein related to growth of human air and teeth and its coding gene. The protein related to growth of human air and teeth is protein of EDA with place 65 amino acid from the amino end mutated from arginine into glycine. The protein related to growth of human air and teeth and its coding gene of the present invention provide essentiality and possibilityfor the genetic diagnosis of X-linked congenital tooth deficiency disease, such as in antemarital consultation, DNA based antenatal diagnosis, etc. and this can reach the aim of raising population quality.

The invention relates to the technical field of chemical analysis and detection, and in particular relates to a detection kit based on a tandem mass spectrum non-derivatization method. The detection kit comprises an isotope labeled amino acid standard substance mixture, an isotope labeled acyl carnitine standard substance mixture, an extract liquor and a flow phase. The detection kit based on the tandem mass spectrum non-derivatization method is characterized in that the extract liquor consists of methyl alcohol, water and saturated monocarboxylic acid, wherein the volume ratio of the methyl alcohol to the water to the saturated monocarboxylic acid is 1000: (1-50): (0.01-2). The detection kit based on the tandem mass spectrum non-derivatization method provided by the invention is high in flexibility and accuracy rate, is simple to operate, and has important significance for improving the diagnosis level of metabolic diseases, lowering the burden of society and families and improving the quality of population.

The invention provides a block partition design method for an ultra-high-speed maglev train. The block partition design method comprises the following steps: preparing data; performing partition division; building block time models of different types of partitions of the ultra-high-speed maglev train; establishing a block partition division multi-objective optimization model; solving by adopting an improved non-dominated sorting genetic algorithm with an elitist strategy to obtain all non-dominated solutions; according to the method, the bottleneck links of the adjacent trains can be positioned more accurately and quickly, and the line design capability can be evaluated more scientifically and accurately; the calculation complexity can be reduced, the sampling space can be expanded, the diversity of populations can be maintained, and the advantages and disadvantages of solutions can be well guaranteed; meanwhile, by means of the method, an operation time margin model is added in the block time model of each partition, and the block partition optimization design result under the disturbance condition of the ultra-high-speed maglev train can be further calculated.

The invention discloses a sexual development abnormality-related gene capture kit and application thereof. The sexual developmental abnormality-related gene capture kit provided by the present invention is to perform target region sequencing on the whole exome or sexual developmental abnormality-related genome (accounting for 1% and 0.01% of the whole genome respectively) of patients with hereditary sexual developmental abnormality Analysis, which captures most of the pathogenic mutation information of the disease, has the advantages of small sample size, low cost, and high throughput, and can detect more samples, which promotes the identification of new pathogenic mutations of genetic abnormalities. Find. The genetic mutation sites related to abnormal sexual development selected in the present invention cover common hotspot mutations and other uncommon mutation points in Chinese. The high-throughput of the kit can comprehensively screen the genes related to abnormal sexual development in the population, which is of great significance for improving the quality of the population and benefiting the society.

The invention discloses a vaccine inoculation time deduction plate for children within one year old. The vaccine inoculation time deduction plate is characterized by designing a small circular plane plate 1, drawing six concentric circles in the small plate 1, dividing all concentric circles into twelve equal arc surfaces 2 on a circumference, respectively labeling vaccine names including "hepatitis B", "poliomyelitis", "diphtheria-pertussis-tetanus", "measles", "Japanese encephalitis", "group A" and "bacillus calmette-guerin" words in a radial column of the arc surfaces 2 according to a sequence from outside to inside, respectively digging a hole 4 in other arc surfaces 2 corresponding to the vaccine names according to a vaccine usage time and then arranging a big plate, drawing seven concentric circles in the big plate, writing "intramuscular injection", "oral administration", "intramuscular injection", "subcutaneous injection", "subcutaneous injection", "subcutaneous injection" and "intracutaneous injection" words on each of the concentric circles, overlapping the small plate 1 to the big plate 5, and arranging a connecting shaft 3 on the small plate 1 and the big plate 5. By rotating the small plate 1, the words displayed in the holes 4 are an inoculation sequence, an inoculation method and an inoculation time.

The invention provides an in-vitro diagnostic kit of Leber hereditary optic neuropathy (LHON). The in-vitro diagnostic kit comprises SEQIDNO.1-12. The in-vitro diagnostic kit provides a rapid, accurate and cheap genetic level detection means for the clinic diagnosis of the LHON, can realize the prevention and early-stage timely diagnosis of the LHON, can find high risk group, improves the diagnosis rate of the HLON, can effectively realize antenatal genetic counseling and premarital counseling, improves the population quality, and reduces the family and national medical expenditure.

