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33 results about "Staphylococcus salivarius" patented technology

Streptococcus salivarius is a species of spherical, gram-positive, facultative anaerobic bacteria that is both catalase and oxidase negative. S. salivarius colonizes (usually in chains) the oral cavity and upper respiratory tract of humans just a few hours after birth, making further exposure to the bacteria harmless in most circumstances.

Oral probiotic composition

The invention relates to an oral probiotic composition, which contains Streptococcus salivarius K12, and one or more of the Chinese herb extract effective ingredients eugenol, tea polyphenol, glycyrrhizic acid, menthol, radix scrophulariae total glycoside, hericium erinaceus polysaccharide, Pachymaran, a dark plum water extract, and pueraria isoflavone. The composition can adjust oral flora balance, clean the oral cavity and improve oral air, and also has the efficacy of diminishing inflammation and relieving sore swollen throat.
Owner:NANJING CANCHEN MICROBIAL TECH

Antimicrobial composition

This invention provides novel Streptococcus salivarius, compositions containing same, and use of S. salivarius strains as antimicrobial agents. The strains are bacterial inhibitors with respect to at least S. mutans and / or MS and therefore have a number of therapeutic applications. The applications include but are not limited to forming part of therapeutic formulations for use in controlling, treating, or preventing dental caries.
Owner:BLIS TECHNOLOGIES LTD

Pharmaceutical composition and food for preventing or treating oral diseases

The invention discloses a pharmaceutical composition and food for preventing or treating oral diseases. Both the composition and food comprise lactobacillus paracasei L9 and staphylococcus salivariusLD11. Studies show that the L9 and the LD11 can significantly alleviate the occurrence degree of E-level dental caries of an occlusal surface, after the composition and food containing the L9 and LD11are taken, the structures of oral floras change significantly, especially actinomycetes are significantly increased, and klebsiella, aerococcus, Gemella, corynebacterium and pseudomonas aeruginosa are significantly reduced in the category classification level. Taking of the L9 and LD11 can significantly reduce saliva species richness, the relative abundances of bacteria related to the oral diseases such as staphylococcus salivarius, actinomycetaceae and peptostreptococcus are significantly reduced, and periodontitis diseases may be alleviated; the species diversity of a dental plaque flora issignificantly reduced, the relative abundances of leptotrichia, fusobacterium and flavobacterium are all significantly reduced, and the oral diseases such as periodontal diseases, ozostomia and dental caries may be alleviated.
Owner:BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY

Streptococcus salivarius and application thereof in preparing ozostomia eliminating drug

The invention provides an oral probiotics strain, the preservation number of which is CGMCC NO.12899, the preservation data of which is August 23, 2016, the preservation class of which is named as Streptococcus Salivarius, and the preservation unit of which is CGMCC with the address of Institute of Microbiology, CAS, #3, Yard #1, West Beichen Road, Chaoyang District, Beijing. The strain can obviously inhibit generation of volatile sulfide compounds of an ozostomia standard strain with clostridia. The invention also discloses an application of the strain in preparing the ozostomia eliminating drug, and the strain has wide application prospect and value in eliminating ozostomia and preparing a microecological preparation for establishing a beneficial oral microecological environmental effect.
Owner:ICDC CHINA CDC

Intestinal microorganism markers for multiple myeloma, application and detection preparation of intestinal microorganism markers

