66 results about "Staphylococcus salivarius" patented technology

The invention belongs to the technical field of microorganisms, and provides streptococcus salivarius subsp. Thermophilus HX-ST36, and the preservation number of the streptococcus salivarius subsp. Thermophilus HX-ST36 is CGMCC NO.32955. The streptococcus salivarius subsp. Thermophilus provided by the invention can be used for fermenting astragalus membranaceus-angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrheal model mouse, a fermentation product can remarkably inhibit the writhing reaction, and the effects of relieving dysmenorrheal and enriching blood can be achieved by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the content of hemoglobin (HGB). The dampness clearing effect of the fermentation product is verified by improving the heavy physical sign of moisture through crowd experiments. The invention also provides a preparation method of the probiotic preparation and the probiotic fermentation product. The preparation methods of the probiotic preparation and the probiotic fermentation product are simple, and large-scale production can be realized.

The invention discloses an intestinal flora marker related to juvenile depression, a product and application of the intestinal flora marker. The intestinal flora marker is prepared from any one or more of prokaryotic streptococcus parahaemolyticus, streptococcus salivarius, Alistipep and Lacnospiraceae, and the intestinal flora marker is prepared from any one or more of prokaryotic streptococcus parahaemolyticus, streptococcus salivarius, Alistipep and Lacnospiraceae, and the intestinal flora marker is prepared from any one or more of the prokaryotic streptococcus parahaemolyticus, the streptococcus salivarius, the Alistipep and the Lacnospiraceae, the prokaryotic streptococcus parahaemolyticus, the Streptococcus salivarius, the Alistipep and the Lacnospiraceae. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal flora marker. The invention provides a product for diagnosing juvenile depression and a computer program product related to the juvenile depression. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of depression of teenagers, and provides a new tool for clinical diagnosis.

The invention discloses a preparation method of high-stability beta-glucan yoghourt. Mixing the sterilized fresh milk with a composite strain consisting of lactobacillus delbrueckii subsp. Bulgaricus, streptococcus salivarius subsp. Thermophilus, bifidobacterium animalis subsp. Lactis, plant lactobacillus, bifidobacterium breve, lactobacillus paracasei, lactobacillus helveticus, lactobacillus rhamnosus and bifidobacterium longum subsp. Longum, and fermenting; and adding beta-glucan into the fermented yoghourt to obtain the high-stability beta-glucan yoghourt. Before beta-glucan is added, the compound bacterial strain is added into the milk, protein in the milk can be gathered under the action of the compound bacterial strain to form a three-dimensional curd network, so that the flowability of a system is reduced, then glucan is added, and the glucan can be uniformly dispersed in curd gaps, so that the glucan is prevented from being excessively combined with the protein in the milk; the stability of a yoghourt system is improved.

The invention relates to the technical field of microorganisms, in particular to space breeding combined lactobacillus salivarius ZK-88-S and application thereof. The combined lactobacillus salivarius ZK-88-S disclosed by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 24, 2024, and the preservation number is CGMCC No.33181; the combined lactobacillus salivarius ZK-88-S can inhibit escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, fusobacterium nucleatum, porphyromonas gingivalis, streptococcus mutans, streptococcus salivarius, streptococcus gordoni or actinomyces naessii, and can be applied to preparation of medicines, daily necessities or health-care foods for oral treatment and oral cleaning.

The invention discloses a meningioma enteric microbial marker, a product and application of the meningioma enteric microbial marker, and belongs to the field of biological medicine. The invention relates to an enteric microbial marker, which is characterized by being prepared from one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and is characterized in that the enteric microbial marker comprises one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and the enteric microbial marker comprises one or more of parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal microbial marker. The invention provides a product for diagnosing meningioma and a computer program product related to meningioma. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of meningioma, and provides a new tool for clinical diagnosis.

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

Provided are Streptococcus salivarius and compositions comprising Streptococcus salivarius for the treatment of ENT diseases, in particular cancer therapy-induced oral mucositis and respiratory tract infections associated with cancer therapy.

