The invention discloses a plant leaf wilting simulation method based on a physical model, relating to the field of computer simulation technology. The method comprises the following steps of: constructing a voxel set of a three-dimensional plant leaf model, wherein the voxel set comprises a plurality of hexahedron units used for simulating plant leaf mesophyll internal cells; converting the voxel set into a mass-spring model; after applying an external force to the mass-spring model, simulating the displacement of each peak in the hexahedron units; and according to the displacement of each peak in the hexahedron units, interpolating a coordinate of a peak of a triangular mesh in the plant leaf model. According to the method, the voxel set is constructed through the three-dimensional model, on the basis that the mass-spring model constructed by the voxel set is multi-layered, the model is more close to an internal structure of a real plant leaf, and the connection between mass springs is more stable; an implicit Newmark integration algorithm is employed, simulation can be carried out under a large step length, and the model is ensured to carry out real-time visual simulation.