144 results about "Sleep apnea syndromes" patented technology

An active medical device have an improved diagnosis of a sleep apnea syndrome. This device measures the respiratory activity of the patient, determines a state of activity, this state being likely to take, according to satisfaction of predetermined criteria, a value representative of a state of sleep of the patient, and analyzes a detected signal corresponding to the respiratory activity to detect, when the aforementioned state is a state of sleep, the presence of respiratory pauses, and thereby to produce an indicating signal of sleep apnea in the event of the occurrence of a respiratory pause of duration longer than a first predetermined duration. The analysis also includes inhibiting the production of the aforesaid indicating signal, or a treatment to resolve an apnea, when the duration of the detected respiratory pause is longer than a second predetermined duration, typically of at least one minute.

A sleep apnea syndrome diagnosing device disclosed herein comprises: a snoring sound collector which collects snoring sound; a snoring sound holder which holds the collected snoring sound; a correlation coefficient calculator which divides a time axis of the snoring sound held in the snoring sound holder into plural cycles and which sequentially calculates a correlation coefficient between the snoring sound of one cycle and the snoring sound of a cycle next to the one cycle; and an output section which outputs the correlation coefficient calculated by the correlation coefficient calculator.

The invention relates to a method for detecting sleep apnea by using electrocardiosignals, which is characterized by comprising the following steps of: 1) detecting QRS by using a slope threshold method, calculating a time sequence during a R-R period, and carrying out partial detection of the time sequence during a R-R period by using least square straight-line to obtain a heart rate variability signal HRV; 2) using the change of the HRV with the heart rate as a random signal and selecting continuous 500 to 800 data points as a sliding window to decompose the HRV signal into intrinsic mode functions IMF; 3) transforming all intrinsic mode functions IMF to obtain an HH spectrum; 4) calculating the average value of the instantaneous frequency of the IMF components and the standard deviation of the instantaneous amplitude of the IMF components according to the HH spectrum; and detecting the time and times of sleep apnea according to the change of a characteristic value. The method is reliable in result and good in real-time and provides a now analytical tool for early diagnosis and ward and prognosis evaluation of sleep apnea syndrome.

The invention discloses a screening system for sleep apnea syndrome in family environment, comprising a snore data obtaining module, a snore processing module and a distinguishing module, wherein the data obtaining module is used for collecting the snore data; the snore signal processing module is used for firstly performing the preprocess of the voice signals such as framing, pre-emphasizing and window adding and then completing the end point detection for the snore by a double-gate detecting method; the first ten frame data of the snore sample is taken as the first measure of the background noise in the process of performing end point detection; and then the data of snore section is transmitted to an energy-ratio solution module. Finally, resolving the features of the energy ratio of the snore section and then transmitting the features of the energy ratio to the distinguishing module. The distinguishing module takes the energy ratio as the categorical data; if the energy ratio of a patient is higher than a certain threshold quantity, then the patient is distinguished as OSAS sufferer; if not, then the patient is the single snorer. The invention provides a system that brings less interference for the sleep of the patient and low cost and can still reach higher screening precision even in family environment.

The invention discloses a sleep apnea syndrome detecting system. The sleep apnea syndrome detecting system is composed of a sleep respiration detecting device, a processing and diagnosing device, a thermistor sensor, positive electrodes and negative electrodes, wherein the sleep respiration detecting device is composed of a protecting circuit, a resistance type respiration detecting module, an electrocardio signal detecting module, an acceleration detecting module, a oral-nasal respiration detecting module, a processor module and a wireless communication module; the thermistor sensor is used for detecting oral-nasal respiratory airflow; the positive electrodes and the negative electrodes are used for detecting body chest breathing and electrocardio signals. Through the sleep apnea syndrome detecting system, a patient does not need to be hospitalized; the sleep apnea syndrome detecting system is simple and avoids physiological and psychological burdens. The sleep apnea syndrome detecting system can comprehensively detect the respiratory status of different parts of a human body to achieve the aim of sleep apnea syndrome classification and diagnosis, and meanwhile is simple in operation and can be used at home.

A method and system for Sleep Apnea Syndrome (SAS) screening are disclosed. The method comprises detecting at least one physiological signal, converting the at least one physiological signal into at least one sensor stream, and processing the at least one sensor stream to perform the SAS screening. The system includes a sensor to detect at least one physiological signal, a processor coupled to the sensor, and a memory device coupled to the processor, wherein the memory device includes an application that, when executed by the processor, causes the processor to convert the at least one physiological signal into at least one sensor stream and to processor the at least one sensor stream to perform the SAS screening.