ActiveCN110669818AAccurately reflect clinical diagnosisAccurately reflect treatment effect assessmentMicrobiological testing/measurementMicroorganism based processesDiseaseKlebsiella variicola
The invention discloses intestinal microorganism markers for detecting multiple myeloma diseases, and an application and detection preparation of the intestinal microorganism markers. The intestinal microorganism markers comprise citrobacter freundii, enterobacter cloacae, raoultella ornithinolytica, klebsiella aerogenes, klebsiella variicola, klebsiella pneumoniae, streptococcus salivarius, streptococcus oralis, streptococcus gordonii, streptococcus mitis, streptococcus pneumoniae, butyrate producing bacteria, clostridium butyricum and clostridium saccharobutylicum. The intestinal microbial markers can be used alone or in combination. The invention discloses a support vector machine (SVM) classification model constructed by taking the microbial markers as characteristics, and the SVM classification model is applied to clinical diagnosis of multiple myeloma diseases. The invention also discloses an application of the microorganism markers in preparation of a diagnostic preparation formultiple myeloma diseases.
Owner:CENT SOUTH UNIV

Kit for detecting colorectal cancer indicator bacteria

The invention discloses a kit for detecting colorectal cancer indicator bacteria. The kit is characterized by comprising the following components: a specific primer combination for identifying the indicator bacteria, wherein the primer combination is shown as SEQ ID NO. 1-14, and the indicator bacteria are the combination of fusobacterium nucleatum (F.nucleolus), anaerobic digestion streptococcus(P.anaerobicus), clostridium symbiosum (C.symbiolum), Porphyromonas saccharolytica (P.asaccharolytica), Prevotella intermedia (P.intermedia), Bacteroides fragilis (B.fragilis) and Streptococcus salivarius (S.salivarius). The kit for detecting colorectal cancer indicator bacteria disclosed by the invention has the beneficial effects that the colorectal cancer can be identified only by collecting astool sample. The principle is that the aim of identifying the colorectal cancer by detecting the colorectal cancer pathogenic bacteria in excrement, the sensitivity can reach 92.9%, and the specificity is 92.6%.
Owner:SHANGHAI PASSION BIOTECHNOLOGY CO LTD

Probiotic solid beverage facilitating oral health

The invention belongs to the technical field of probiotic products and relates to a probiotic solid beverage facilitating oral health. The solid beverage comprises the following ingredients by mass percentage: 20-30wt% of lemon extract, 10-20wt% of inulin, 15-20wt% of streptococcus salivarius, 15-20wt% of lactobacillus salivarius and 15-20wt% of lactobacillus acidophilus. Three probiotics adoptedby the beverage can protect the oral health and prevent oral diseases by inhibiting growth and reproduction of pathogens and competing adhesion sites on the surface of an oral mucosa with the pathogens; the inulin can improve a flavor of the product, promote propagation of the probiotics and absorb water from the product; the probiotics are higher in stress resistance and higher in survival rate,so that the product has a longer shelf life; and the lemon extract is fresh in smell, allows the solid beverage to have a unique flavor, can quickly dissipate an oral peculiar smell, is rich in vitamin B and vitamin C, can prevent gum bleeding and dental ulcers and makes gingivae strong.
Owner:THANKCOME BIOLOGICAL SCI & TECH CO LTD

Composition, its application and oral preparation with effect of improving oral health

The invention discloses a composition, application thereof and an oral preparation capable of improving the oral health. According to the composition, by adding 1-20 parts of lactobacillus rhamnosus R11, 1-20 parts of streptococcus salivarius blis K12 and 1-20 parts of lactobacillus reuteri HA188 (in parts by weight), the effect of probiotics on the improvement of the oral health is obviously improved; by further adding one or more of lactobacillus helveticus Lafti L10, saccharomyces cerevisiae boulardii, folic acid compounds, coenzyme Q10, vitamin C, fructo-oligose, xylooligosaccharide and galactooligosaccharide, the effect of the composition on the improvement of the oral health can be further improved; and an unexpected discovery shows that by adjusting the addition weight ratio of streptococcus salivarius blis K12 to lactobacillus reuteri HA188, the light degradation rate of the folic acid compounds in the composition can be remarkably decreased. The composition prepared by virtueof an equivalent gradient premixing method can be used for preparing the oral preparation capable of improving the oral health.
Owner:北京斯利安药业有限公司

Probiotic microecological preparation for treating oral halitosis and inflammation as well as preparation method and application of probiotic microecological preparation

