How to Mannan-binding lectin?

Fused pyrimidines as MASP-2 inhibitors,dsRNA molecules for regulating MASP2 gene activity,Modulators of mannan-binding lectin-associated protease,DsRNA molecule for regulating and controlling MASP2 gene activity

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4 results about "Mannan-binding lectin" patented technology

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Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as an opsonin and via the lectin pathway.

Fused pyrimidines as MASP-2 inhibitors

PendingJP2025541737AOrganic active ingredientsSenses disorderSerine Protease InhibitorsOrganic chemistry

The present disclosure provides synthetic compositions useful as inhibitors of mannan-binding lectin-associated serine protease-2 (MASP-2), including compositions that selectively inhibit MASP-2 over thrombin, as well as methods for their production and use.

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Owner:OMEROS CORP

dsRNA molecules for regulating MASP2 gene activity

PendingJP2026520116AOrganic active ingredientsGenetic material ingredientsDiseaseNucleotide

The present invention provides a double-stranded RNA used to suppress the expression of mannan-binding lectin-related serine protease 2 (MASP2) in cells, cells containing the nucleotide encoding the same, and a method for treating a disease or condition mediated by or related to MASP2 expression in a subject using the dsRNA or cells.

dsRNA molecules for regulating MASP2 gene activity

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Owner:RONA THERAPEUTICS INC +1

Modulators of mannan-binding lectin-associated protease

PCT designated stageWO2025207595A8Organic active ingredientsSenses disorderGlycanPharmaceutical drug

Provided herein are modulators of MASP represented by Formula (I); and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions comprising the compounds of Formula (I) and uses for treating conditions associate with modulation of MASP.

Modulators of mannan-binding lectin-associated protease

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Owner:ENTASIS THERAPEUTICS INC

DsRNA molecule for regulating and controlling MASP2 gene activity

PendingCN121175420AOrganic active ingredientsGenetic material ingredientsDiseaseNucleotide

Provided are a double-stranded RNA for inhibiting the expression of mannan-binding lectin-associated serine protease 2 (MASP2) in a cell, a cell comprising a nucleotide encoding the same, and a method of using the dsRNA or cell to treat a disease or condition mediated or associated with the expression of MASP2 in a subject.

Owner:CHENGDU CONMED BIOSCI CO LTD +1