The invention relates to an intelligent pillow capable of monitoring sleeping information of a user, which includes a pillowcase and an inner container, wherein the inner container is arranged in inner container space formed by the pillowcase; at least one air bag is distributed on the obverse side of the inner container, an air nozzle is arranged on the air bag, and the air nozzle is positioned on the reverse side of the inner container; a sensor is also arranged inside each air bag, and each air bag is close to the surface of the pillowcase; each sensor is also connected with a processor; and each processor is connected with a sound sensor which is used for acquiring sleeping information such as respiratory rates, respiratory frequency and respiratory apnea of a user during sleeping. The intelligent pillow has the advantages as follows: 1, sleeping information such as pressure, aspiration, snore, head distribution and head movement of the user during sleeping can be acquired through the multiple sensors and the multiple sound sensors; and 2, the multiple-air bag design enables the sleeping quality of the user to be detected more accurately, is stable and comfortable, can provide bases for preventing and curing the obstructive sleep apnea syndrome, helps the user change sleeping habits and improves the sleeping quality and the health of the user.

The invention discloses a sleep monitoring obstructive locator based on snore analysis. The sleep monitoring obstructive locator based on the snore analysis comprises a recorder for recording sleep sound of a patient, and a processor for performing intelligent analysis according to the sleep sound; an audio signal output end of the recorder is connected with a voice interface of the processor; the processor comprises a sound acquisition module, a data storage module, a data reading module, a data analyzing module and a reporting module; the data analyzing module calculates and processes the sound data to obtain snore loudness, a snore frequency, a snore index, apnea time, hypopnea time and a sleep breathing disordered index; and the reporting module judges whether a numerical value is in accordance with a standard of a sleep apnea syndrome, determines an upper airway obstructive part according to the numerical value and outputs a determination result. The sleep monitoring obstructive locator can detect sleep breathing disordered degree and the upper airway obstructive part, has no limitation to the patient and is easy to operate.

The present invention relates to a comfortable type removable tongue position corrective anti-snoring & anti-suffocating device. The device is made of wire or band material provided with suitable elasticity and rigidity, including at least a fixer, an upper force piece which is connected with the fixer and lower force piece. The device is mostly applied on upper jaw. The force end of the upper force piece is designed to be suitable to the normal configuration of the soft palate palatine, and acts on the portion in front of the sensitive position of the soft palate to raise up the soft palate palatine and uvula upward / upward and backward suitably without causing nausea and discomfort of peripheral tissue. The force end of the lower force piece is designed to be suitable to the normal configuration of the big tongue, and acts on the portion in front of the sensitive position of the posterior of the tongue to press the big tongue downward / front downward without causing discomfort and nausea. Thus, depending on the co-action of the upper and lower force piece, the blocked respiratory tract could be expanded to prevent snore and remit sleep apnea syndrome.

The invention discloses a sleep apnea syndrome assessment method based on electrocardiogram signals. The method comprises the following steps: acquiring the night electrocardiogram signals; pre-processing the electrocardiogram signals so as to obtain clean electrocardiogram signals; finding out the position of a peak value of R wave by virtue of R wave detecting algorithm, and conducting calculation so as to obtain RR sequences; interpolating the RR sequences, so that the RR sequences are identical in length; and dividing the interpolated RR sequences into three groups in accordance with a sample: a pre-training group, a fine-adjusting group and a test group, wherein by virtue of the pre-training group and the fine-adjusting group, an OSAS (obstructive sleep apnea syndrome) recognition model is constructed and optimized, and by virtue of the test group, an assessment result of the model on the OSAS is obtained. The method provided by the invention, by collecting the human electrocardiogram signals in a noninvasive mode, can be used for assessing the sleep apnea syndrome, and for the RR sequences extracted from original electrocardiogram signals, characteristic learning and OSAS recognition model construction can be conducted by virtue of a sparse self-coding network; meanwhile, network parameters are optimized through micro-adjusting, so that the model is more excellent in recognition capacity and good assessment is conducted; and the method provided by the invention is available by collecting the electrocardiogram signals within 8h at night.

