The invention discloses a process for synthesizing butanone oxime ethyl ether through continuous microtube reaction. The process adopts continuous microtube reaction technology, under the conditions of temperature 30-45℃, pressure 0.1MPa and strong base, butanone oxime and diethyl sulfate are reacted to directly synthesize butanone oxime ethyl ether; the strong base is hydrogen Sodium oxide, potassium hydroxide or alcohol amine compounds. In this process, diethyl sulfate, lye and butanone oxime are respectively fed by precision micropumps, butanone oxime is mixed with lye and diethyl sulfate in turn, and then reacted in a microtube reactor. After the heater, it is condensed and collected at low temperature, the chromatographic separator is left to stand for stratification, the water phase is extracted and separated by a micro-extraction tower, and the oil phase product containing butanone oxime ether is purified by rectification in a rectification tower to obtain the final product butanone oxime ether. The process has high selectivity of butanone oxime ethyl ether, can significantly enhance mass transfer and heat transfer, effectively avoid the hydrolysis of diethyl sulfate, has simple process, long stable operation time, low cost, is easy to scale up, and meets the requirements of industrial production.