The present invention relates to a bacterial strain of Streptococcus salivarius with oral probiotic properties and a minimum inhibitory concentration of at least 500 ppm.

This invention belongs to the field of fermentation inoculant screening and preparation technology, specifically relating to a method for screening strain combinations for preparing mozzarella cheese, the strain combinations themselves, and their applications. The method of this invention systematically evaluates the fermentation kinetics, texture-forming ability, and flavor characteristics of *Streptococcus salivarius* subspecies *thermophilic*, establishing a dynamic ratio screening method to optimize the strain ratio of *Streptococcus salivarius* subspecies *thermophilic*, thereby improving the product quality and batch stability of mozzarella cheese. This method is particularly suitable for solving textural defects or flavor imbalances caused by improper strain ratios in industrial production, providing technical support for the production of highly consistent mozzarella cheese, and can be widely applied in the processing of cheese products, pizzas, and other frozen foods.

The invention belongs to the technical field of health-care products, and particularly relates to a probiotic composition for improving health of an oral cavity and an upper respiratory tract and a preparation method of the probiotic composition. Oral health is an important component of whole body health. Bacterial infections in the oral cavity, such as caries and periodontal diseases, not only influence the oral cavity, but also possibly harm the whole body health and influence the quality of life. The oral cavity is a portal of the respiratory tract, and bad oral hygiene may cause the accumulation of tartar, plaque, soft dirt and the like in the oral cavity and becomes a repository of pathogenic bacteria of the respiratory tract. When the immunity is low, the bacteria may enter the lung through the respiratory tract to cause respiratory tract and even lung infection. The invention discloses a probiotic composition for improving health of oral cavity and upper respiratory tract, which has the effects of resisting inflammation, resisting infection, preventing decayed teeth, protecting oral mucosa, preventing and treating bad breath and the like through the synergistic effect of streptococcus salivarius subsp. Thermophilus K12, lactobacillus rhamnosus CRL1505, lactobacillus salivarius NHNK612, lactobacillus mucus NHNK606 and the like.

The present invention provides an FPR2 agonist. Specifically, the FPR2 agonist comprises, as an active ingredient, outer membrane vesicles derived from at least one lactic acid bacterium selected from the group consisting of genus Lactobacillus, genus Lacticaseibacillus, genus Lactiplantibacillus, genus Ligilactobacillus, genus Lactococcus, and Streptococcus salivarius subsp. thermophilus.

Disclosed are a novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain, a composition containing the same for prevention or alleviation of an oral disease, and oral probiotics, and specifically, the novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain can prevent, treat, and alleviate periodontal diseases through strong antibacterial and antiinflammatory activities against periodontal disease-causing strains, prevents, treat, and alleviates dental caries through strong antibacterial activity against dental caries-causing strains and biofilm formation inhibitory ability, and suppress halitosis caused by oral diseases, thereby contributing to oral health improvement.

The present invention relates to a newly isolated bacterial strain of the species Streptococcus salivarius (S. salivarius). More specifically, the S. salivarius strain was deposited at the BCCM under accession number LMG P-31813. Furthermore, the present invention relates to a composition comprising the isolated bacterial strain of the species S. salivarius. In another aspect, the present invention further relates to the isolated bacterial strain of the present invention or the composition of the present invention for use in immunomodulation and / or treatment and / or prevention of infection or disease.

The application discloses a kind of adolescent autism intestinal microorganism marker and application thereof, belong to the field of biological medicine.The microorganism marker includes one or more of Ruminococcus gnavus, Streptococcus thermophilus, Streptococcus salivarius, Butte's intestinal bacillus, pet big anaerobic clavulanic acid bacteria and Prevotella pittmanniae.The application provides a kind of product (such as kit), including detection reagent for detecting the relative abundance of the microorganism marker.The product provided by the application has good feasibility and accuracy, and can effectively evaluate whether adolescent has the risk of autism, provides a new tool for clinical diagnosis.