The invention relates to a method for detecting obstructive sleep apnea syndrome. The method includes the following steps: using a photoelectric plethysmography (PPG) sensor for oxygen saturation information collection, using a snore sensor for snore information collection, and using a respiration signal sensor for respiration information collection; processing collected respiration information to acquire an average respiration rate and average respiration strength; processing collected snore information to acquire average snore strength within a time period before current moment; performing high-pass filtering on collected PPG signals; according to an artificial intelligent decision-making theory, building a fuzzy element set by the respiration information, the snore information and the oxygen saturation information after being processes, establishing a subordinate function, creating a fuzzy grade list and a fuzzy function set, building a multi-factor evaluation matrix and judging whether a person has the obstructive sleep apnea syndrome or not according to a maximum subordinate principe. The invention further relates to a system for detecting the obstructive sleep apnea syndrome.

The invention relates to a sleep apnea syndrome detection method based on pulse and blood oxygen signals. The method includes: digging characteristic parameters related to SAS (statistical analysis system) from the pulse and blood oxygen signals by means of probability principal component analysis, setting up an SAS detection characteristic matrix, adopting a pouch decision tree for mapping the relation between the characteristic matrix and SAS disease degrees, and setting up an SAS detection model. By means of probability principal component analysis, input data dimensionality is decreased while quality of the characteristic matrix is improved; owing to the pouch decision tree, SAS detection accuracy is improved; by utilization of the sleep apnea syndrome detection method based on the pulse and blood oxygen signals, the SAS disease degrees of testees can be outputted only by inputting the pulse and blood oxygen signals of the testees.

This relates to a sleep apnea test sensor assembly (20) comprising multiple sensors to be used for diagnosis of sleep apnea syndrome, and a test equipment (30) comprising the same. The respective sensors each associate sensing data measured by a respective sensing section with time data of a clock unit, and store them in a storage unit so as to allow the sensing section to perform sensing at a predetermined period in response to a clocking operation of the clock unit, and set time of the clock unit in response to a synchronous signal input from outside. The respective sensors operate physically independently of each other, but can measure sensing data with the synchronization in time therebetween being secured, enabling accurate diagnosis of SAS.

The invention describes a method for treating Obstructive Sleep Apnea Syndrome (OSAS) utilizing positive airway pressure (PAP) by creating a single-piece, dual arch airway orthotic, using said orthotic to obturate the oral cavity via an acrylic seal between the upper and lower dental arches, retaining the upper and lower dental arches in elastomeric material via a snap-fit and applying PAP via the nasal passages from tubing which is supported from said airway orthotic.

The invention discloses a device for monitoring and managing sleep quality and promoting sleep. The device comprises a hand monitoring unit and a pillow monitoring unit. The hand monitoring unit evaluates the specific sleeping condition of a monitored person and starts a corresponding preset hand perceptual mode by acquiring and analyzing the pulse information, the heart rate information, the motion information, the oxyhemoglobin saturation information, the regular exercise amount and the sleeping posture information of the monitored person, the temperature information of the environment where the monitored person is located, and the brightness information of the sleeping environment. The pillow monitoring unit acquires all the information of the monitored person, and starts a corresponding preset pillow vibration mode. The device has the advantages of being capable of promoting sleep, precise in data, safe, environment-friendly, multifunctional, small, portable and the like. The device can conduct multi-dimensional monitoring on multiple indexes like sleep quality, exercise amount and basal metabolic rate, can dynamically and intelligently conduct individualized guidance and management on sleeping plans according to sleeping parameters acquired through previous multi-dimensional monitoring, and can be applied to the normal sleep population, the insomnia population, the sleep apnea-syndrome population and the population with a snoring history but not diagnosed as sleep apnea-syndrome yet.

A novel pyrazole derivative of the following formula having a histamine H3 receptor antagonistic effect:or a pharmaceutically acceptable salt thereof or a pharmaceutical preparation comprising the same as an active ingredient is effective for prevention or treatment of dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.

It is an object of this invention to provide a medical treatment device for curing snore and sleep palate syndrome, which is small in size, easy to place, allows patients to have communication after placement, does not induce the patients any physical disorder to jaw joint and jaw muscle, simple in operation and structure, and highly effective in physical treatment. There is provided a medical treatment device for curing snore and sleep apnea syndrome, which comprises a fitting body 10 and a guide plate 20. The fitting body 10 is formed in a generally U-shape in plane view and in cross section, and it is fitted to the teeth 3 and the gingiva 5 of the upper jaw 1. The guide plate 20 is extended in the diagonal rear lower side direction from the front portion of the fitting body 10. The guide plate 20 makes a contact with front teeth 4a of a lower jaw 2 at an outer surface 21 thereof, and it forwards the front teeth 4a of the lower jaw 2 to take a forwarding position. The guide plate 20 makes a contact with a tongue 6 at an inner surface thereof for holding the tongue 6 in a forwarding position.