The invention relates to the technical field of microbial preparations, in particular to a probiotic microecological preparation for treating oral halitosis and inflammation as well as a preparation method and application thereof. The probiotic microecological preparation comprises the following raw materials in parts by weight: 5-80 parts of probiotics, 1-40 parts of a functional sweetening agent, 1-20 parts of maltodextrin and 2-10 parts of freeze-dried fruit powder, wherein. the probiotics comprise streptococcus salivarius k12. All the component substances are compounded to generate a synergistic effect, so that various nutrients are provided for consumers, the probiotic effects of better protecting oral cavity health care and the like are achieved, and an important effect is achieved on prevention of oral diseases such as periodontitis, decayed teeth, halitosis and oral ulcer.
Owner:富益元(东莞)生物科技有限公司

Saliva streptococcus 57.I urase gene and its urase

This invention relates to a urase gene of streptococcus salivarius, concretely, concerning about a 57.I urase gene of streptococcus salivarius and its urase. A 57.I urase gene of streptococcus salivarius , whose nucleotide sequence is what is described in SEQ ID NO.1. Nickel ion bonding in the gene and nucleotide sequence of transit-related gene MQO are what are described in SEQ ID NO.2. The advantage of this invention is that gaining the cloning of urase gene of streptococcus salivarius U35248 by the method of segment cloning and gradually enzyme-cutting connection ,and its object gene length proceeds to 8Kb, increasing Nickel ion bonding of the gene and transit-related gene MQO compared with existing technology , therefore, expressing ureolytic activity without adding exogenous NiCl2.Attained cloning can be used for future replacement therapy in anti-caries research building without adding exogenous NiCl2,more suitable for clinical application of production alkali effect germ.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Streptococcus salivarius and application thereof to preparation of medicines for treatment of inflammatory bowel diseases

InactiveCN110452860AImprove intestinal inflammationAvoid damageBacteriaAntipyreticFecesScreening method
The invention provides streptococcus salivarius and an application thereof to preparation of medicines for treatment of inflammatory bowel diseases, and relates to the field of a biological technology. The streptococcus salivarius (streptococcus salivarius) 1802 is preserved in the preservation center with the preservation number of CCTCC NO:M 2019251. A screening method of the streptococcus salivarius comprises the steps of enabling excrement of healthy people to be subjected to suspension with bacteria-free water, performing diluting until the volume is 10-6 times, and performing fractionalcultivation in a brain-heart leaching solution culture medium with a plate streak to obtain the streptococcus salivarius (streptococcus salivarius) 1802. The streptococcus salivarius (streptococcus salivarius) 1802 can be applied to preparation of medicines for treatment of inflammatory bowel diseases, can be used in medicines for relieving inflammatory reactions of the inflammatory bowel diseases, and can be applied to medicines for relieving inflammatory bowel disease colon mucous membrane injury.
Owner:XIAMEN UNIV

Preparation method for triclosan-containing poly(beta-urethane-urea) and application of triclosan-containing poly(beta-urethane-urea) in selectively killing oral streptococcus mutans of biofilm

The invention discloses a preparation method for a triclosan-containing polyethylene glycol-b-poly(beta-urethane-urea) polymer micelle and application of the micelle in selectively killing an oral streptococcus mutans of a biofilm. The polyethylene glycol-b-poly(beta-urethane-urea) polymer is obtained by performing Michael addition reaction on triclosan-containing monomer molecues. The triclosan-bonded polyethylene glycol-b-poly(beta-urethane-urea) polymer has relatively good killing effect on the harmful bacteria oral streptococcus mutans of the biofilm, and can selectively keep oral beneficial bacterium streptococcus salivarius. The micelle system has the advantages that: firstly, preparation is simple; secondly, large-scale preparation can be realized, and conversion to the clinical direction is easy; thirdly, biofilm infiltration capacity is good; and fourthly, selective killing ability on harmful bacteria is achieved.
Owner:NANKAI UNIV

