37results about How to "Improve population quality" patented technology

The invention discloses a method for reconstructing a distribution network after a fault. The method for reconstructing the distribution network after the fault comprises the following steps of: first, establishing a multistage target function for reconstructing the distribution network after the fault, and determining a constraint condition; and then, reconstructing the distribution network after the fault by using a non-dominated sorting genetic algorithm. According to the method, the non-dominated sorting genetic algorithm based on quick classification is used, a multi-target function is not required to be converted into a single-target function, and requirements on reconstruction after the fault are met. The multistage target function for reconstructing the distribution network after the fault meets basic requirements of the reconstruction after the fault, namely power supply to loads in a non-fault black-out area is recovered one by one as many as possible, the fault recovering time is as short as possible, and the damage to the distribution network after the reconstruction is as small as possible, so that the original intention and the target for the reconstruction after the fault can be embodied in an aspect of a mathematical model.

The invention belongs to the technical field of environmental chemical toxicity evaluation and specifically provides an evaluation technical method based on a transcriptome sequencing technology to analyze environmental chemicals to directionally induce and differentiate human embryonic stem cells into myocardial cell toxicity. The scheme for directionally inducing and differentiating the human embryonic stem cells into myocardial cells disclosed by the invention can be applied to screening myocardium development toxicity of environmental chemicals under environmental exposure dosage or crowdexposure dosage; by means of a human embryonic stem cell directional myocardial cell differentiating model optimized by the technical method disclosed by the invention, a risk evaluation system for embryo myocardium development toxicity of environmental chemical exposure can be established; the technical scheme can be popularized and applied to myocardium toxicity forecasting and evaluation of environmental chemicals, medicine and the like, so that theoretical basis is provided for early preventing CHD (Coronary Heart Disease), and contributions are made to promoting child health and improvingpopulation quality. Furthermore, transcriptome sequencing utilized by the technical method disclosed by the invention can define embryo myocardium development toxicity caused by environmental chemical exposure for the whole genome level.

The invention discloses a chicken FABP1 gene molecular genetic marker related to chicken good production traits, which is a polymorphism site on a chicken FABP1 gene mononucleotide polymorphism sequence. The site is a base polymorphism site of which the 83rd position on the FABP1 gene sequence second exon is C or T, and has three genotypes (CC, CT and TT), wherein the TT type is a good slaughter trait molecular genetic marker for meat chickens. The invention also discloses application of the marker in auxiliary screening or prediction of meat chicken species with good slaughter traits. The experiment proves that the polymorphism and productivity of the specific enzyme digestion site are related, and most measurement indexes of the individuals with the genotype of TT are higher than those of the individuals with the genotype of CC or CT, which indicates that the individuals with the genotype of TT can be used as breeding hens for culturing chicken species with good slaughter traits.

The invention belongs to the technical field of medical science and discloses a method for genetic testing in single cells by HRM (high resolution melting) and pyrosequencing. By high-throughput sequencing for haplotype analysis of a single-gene inheritance disease family, an analysis method for mutation detection and SNP (single nucleotide polymorphism) by adoption of a single-cell whole genome amplification product as a template on the basis of HRM and pyrosequencing is established. The method can be applied clinically directly to provide fast detection means for PGD (preimplantation genetic diagnosis) diagnosis of patients suffering from single gene inheritance diseases.

The invention discloses a detection method and detection kit for goat LMCD1 gene mononucleotide polymorphism sites. The method comprises the following steps: by using to-be-detected goat genome DNA (deoxyribonucleic acid) of containing LMCD1 gene as a template, carrying out PCR (polymerase chain reaction) amplification on the goat LMCD1 gene, and carrying out SSCP (single strand conformation polymorphism) polymorphism detection. The gene polymorphism sites comprise the following base polymorphisms: the 681st site of the goat LMCD1 gene is A or G; and the 2825th site of the goat LMCD1 gene is C or T. The invention provides a simple quick low-cost high-precision detection method, which can be conveniently applied to screening and detecting of genetic markers closely related to goat growth traits at the DNA level and can be used for assisted selection and molecular breeding of goat.

The invention discloses a construction method and application of an animal model suffering from fetal-origin adult osteoporosis. The construction method comprises: performing intragastric administration with 30-120 mg/kg/d of caffeine and 4-4.6 g/kg/d of ethanol on a rodent which has been pregnant for 9-20 days, performing subcutaneous injection with 1-2 mg/kg/d of nicotine or 0.2-1.2 mg/kg/d of dexamethasone, and allowing the mother rat to naturally give birth to offspring. After the offspring is naturally cultured to an adult, the phenomenon of bone mass peak reduction and osteoporosis in the elder period, which meets the clinical diagnosis standard, shows up, thereby obtaining a stable animal model suffering from fetal-origin adult osteoporosis. The animal model has symptom and pathologic change similar to that of human adult osteoporosis, and has important value for screening of explosion in multiple adverse intrauterine environments and research of pathogenesis and control strategy of fetal-origin adult osteoporosi.

The invention discloses an Internet of Things workshop scheduling method based on an NSGA-II algorithm. The method comprises the following steps: respectively establishing three objective functions based on total processing time, total production cost and longest operation time of single equipment; taking the reciprocal of the three objective functions as a fitness function; establishing a workshop scheduling model according to the objective function and the fitness function; and solving the workshop scheduling model based on an NSGA-II algorithm to obtain an optimal workshop scheduling scheme. According to the Internet of Things workshop scheduling method based on the NSGA-II algorithm, local convergence can be avoided, the population quality can be improved, and a better multi-objective optimal solution can be obtained.