A pacemaker system comprising apnea detecting means for measuring parameters about respiratory including at least two parameters of the number of apneas per unit time and the period of time during which an apnea continues and detecting an apnea state of a sleeping patient on the basis of the measured parameters, characterized in that when the measured values of the detection parameters measured by the apnea detecting means increase over reference values at which the pacing rate is changed to a preset and stored SAS treating pacing rate, the pacing rate is changed and the pacing mode is changed to an SAS treating pacing mode. The apnea syndrome of the sleeping patient is detected and treated coping with the bradycardia and various problems accompanying the apnea syndrome. The pacing rate and the pacing rate time can be set suitably for the patient without imposing too heavy a burden on the patient depending on the condition of the patient, and consequently the syndrome of the SAS can be treated efficiently and reliably.

The invention provides an adjustable mandibular advancement device used for treating benign sleep apnea syndromes, mild-moderate obstructive sleep apnea hypopnea syndromes and sleep apnea syndromes. The adjustable mandibular advancement device comprises an upper tooth socket and a lower tooth socket, a first connecting block is arranged on the lower surface of the upper tooth socket, a second connecting block is arranged on the upper surface of the lower tooth socket, and the first connecting block and the second connecting block are connected through connecting shafts. One end of each connecting shaft is connected with one connecting block through meshed thread structures, and the other end of the same is connected to the other connecting block. By the adjustable mandibular advancement device, accurate mandibular advancement amount is provided according to actual requirements of a user, so that the 'sleep apnea syndromes' is treated more effectively.

Provided are a histamine-H3 receptor antagonist; and a preventive and / or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty liver, circulatory system diseases, for example, stenocardia, acute / congestive cardiac insufficiency, cardiac infarction, coronary arteriosclerosis, hypertension, nephropathy, sleep disorder and various diseases accompanied by sleep disorder such as idiopathic hypersomnia, repetitive hypersomnia, true hypersomnia, narcolepsy, sleep periodic acromotion disorder, sleep apnea syndrome, circadian rhythm disorder, chronic fatigue syndrome, REM sleep disorder, senile insomnia, night worker sleep insanitation, idiopathic insomnia, repetitive insomnia, true insomnia, electrolyte metabolism disorder, and central and peripheral nervous system diseases such as bulimia, emotional disorder, melancholia, anxiety, epilepsy, delirium, dementia, shinzophrenia, attention deficit / hyperactivity disorder, memory disorder, Alzheimer's disease, Parkinson's disease, sleep disorder, recognition disorder, motion disorder, paresthesia, dysosmia, epilepsy, morphine resistance, narcotic dependency, alcoholic dependency. The histamine-H3 receptor antagonist comprises a piperidine derivative compound of formula (I) [wherein X1 and X2 independently represent a nitrogen atom or CH; Y represents a specific group; X3 represents Os—(CH2)m; R1 and R2 independently represent a hydrogen atom, a halogen atom, a linear or branched lower alkyl group, a lower alkoxy group, or an acetyl group substituted with 2 or 3 fluorine atoms; s is 0 or 1; and m is an integer to make (m+s) 0 or from 1 to 4], or its pharmaceutically-acceptable salt.

A device for separating between the upper and lower jaws is disclosed. The device comprises at least one substantially U-shaped rib and a deformable member associated therewith such that said member gradually changes its shape when a pressure is applied on the at least one rib by the jaws. The device is suitable for preventing self-inflicting or externally inflicted injury or for suppressing upper airway resistance syndrome, sleep apnea syndrome or snoring. By filling at least one reservoir formed in the deformable member with a beneficial or edible material and inserting the device into the oral cavity of a subject such that said deformable member separates an upper set of posterior teeth from a corresponding lower set of posterior teeth, the beneficial or edible material may be delivered to the subject.

The invention relates to a composition of Chinese yam polysaccharide and Chinese yam protein and an application thereof. The composition of the Chinese yam polysaccharide and Chinese yam protein comprises natural active substances extracted from Dioscoreaceae Chinese yam and other Dioscoreaceae plants and is yellowish-brown powder. The clinical observation proves that the natural composition of the Chinese yam polysaccharide and Chinese yam protein has good medical application of treating sleep apnea syndrome, and obvious effect.

Small tracheostomy appliances for use in treating Sleep Apnea Syndrome. The appliances are inserted in a tracheotomy incision, low on a patient's neck to equalize intra-tracheal pressure with ambient pressure under certain conditions to prevent undesirable increases in blood CO2 that could otherwise cause arousals from sleep.

