The invention belongs to the technical field of medical
experimental animal models, and discloses a
small animal model for
skull base high-flow
cerebrospinal fluid leakage and
skull base reconstruction as well as a construction method and application of the
small animal model. The technical obstacle that due to the fact that the
nasal cavity of a
small animal is narrow and the turbinate structure is complex, surgical instruments cannot reach the
skull base through the
nose is overcome, meanwhile, a modeling and repairing area is arranged on the rear nasal meatus and the top wall of the nasopharynx, and the temperature and
humidity conditions and environment of the nasal mucosa are reserved; and the microenvironment for
tissue healing after the endoscopic transnasal skull base
surgery is restored on the pathophysiological level. The dissected marking points are clear, and compared with narrow anterior skull base low-flow
cerebrospinal fluid leakage of small animals, the standardized
bone defect constructed in the middle skull base butterfly
saddle area can cause continuous and high-flow
cerebrospinal fluid leakage;
autologous bone flap and free
mucous membrane repair is used, the method is the same as current clinical practice, and a new platform can be provided for screening of skull base repair materials or operation evaluation and retrograde
intracranial infection research after an operation.