The invention discloses a full duplex scrambling transmission method in an untrusted relay network, which is applied to a wireless communication system including three nodes of an information source, a relay and a destination node, and the relay is an untrusted relay. The method comprises the following steps: in a first time slot, transmitting information to the relay and the destination node by the information source, and receiving information source information by the destination node and transmitting an interference signal to the relay; in a second time slot, amplifying the signal received in the first time slot by the relay by adopting an amplify-and-forward protocol, after that, forwarding the signal to the destination node; performing self-interference cancellation by the destination node according to estimated channel information, and performing maximal-ratio combining on information received in the first time slot and the second time slot; and calculating the instantaneous security capacity of the system according to the received signal to noise of the relay in the first time slot and the received signal to noise of the destination node in the two time slots. The method of the invention can not only make the information source send the information to the destination node efficiently, but also make the destination node effectively interfere with the relay node to receive useful information, so as to maximize the security capacity of the system.