Application of Streptococcus salivarius k12 in the preparation of medicaments for preventing and/or treating autoimmune diseases

The invention provides an application of streptococcus salivarius K12 in preparing a medicament for preventing and / or treating autoimmune diseases, and belongs to the technical field of treatment of autoimmune diseases. Preventive intervention of the streptococcus salivarius K12 can inhibit occurrence and development of experimental arthritis, so that the incidence of the experimental arthritis isreduced by 30-70% and the synovial tissue of a joint can be prevented from infiltration and erosion of inflammatory cells; in addition, streptococcus salivarius also has therapeutic effects on the experimental arthritis. The streptococcus salivarius K12 can significantly down-regulate the ratio of Tfh cells, GCB cells, DC cells and Neu cells, inhibit the expression of proinflammatory cytokine IL-6, and promote the secretion of anti-inflammatory cytokine IL-10. The streptococcus salivarius can promote the immune steady-state reconstruction by inhibiting the immune response and provides a potential target for the treatment of rheumatoid arthritis; can target and regulate abnormal immune cells, treat diseases from an upstream way, and regulate immune balance.
Owner:PEOPLES HOSPITAL PEKING UNIV

Fermented feed for laying hens as well as preparation method and application thereof

The invention discloses a fermented feed for laying hens as well as a preparation method and application of the fermented feed. The preparation method comprises the following steps: sequentially carrying out hydrogen peroxide oxidation and ammonia water pH adjustment on corn steep liquor, uniformly mixing the corn steep liquor with corn bran and wheat bran subjected to steam conditioning treatmentto obtain a raw material mixture, inoculating Baillard yeast and bacillus subtilis, performing aerobic fermentation, then inoculating streptococcus salivarius, performing anaerobic fermentation, andfinally, performing pneumatic drying to obtain the fermented feed. According to the preparation method of the fermented feed for the laying hens, hydrogen peroxide is adopted to treat the corn steep liquor, and sulfite in the corn steep liquor is oxidized, so that adverse effects on animal physiology are eliminated; the corn steep liquor is treated by adopting hydrogen peroxide and ammonia water,and the wheat bran after conditioning treatment with high-temperature steam is combined for use, so that the raw material mixture can be suitable for solid aerobic fermentation of Baillard yeast and bacillus subtilis; and a finished product obtained through combined fermentation of aerobic fermentation and anaerobic fermentation is a good laying hen feed raw material, so that the additional valueof corn starch byproducts is greatly improved, and obvious economic benefits and ecological benefits are realized.
Owner:CHINA AGRI UNIV

A fermented crude extract of Streptococcus salivarius and its preparation method and application

The invention provides a fermented crude extract of Streptococcus salivarius and its preparation method and application. The preparation method comprises the following steps: (1) inoculating Streptococcus salivarius CGMCC NO.13308 in M17 medium containing sucrose for fermentation , to obtain a fermented liquid, the gained fermented liquid is centrifuged to get the supernatant; (2) add ammonium sulfate to the supernatant obtained in step (1), and centrifugally collect the precipitate that separates out when the saturation of ammonium sulfate is 40~80%, and the The resulting precipitate was dissolved, dialyzed, and freeze-dried. The present invention adopts Streptococcus salivarius CGMCC NO.13308 strain for the first time to obtain fermented crude extract, the fermented crude extract of Streptococcus salivarius has inhibitory effect on Streptococcus mutans biofilm formation, discloses that Streptococcus salivarius CGMCC NO.13308 has fermentation The new use of generating inhibitors of Streptococcus mutans biofilm formation broadens the source of inhibitors of Streptococcus mutans biofilm formation.
Owner:BRIGHT DAIRY & FOOD CO LTD

Acute coronary syndrome risk assessment marker for stable coronary heart disease and application

