The invention discloses a one glass solution (OGS) capacitive touch screen which comprises a PET protective film, optical cement, an ITO functional piece and a soft circuit board, wherein the PET protective film, the optical cement and the ITO functional piece are arranged in an up-down overlapping mode, and the soft circuit board is attached to the upper surface or the lower surface of the ITO functional piece. The invention further discloses a manufacturing method of the OGS capacitive touch screen. The manufacturing method of the OGS capacitive touch screen includes the following steps: 1, preparing the PET protective film, and preparing the soft circuit board; 2, converting a functional pattern into a laser path; 3, leading the laser path into a laser device; 4, etching a large-piece ITO plate by using the laser device; 5, dividing the large-piece ITO plate and forming the single ITO functional piece in a splicing and combined mode; 6, connecting the soft circuit board to the ITO functional piece, and carrying out electrical logging on functions; 7, splicing the ITO functional piece and the PET protective film; 8, carrying out the electrical logging on finished products. The OGS capacitive touch screen and the manufacturing method of the OGS capacitive touch screen are rich in color, capable of preparing soft touch screens, simplified in production procedure, less in investment of production lines and environment-friendly in production, and products have higher competitiveness.