This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from obstructive sleep apnea syndrome (OSAS). Treatment of OSAS is effected by administering a carbonic anhydrase inhibitor to the patient in combination with at least one additional active agent. Examples of additional active agents include modafinil, eszopiclone, zolpidem, zaleplon, and phentermine.

Electric stimulation method and system for treating Obstructive Sleep Apnea (OSA) Syndrome using an external actuator on the pharyngeal-laryngeal muscles.Using this actuator, the muscles involved receive an electric stimulus, with the aim of widening the muscular opening and attaining sufficient air flow to prevent the lack of air. Said stimulus only acts in the event of an apnea episode being detected, by means of analyzing sound patterns of the upper airways. Both detection and treatment arc self-regulatory, in order to adapt to the patient's morphology and the evolution of the condition or problem.

The invention discloses a total effective part extractive of morinda officinalis, a preparation method and application thereof in medicaments for treating snoring, and the total effective part comprises the following components in percentage by weight: 50-90 percent of morinda officinalis total polysaccharide, 2-5 percent of morinda officinalis total anthraquinone, 5-30 percent of morinda officinalis total iridoids and the like. The preparation method comprises the following steps of: drying the morinda officinalis, and crushing into 10-100 meshes; heating with water for reflux extraction; processing the extract by using a weak base anion exchange resin column, collecting the cross-flow liquid and water eluent, and condensing and drying to obtain the total polysaccharide; carrying out reflux extraction on the dregs of decoction with petroleum ether or 6# extraction solvent oil or other organic solvents with polarity similar to that of the dregs, and removing low-polarity components, such as essential oil and the like; heating the residual dregs with ethanol water with a certain concentration for reflux extraction, and condensing the extract to prepare the total anthraquinone and total iridoids; and then merging the three components, and drying to obtain the total effective part extractive of morinda officinalis. The product of the invention is used for treating snoring (also called as Sleep apnea syndrome (SAS)), and has the advantages of quick and remarkable curative effect, no toxic or side effect, low price, convenient use and the like.

The present invention is directed to a method of treating a subject for a pulmonary disease by administering a therapeutically effective amount of a compound of the formula:wherein R1, R2 or R3 are each independently a C1 to C6 alkyl, a halogen, a sulfate, or a phosphate. The pulmonary disease in the subject can be hypoxic pulmonary vasoconstriction, pulmonary edema, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, cystic fibrosis, interstitial fibrosis, high altitude residence, sleep apnea syndrome, atrial septal defects, and pulmonary diseases associated with other conditions. If this same compound is modified so that R1, R2 or R3 each independently is a C1 to C6 alkyl and the compound is not a carbonic acid inhibitor, it can be administered to a subject to block hypoxic pulmonary vasoconstriction and / or prevent high altitude pulmonary edema. Additional aspects of the present invention include an inhalable composition comprising the compound of the above formula without modification and an inhalable carrier, as well as the above modified compound.

The invention discloses a portable wireless snore monitoring system. The system comprises an upper computer and a lower computer which are in wireless communication; the lower computer comprises a collecting device and is used for collecting snore data; the upper computer comprises a data analysis device and is used for obtaining the snore data in a wireless communication mode and analyzing a snore signal to obtain the maximum snoring amplitude, and the maximum snoring frequency per 30 min, amplitude distribution, the total number of snoring, the number of snoring per hour and parameters of the number of meeting a sleep apnea syndrome and can judge severity of snoring and whether a lesion occurs or not. According to the technical scheme, the portable wireless snore monitoring system has the advantages of being low in cost, easy to operate, easy to use, friendly to human and machine and suitable for measurement in an environment of sleeping at home.

The invention discloses an intelligent system for monitoring and stimulating the sleep apnea syndrome. The intelligent system comprises a monitoring and analyzing assembly and a stimulating and intervening assembly, wherein the monitoring and analyzing assembly comprises a coat carrier, at least one sensor used for detecting human sleep breath feature signals in real time and a first data acquisition and processing module are arranged on the coat carrier, the at least one sensor is electrically connected with the first data acquisition and processing module, and the first data acquisition and processing module can perform acquisition and analysis judgment treatment on the human sleep breath feature signals detected by the at least one sensor; the stimulating and intervening assembly comprises a wrist strap body, a control module and an electrode are arranged on the wrist strap body, the control module is wirelessly connected with the first data acquisition and processing module, and the electrode is electrically connected with the control module and can be driven by the control module to stimulate a human body. The whole operation process of the intelligent system is simple and reliable, and the intelligent system can effectively monitor the human sleep state.