The invention discloses an intrauterine surgical procedure which comprises the steps of preoperative preparation, anaesthesia, operation and postoperative management. The intrauterine surgical procedure is applied to clinical treatment gradually, can rectify certain congenital monstrosity in early course as well as in an intrauterine period when the operative effect is best and can avoid certain irreversible intrauterine damage so as to achieve permanent curative effect. Adopting the intrauterine surgical procedure of the invention can greatly lower disability rate, mitigate the permanent undesirable impact on society and family after an oaf is born, provide chances to correct certain congenital deformities, in particular to serious or lethal deformities for human, play a great role in promoting population quality and facilitating secondary prevention and reduce birth defect to the largest extend.

The invention provides a novel triploid syndrome detection kit. The novel triploid syndrome detection kit comprises a primer combination, a probe combination, PCR reaction liquid and Taq polymerase, the kit comprises DNA ligase, terminal transferase, dNTPs (deoxyribonucleoside triphosphates) and reaction buffer solution, the sequences of the primer combination are as shown in SEQ ID NO. 1 to SEQ ID NO. 10; the probe combination is a whole genome copy number abnormal probe. According to the invention, the fetus triploid syndrome is safely, noninvasively, accurately, quickly and economically detected from maternal peripheral blood in an ultra-early stage, and a PCR technology is adopted, so that the requirement on the pregnancy time of a pregnant woman is relatively short; the method has the advantages that a pregnant woman of 8-10 weeks can carry out ultra-early screening, the quantity demanded of samples is small, only 2mL of plasma samples are needed, the operation process is simple and rapid, the detection period is short, data analysis is visual and convenient, the cost is only half of that of an NGS method, and non-invasive prenatal ultra-early screening can be completed in a short time.

The invention relates to a technology for diagnosing an amino acid metabolism metabolic disorder disease, and in particular relates to a maternal amniotic fluid phenylalanine detection method for phenylketonuria (PKU) antenatal diagnosis. The method comprises the following steps of: firstly, carrying out ultrasonic treatment, centrifugal treatment and filtering on collected maternal amniotic fluid; taking filtered liquid supernatant as a sample to be tested; and utilizing an internal standard method to detect the content of phenylalanine in amniotic fluid filtering liquid. By analyzing the content of the phenylalanine in the maternal amniotic fluid, whether a fetus in a parent body is a PKU patient or not can be promoted. Therefore, the maternal amniotic fluid phenylalanine detection method reduces the happening of the disease, completely removes the damages of the disease and improves the population quality.

The invention relates to a primer group, a method and a kit for detecting the triploids of a fetus by virtue of plasma free DNS in maternal peripheral blood, wherein the DNA is selected from human No. 21, No. 18 and No. 13 chromosomes, 300 pairs of sequence specific primers are designed with regard to the No. 21, No. 18 and No. 13 chromosomes respectively, each pair of the sequence specific primers comprises a forward primer, a reverse primer and a middle primer, and the gene sequence numbers of the primers are SEQ ID NO: 1-2700. The primer group, the method and the kit disclosed by the invention have the following beneficial effects: the triploids of the fetus are detected by the method disclosed by the invention, the detection is non-invasive detection without a threat on the health of the fetus, diagnosis and detection are high in accuracy and low in expense, flow and data analysis are simple and convenient, and PCR reaction condition requirements are not rigorous; the primer group, the method and the kit are wide in applicability, can be used for promoting the popularization of non-invasive screening for a trisomic syndrome, and are conductive to improving the population quality of China.

The invention relates to a gene mutation detection kit for human glucose-6-phosphate dehydrogenase deficiency, which comprises probes with sequences shown in SEQ NO.1-382. The present invention analyzes the distribution of 500 G6PD gene positive mutation sites in China, and combines the human gene mutation database (Human Gene Mutation Database, HGMD) database and gene mutation hotspot data in Europe and the United States to more comprehensively summarize the G6PD gene mutation hotspots, To solve the genetic mutation detection problem of nearly 99% of patients with G6PD deficiency, and realize the rapid and effective genetic diagnosis of G6PD deficiency disease.

A non-linear fetal heart rhythm monitor is disclosed. Its monitoring method includes such steps as taking the cardiac sound signals of fetus by ultrasonic Doppler sensor, extracting the envelope of audio signals, transmitting it to A / D interface card PC6360, A / D conversion, and transmitting the converted result to computer aided non-linear analyzing processor which has man-machine interaction interface and the working interface and analyzing software of non-linear kinetic analysis software package.

The invention discloses a primer group for detecting BMPR1B gene mutation. The primer group comprises a BMPR1B gene first to tenth exon regions, a PCR (polymerase chain reaction) amplification primer group corresponding to 3'UTR, 5'UTR and a starter and a PCR sequence testing primer. The invention also discloses a purpose of the primer group and a kit containing the primer group. The primer group can be used for specifically identifying whether the BMPR1B gene mutation occurs or not; the accuracy and the uniqueness of the detection result are ensured.