The invention relates to a risk assessment system of pre-pregnancy antenatal health and belongs to the field of risk assessment pre-pregnancy antenatal health. According to pre-pregnancy antenatal health examination information of a pre-pregnancy antenatal health examination assessment object, risk factors are automatically identified; targeted personalized consultation and guiding advices and gestation suggestions are given out; and high-risk groups are determined. The system comprises a file management module, an assessment module, a classification module and an output module.

The invention discloses a sexual dysplasia-related gene capture kit and an application thereof. The sexual dysplasia-related gene capture kit carries out target region sequencing analysis on the wholeexon group or the sexual dysplasia-related genome (respectively accounting for 1% and 0.01% of the whole genome) of a patient with hereditary dysplasia, most pathogenic mutation information of the disease is captured, and the kit has the advantages of small required sample amount, low cost and high throughput, can detect many samples, and promotes discovery of new pathogenic variation of hereditary dysplasia. The sexual dysplasia-related gene mutation site selected by the invention covers common hot spot mutation and other unusual mutation sites of Chinese people. The high throughput of the kit makes sexual dysplasia-related genes in people comprehensively screened, so the kit is of great significance to improving population quality and benefiting the society.

The present invention discloses one kind of protein related to growth of human air and teeth and its coding gene. The protein related to growth of human air and teeth is protein of EDA with place 65 amino acid from the amino end mutated from arginine into glycine. The protein related to growth of human air and teeth and its coding gene of the present invention provide essentiality and possibilityfor the genetic diagnosis of X-linked congenital tooth deficiency disease, such as in antemarital consultation, DNA based antenatal diagnosis, etc. and this can reach the aim of raising population quality.

The invention provides a block partition design method for an ultra-high-speed maglev train. The block partition design method comprises the following steps: preparing data; performing partition division; building block time models of different types of partitions of the ultra-high-speed maglev train; establishing a block partition division multi-objective optimization model; solving by adopting an improved non-dominated sorting genetic algorithm with an elitist strategy to obtain all non-dominated solutions; according to the method, the bottleneck links of the adjacent trains can be positioned more accurately and quickly, and the line design capability can be evaluated more scientifically and accurately; the calculation complexity can be reduced, the sampling space can be expanded, the diversity of populations can be maintained, and the advantages and disadvantages of solutions can be well guaranteed; meanwhile, by means of the method, an operation time margin model is added in the block time model of each partition, and the block partition optimization design result under the disturbance condition of the ultra-high-speed maglev train can be further calculated.

The invention discloses an intrauterine surgical procedure which comprises the steps of preoperative preparation, anaesthesia, operation and postoperative management. The intrauterine surgical procedure is applied to clinical treatment gradually, can rectify certain congenital monstrosity in early course as well as in an intrauterine period when the operative effect is best and can avoid certain irreversible intrauterine damage so as to achieve permanent curative effect. Adopting the intrauterine surgical procedure of the invention can greatly lower disability rate, mitigate the permanent undesirable impact on society and family after an oaf is born, provide chances to correct certain congenital deformities, in particular to serious or lethal deformities for human, play a great role in promoting population quality and facilitating secondary prevention and reduce birth defect to the largest extend.

The invention provides a novel triploid syndrome detection kit. The novel triploid syndrome detection kit comprises a primer combination, a probe combination, PCR reaction liquid and Taq polymerase, the kit comprises DNA ligase, terminal transferase, dNTPs (deoxyribonucleoside triphosphates) and reaction buffer solution, the sequences of the primer combination are as shown in SEQ ID NO. 1 to SEQ ID NO. 10; the probe combination is a whole genome copy number abnormal probe. According to the invention, the fetus triploid syndrome is safely, noninvasively, accurately, quickly and economically detected from maternal peripheral blood in an ultra-early stage, and a PCR technology is adopted, so that the requirement on the pregnancy time of a pregnant woman is relatively short; the method has the advantages that a pregnant woman of 8-10 weeks can carry out ultra-early screening, the quantity demanded of samples is small, only 2mL of plasma samples are needed, the operation process is simple and rapid, the detection period is short, data analysis is visual and convenient, the cost is only half of that of an NGS method, and non-invasive prenatal ultra-early screening can be completed in a short time.

The invention relates to a technology for diagnosing an amino acid metabolism metabolic disorder disease, and in particular relates to a maternal amniotic fluid phenylalanine detection method for phenylketonuria (PKU) antenatal diagnosis. The method comprises the following steps of: firstly, carrying out ultrasonic treatment, centrifugal treatment and filtering on collected maternal amniotic fluid; taking filtered liquid supernatant as a sample to be tested; and utilizing an internal standard method to detect the content of phenylalanine in amniotic fluid filtering liquid. By analyzing the content of the phenylalanine in the maternal amniotic fluid, whether a fetus in a parent body is a PKU patient or not can be promoted. Therefore, the maternal amniotic fluid phenylalanine detection method reduces the happening of the disease, completely removes the damages of the disease and improves the population quality.

The invention discloses a primer group for detecting BMPR1B gene mutation. The primer group comprises a BMPR1B gene first to tenth exon regions, a PCR (polymerase chain reaction) amplification primer group corresponding to 3'UTR, 5'UTR and a starter and a PCR sequence testing primer. The invention also discloses a purpose of the primer group and a kit containing the primer group. The primer group can be used for specifically identifying whether the BMPR1B gene mutation occurs or not; the accuracy and the uniqueness of the detection result are ensured.