The invention relates to an intelligent ultrasonic cleaning system and method for an air distribution pipeline. The system comprises a heat recovery fresh air machine, an air pipe closing valve, an air pipe, an air pipe heating, an adjustable exterior wall shutter, an intake air filter, an outdoor air quality sensor, an outdoor temperature sensor, an air conditioning board, a drainage exit, a heating water supply pipe, a heating water return pipe, an exhaust outlet, a power supply and an ultrasonic generator, an ultrasonic vibration submarine harbor, an ultrasonic vibration submarine, a closedconnector, a water-escape electrically operated valve, a water escape pipe, an ultrasonic transmission, power supply and signal line, a system controller and a water leakage sensor. The invention also relates to the intelligent ultrasonic cleaning method for the air distribution pipeline. The effect of water cleaning and cleaning liquid cleaning of the system and the method is far between than that of dry cleaning.