The invention discloses an acute coronary syndrome risk assessment marker for a stable coronary heart disease and application. The markers comprise intestinal flora bifidobacterium longum, streptococcus angora, companion faecalis, Kolinella aerogenes, faecalis przewalskii, bacteroides ovale, anaerocanoidea, bacteroides fragilis, bacteroides holdmann, eubacterium rectum and streptococcus salivarius. According to the invention, risk assessment prediction is carried out on the acute coronary syndrome of the stable coronary heart disease, and the prediction accuracy can be improved.
Owner:FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE

Enzymatic preparation method of glucosamine

The invention relates to an enzymatic preparation method of glucosamine, and belongs to the technical field of bioengineering. The method comprises the following steps: converting D-glucose into D-fructose by adopting glucose isomerase catalysis; and converting D-fructose into glucosamine using transaminase, an amino donor compound and a weak oxidant compound, wherein the glucose isomerase is derived from bacillus coagulans, flavobacterium dendrimer, streptomyces olivaceus, bacillus coagulans, flavobacterium dendrimer and streptomyces olivaceus; and the transaminase is derived from bacillus subtilis, bacillus velezensis, bacillus pumilus, bacillus licheniformis, streptococcus salivarius and lactobacillus masi. According to the method for preparing the glucosamine by catalyzing the D-glucose in vitro by utilizing the biological enzyme, the initial raw materials are glucose isomerase and transaminase required by the D-glucose or D-fructose, and the final product glucosamine can be directly obtained by constructing escherichia coli genetic engineering expression bacteria and catalyzing by adopting a 'one-pot method'. The method has the advantages of cheap raw materials, low production cost, environmental friendliness and the like.
Owner:JIANGSU AOXIN BIOTECHNOLOGY CO LTD

Milk-derived streptococcus salivarius for predicting infant obesity and separation method of milk-derived streptococcus salivarius

The invention provides milk-derived streptococcus salivarius for predicting infant obesity and a separation method of the milk-derived streptococcus salivarius. The milk-derived streptococcus salivarius is a streptococcus salivarius strain SHDP5A1, a 16SrRNA gene sequence of the milk-derived streptococcus salivarius strain is shown as SEQ ID NO: 1, the milk-derived streptococcus salivarius strain is classified and named as Streptococcus salivarius, the preservation number is CCTCCNO:M2021060, the preservation date is January 14, 2021, the preservation unit is China Center for Type Culture Collection, and the preservation unit address is Wuhan University, Wuhan, China. The milk-derived streptococcus salivarius for predicting the infant obesity, provided by the invention, serves as facultative anaerobic bacteria, is easy to colonize in intestinal tracts, and creates conditions for maturation and stabilization of intestinal flora in a later period, so that prediction of filial generation obesity can be realized through abundance detection of streptococcus salivarius in an early life period.
Owner:SHANGHAI TENTH PEOPLES HOSPITAL

Probiotic for the treatment of psoriasis

The use of orally administrable compositions comprising Streptococcus salivarius is described, for the prevention or the treatment of psoriasis in all its forms. In particular, the present invention relates to the use of compositions comprising Streptococcus salivarius, for the treatment of psoriasis in all its forms.
Owner:DI GIROLAMO STEFANO +2

Primer group for detecting streptococcus salivarius, detection system and applications of primer group and detection system

The invention provides a primer group for detecting streptococcus salivarius, a detection system and applications of the primer group and the detection system. The primer group is a specific primer designed for 16S rRNA (ribosomal ribonucleic acid) of intestinal bacteria, and the specific primer comprises 3-5 random bases. The detection system is explored and verified based on the primer group; steps and conditions are mutually matched to achieve synergic enhancement; a detection result of the detection system is stable and accurate; the detection steps are concise and efficient; and wide application prospects and large market values are achieved.
Owner:SUZHOU PRECISION BIOTECH CO LTD

Tableted candy for relieving throat and oral cavity discomfort and preparation method of tableted candy

