The invention discloses a piezoelectric ceramic driver pre-tightening device. A thread column is rotatably arranged on a base, the thread column and a piezoelectric ceramic driver are arranged in thesame direction, one end of the thread column can abut against the end of the piezoelectric ceramic driver, the thread column is driven through a worm gear, the thread column is sleeved with the worm gear in a threaded manner, a worm and the worm gear are in threaded fit to form a worm gear and worm mechanism, when the worm rotates, the worm gear is driven to rotate, due to the fact that the two axial ends of the worm gear are limited by a base in an ejecting manner, when the worm gear rotates, the axial position is kept unchangeable, the worm gear and the thread column are in thread fit, whenejecting is needed, the worm is twisted, the thread column gets close to the piezoelectric ceramic driver, one end of the piezoelectric ceramic driver is in contact with the thread column, the other end of the piezoelectric ceramic driver makes contact with a work mechanism, pressure is applied through the thread column, the piezoelectric ceramic driver is tightly attached to the work mechanism, the worm gear and worm mechanism has the self-locking characteristics, the worm gear is driven only by the worm, the worm gear cannot reversely drive the worm to rotate, and the loosening possibility is removed.