The invention belongs to the field of microorganisms, and particularly relates to lactobacillus paracasei with multi-matrix fermentation capacity and application of the lactobacillus paracasei. The lactobacillus paracasei is lactobacillus paracasei Shannan.LPA-972, and the preservation number of the lactobacillus paracasei Shannan.LPA-972 is CCTCC (China Center For Type Culture Collection) NO: M 20242026. The lactobacillus paracasei is lactobacillus paracasei Shannan.LPA-972. The lactobacillus paracasei is related to a phosphoenolpyruvate-glycotransferase system carried by the lactobacillus paracasei. When the fermentation agent containing lactobacillus paracasei, lactobacillus delbrueckii subsp. Lactis and streptococcus thermophilus subsp. Salivarius with a specific viable count ratio is used for fermenting plant milk and animal milk, broad-spectrum adaptability of animal milk raw materials and plant milk raw materials is achieved, meanwhile, the nutrition and sensory quality of fermentation products are remarkably improved, the problem of multi-matrix fermentation can be effectively solved, and the production cost is reduced. And the process cost and complexity of a dairy product production end are effectively reduced.

The invention provides a streptococcus salivarius subsp. Thermophilus for producing phytosphingosine, a preparation method and application, the strain is streptococcus salivarius subsp. Thermophilus, the strain is preserved in the Guangdong Microbial Culture Collection Center on March 10, 2025, the preservation number is GDMCC 65992, and the preservation address is the 5th floor, No. 59 building, No. 100 Courtyard, Xianlie Middle Road, Guangzhou City, Guangdong City. The streptococcus salivarius subsp. Thermophilus has the advantage that the content of phytosphingosine in dairy products can be effectively increased.

The application discloses a Streptococcus salivarius CCFM1512 which can inhibit excessive inflammatory response and relieve periodontitis, and belongs to the technical field of microorganisms. The fermentation supernatant of the Streptococcus salivarius provided by the application can relieve inflammation of human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide in vitro, and can significantly reduce the expression of inflammatory factors such as IL-1beta, IL-6 and IL-17A in gingival tissues, regulate the M1 / M2 polarization balance of macrophages and restore the expression level of DEL-1, so as to relieve alveolar bone absorption of rats. The Streptococcus salivarius has a great application prospect in the aspects of regulating oral inflammatory response and preparing products for relieving periodontitis.

The invention relates to the technical field of fermented dairy products, and discloses a fermented animal and plant double-protein aerated mousse and a preparation method thereof, and the aerated mousse is prepared from the following raw materials by weight: 300-700 parts of animal milk; 100 to 500 parts of plant milk; 40 to 100 parts of a sweetening agent; 100 to 200 parts of single cream; the compound thickening emulsifier is prepared from gelatin, agar, locust bean gum and lactic acid glycerol fatty acid ester according to the weight ratio of (10 to 25): (1 to 5): (2 to 8): (2 to 10); the fermentation agent is 150 to 250 U / T, and the fermentation agent comprises streptococcus salivarius subsp. Thermophilus, lactobacillus delbrueckii subsp. Bulgaricus, lactobacillus plantarum and lactococcus lactis subsp. Cremoris; the compound biological enzyme comprises lipase, glutamine transaminase and lactase. The aerated fermented milk which is fluffy, smooth and soft in texture is obtained, the obtained aerated fermented milk contains high viable count, the tissue state is stable within the shelf life, no gas overflows, and the aerated fermented milk has the sour and sweet taste of the fermented milk and the soft mousse cake taste.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

The present invention provides a phytosphingosine-producing strain of Streptococcus salivarius subsp. thermophilus, as well as its preparation method and application. The strain, Streptococcus salivarius subsp. thermophilus, was deposited with the Guangdong Provincial Microbiological Culture Collection on March 10, 2025, with accession number GDMCC 65992. The deposit address is: 5th Floor, Building 59, No. 100, Xianlie Middle Road, Guangzhou, Guangdong Province. Streptococcus salivarius subsp. thermophilus has the advantage of effectively increasing the phytosphingosine content in dairy products.