PendingCN113273631AImprove freshnessDry cough/cough improvementConfectionerySweetmeatsSodium bicarbonateSucrose
The invention discloses a tableted candy for relieving throat and oral cavity discomfort and a preparation method of the tableted candy. The tableted candy capable of relieving throat and oral cavity discomfort comprises the following components in parts by weight: 155 to 165 parts of citric acid, 154 to 165 parts of sodium bicarbonate, 87 to 100 parts of lactic acid bacteria composite powder, 100 to 120 parts of sorbitol, 50 to 69.7 parts of lemon fruit powder, 40 to 60 parts of isomaltitol, 40 to 60 parts of edible spice, 8 to 25 parts of lactobacillus crispatus, 8 to 20 parts of lactobacillus crispatus, 15 to 22 parts of streptococcus salivarius, 8 to 15 parts of magnesium stearate, 10 to 15 parts of resistant dextrin, 8 to 15 parts of mogroside, 0.5 to 2 parts of a champignon extract, 1 to 1.6 parts of menthol, 0.8 to 1.3 parts of sucralose and 0.8 to 1.6 parts of vitamins. The tableted candy has the effects of effectively relieving ozostomia, periodontitis, parched mouth and scorched tongue and dry cough / cough and preventing and relieving acute throat tonsillitis.
Owner:橡果美健实业投资股份有限公司

Streptococcus salivarius and its application in the preparation of drugs for removing halitosis

The invention provides an oral probiotic strain, the preservation number of which is CGMCC NO.12899, the preservation date is August 23, 2016, the preservation classification is named Streptococcus salivarius (Streptococcus Salivarius), and the preservation unit is China Microbiology The General Microbiology Center of the Culture Collection Management Committee is located at the Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The bacterial strain can obviously inhibit the production of volatile sulfide of the bad breath standard strain Clostridium nucleatum. The invention also discloses the application of the above bacterial strains in the preparation of medicines for removing halitosis, which has broad application prospects and value in the preparation of microecological preparations for removing halitosis and constructing beneficial oral microecological environment effects.
Owner:ICDC CHINA CDC

Probiotic composition suitable for oral cavity

The invention provides a probiotic composition suitable for oral cavity, and relates to the technical field of oral cavity health care. The probiotic composition suitable for the oral cavity is prepared from the following raw materials in parts by mass: 10 to 30 parts of microcapsules, 60 to 70 parts of probiotic powder, 10 to 40 parts of plant powder, 5 to 10 parts of isomaltooligosacharide, 5 to 15 parts of fructo-oligosaccharide and 20 to 30 parts of starch, the probiotic powder comprises the following raw materials in parts by weight: 1-10 parts of lactococcus lactis, 1-5 parts of streptococcus salivarius, 1-5 parts of bifidobacterium, 1-10 parts of lactobacillus casei, 1-10 parts of lactobacillus plantarum, 1-10 parts of lactobacillus acidophilus, 1-5 parts of streptococcus thermophilus, 2-5 parts of chitosan, 2-5 parts of lactic acid and 2-15 parts of honey. The probiotic composition is placed in the oral cavity, the probiotic powder and the plant powder can be released to play a role by chewing the probiotic composition, and the taste of the plant powder can be neutralized through the fructo-oligosaccharide, so that the probiotic composition is rich in taste, sweet in taste and convenient to use for many times at high frequency in daily life, and the treatment effect on oral problems is improved.
Owner:河北源民生物科技有限公司

Probiotics-containing care lotion for external use

The invention belongs to the technical field of microorganisms, and discloses a probiotics-containing care lotion for external use. The probiotics-containing care lotion for external use is prepared by mixed fermentation of Streptococcus salivarius, Lactobacillus acidophilus and Lactobacillus rhamnosus. The care lotion for external use is a pure microecological preparation, has a good antibacterial effect but has no side effects.
Owner:杨丽华
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