The invention discloses a drilling and high-pressure grouting construction method for an uplift pile. The drilling and high-pressure grouting construction method includes the steps that step1, construction preparation is performed; step2, paying-off positioning is performed; step3, a drilling machine is in place; step4, drilling is performed; step5, casing running is performed; step6, drilling is continued to a designed elevation; step7, hole sealing grouting is performed; step8, concrete pouring is performed; step9, steel bars are inserted; step10, drilling tool and earthwork clearing is performed. The drilling and high-pressure grouting construction method has the advantages that in the drilling process, noise is low, vibration is small, the construction period is short, influences on surrounding traffic and social activities are small, and the construction method is a green construction method; while the uplift bearing capacity of a foundation is improved, the construction method saves a lot of resources and energy, and has remarkable social benefits.