The invention discloses an intestinal flora marker related to a children inflammatory bowel disease, a product and application of the intestinal flora marker. The intestinal flora marker disclosed by the invention is one or more of streptococcus salivarius, bacteroides ovatus, bacteroides vulgaris, clostridium altaicum, actinomycetes decayed tooth and clostridium difficile, and can be applied to prediction and diagnosis of patients with the inflammatory bowel disease in children, the diagnosis process is completely noninvasive, and the accuracy is high.

The invention belongs to the technical field of dairy products, and particularly relates to high-water-retention solidified yogurt as well as a preparation method and application thereof. The preparation raw materials of the set yogurt with high water-retaining property comprise raw milk, a cheese product, concentrated whey protein powder, yolk powder and a leavening agent. The leavening agent comprises lactobacillus delbrueckii subsp. Bulgaricus, streptococcus salivarius subsp. Thermophilus, bifidobacterium animalis subsp. Lactis and lactobacillus acidophilus. The cheese product, the concentrated whey protein powder and the yolk powder are taken as core functional raw materials and form a synergistic effect, so that the yoghourt has good water-retaining property, sensory evaluation and storage stability. Meanwhile, by compounding the four strains, the water-retaining property, the storage stability, the taste, the tissue state and the like of the yoghourt can be improved.

An oat preparation, an oat product comprising the oat preparation, a preparation method therefor and the use thereof. The oat preparation is obtained by fermenting a fermentation broth; the fermentation broth comprises a fermentation substrate and a starter culture; the fermentation substrate mainly consists of hydrolyzed oat bran; the starter culture comprises lactobacillus reuteri, lactobacillus plantarum, lactobacillus acidophilus, bifidobacterium lactis and lactobacillus rhamnosus, and comprises streptococcus salivarius subsp. thermophilus and lactobacillus delbrueckii subsp. bulgaricus.

The invention provides a probiotic for enhancing immunity, a probiotic agent and a dairy product. The probiotic for enhancing immunity consists of a bifidobacterium animalis subsp. Lactis IU100 strain and a streptococcus salivarius subsp. Thermophilus ST06 strain. The invention creatively develops a brand-new probiotic compounding mode and a brand-new strategy for improving the immunity of the organism, that is, the bifidobacterium animalis subsp. Lactis IU100 strain and the streptococcus salivarius subsp. Thermophilus ST06 strain are combined for use, and the bifidobacterium animalis subsp. Lactis IU100 strain and the streptococcus salivarius subsp. Thermophilus ST06 strain are found to be matched and promoted with each other and have a synergistic effect in the aspect of improving the immunity of the organism; under the condition that the using amount of the bacteria is consistent, compared with a strain intervention mode without any bacteria, the effect of compounding the two bacteria in the aspect of improving the immunity of the organism is remarkably improved.

The invention belongs to the technical field of microorganisms, and relates to a streptococcus salivarius subsp. Thermophilus Ss-PG-10 strain for relieving hyperuricemia and a preparation method of the streptococcus salivarius subsp. Thermophilus Ss-PG-10 strain. The strain provided by the invention is streptococcus salivarius subsp. Thermophilus Ss-PG-10, the classification name of the strain is Streptococcus salivarius subsp. Thermophilus, and the preservation number of the strain is CGMCC (China General Microbiological Culture Collection Center) No. 31867. The streptococcus salivarius subsp. Thermophilus Ss-PG-10 is separated from pickled Chinese cabbages, has a function of relieving hyperuricemia, has a certain antibacterial effect on pathogenic bacteria such as staphylococcus aureus, bacillus subtilis and escherichia coli, and has relatively strong acid resistance, cholate resistance and artificial simulated gastrointestinal fluid resistance.

The present invention relates to an Alzheimer's disease marker and risk prediction model based on intestinal flora. The Alzheimer's disease marker based on intestinal flora includes intestinal flora, and the intestinal flora includes anaerobic Lawsonia sibiricum, Escherichia coli, Streptococcus salivarius, Asahidiella pseudomallei, Kluyveromyces pedis, intestinal Roseburia, Roseburia faecalis, Roseburia hominis, Firmicutes CAG424 bacteria and Clostridium CAG58 bacteria. The present invention mines Alzheimer's disease markers based on intestinal flora and further constructs an Alzheimer's disease risk prediction model based on intestinal flora, which has the characteristics of high detection accuracy, convenience, speed, safety and non-invasiveness, and has important clinical guidance significance for assisting the diagnosis of Alzheimer's disease-related indicators.

The invention discloses a high-salt-resistant cheese composite leavening agent and application thereof, and belongs to the technical field of fermented dairy products. The strains in the high-salt-resistant cheese compound leavening agent comprise leuconostoc mesenteroides subsp. Mesenteroides JMCC0041, lactococcus lactis subsp. Cremoris JMCC0035, lactococcus lactis subsp. Lactis JMCC0036 and streptococcus salivarius subsp. Thermophilus JMCC16, the leavening agent is resistant to high-salt conditions, the fermentation speed is appropriate, when the leavening agent is used for fermenting cheese products, the obtained fermentation products are low in peculiar smell and bitter taste, and the fermentation effect is good. The content of butanedione in the cheese is high and appropriate, and the cream fragrance is prominent. The method is suitable for cheese fermentation production.

The invention discloses a sheep colostrum composition capable of improving sleep and application of the sheep colostrum composition, and belongs to the technical field of microbial fermentation and functional food. The core of the invention lies in that a composite leavening agent is compounded by using the casei paracasei GP66 and the streptococcus salivarius subsp. Thermophilus HX-ST36, and then the sheep colostrum of concentrated whey protein, galactooligosaccharide and acerola cherry powder is subjected to synergistic fermentation. According to the fermentation process, IgG in sheep colostrum can be efficiently reserved, and the content of small molecule peptide and gamma-aminobutyric acid in a fermentation system is remarkably increased. Meanwhile, the invention also generates a novel pentapeptide, the pentapeptide has a sleep aiding effect, and the amino acid sequence of the pentapeptide is Arg-Phe-Leu-Trp-Pro (RFLWP). Animal experiments prove that the traditional Chinese medicine composition can play a role in improving sleep by regulating a neurotransmitter system. The invention provides a new way of a product for improving sleep, which is natural, safe and clear in mechanism.

The invention relates to a microbubble drinking type tea yoghourt and a preparation method thereof, and the preparation method comprises the following steps: mixing tea juice, lemon juice, sodium citrate, raw milk and sugar, sterilizing, inoculating with a complex microbial inoculant for fermentation, and demulsifying to obtain the microbubble drinking type tea yoghourt, the strains in the complex microbial inoculant comprise a combination of streptococcus salivarius subsp. Thermophilus, lactococcus lactis subsp. Diacetyl, plant lactobacillus and leuconostoc mesenteroides subsp. Mesenteroides. In the invention, a complex microbial inoculant of four specific microbial strains is adopted to ferment the dairy product, and the four strains are further found to have a synergistic effect, so that the tissue state, the taste, the smell and the overall fusion effect of the tea yoghourt product prepared by final fermentation are further improved; the microbubble tea yoghourt beverage with excellent taste and stable tissue state is prepared.

The invention discloses streptococcus salivarius subsp. Thermophilus for improving the content of host collagen by regulating and controlling the anabolism of collagen and a metaplasm thereof, and belongs to the technical field of microorganisms and the technical field of medicines. The metagen of the streptococcus salivarius subsp. Thermophilus CCFM1464 provided by the invention has a good effect of increasing the collagen content, maintains the stable collagen structure, and improves the moisture and elasticity of skin, specifically, a thallus lysate promotes the content of COLIII of HSF cells and the enzyme activity of LH1, LOX and P4H in vitro, and can improve the enzyme activity of LH1 in vitro from fermentation of supernate, so that the skin elasticity is improved. The enzyme activity of the MMP-1 is inhibited; by orally taking the inactivated thallus, the enzyme activity of MMP-1 can be inhibited, the enzyme activity of P4H and LOX and the enzyme activity of GSH-PX can be increased, meanwhile, the content of TGF-beta can be increased, and the content of CRP can be reduced; the content of CRP, IL-6 and TNF-alpha can be reduced by oral administration of the self-fermentation supernatant.