86 results about "Staphylococcus salivarius" patented technology

The invention belongs to the technical field of microorganisms, and provides streptococcus salivarius subsp. Thermophilus HX-ST36, and the preservation number of the streptococcus salivarius subsp. Thermophilus HX-ST36 is CGMCC NO.32955. The streptococcus salivarius subsp. Thermophilus provided by the invention can be used for fermenting astragalus membranaceus-angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrheal model mouse, a fermentation product can remarkably inhibit the writhing reaction, and the effects of relieving dysmenorrheal and enriching blood can be achieved by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the content of hemoglobin (HGB). The dampness clearing effect of the fermentation product is verified by improving the heavy physical sign of moisture through crowd experiments. The invention also provides a preparation method of the probiotic preparation and the probiotic fermentation product. The preparation methods of the probiotic preparation and the probiotic fermentation product are simple, and large-scale production can be realized.

The invention belongs to the field of molecular biological detection, and provides a joint detection composition which is mainly used for detecting related pathogens by using a multiple fluorescent PCR (Polymerase Chain Reaction) analysis method. Therefore, at least four of staphylococcus aureus, staphylococcus capitis, bacteroides fragilis, streptococcus agalactiae, streptococcus salivarius and staphylococcus hominis are detected and distinguished in a single-tube reaction system at the same time. Meanwhile, the detection sensitivity of the composition is higher and reaches 200 copies / mL, and the detection is more accurate.

The invention discloses an intestinal flora marker related to juvenile depression, a product and application of the intestinal flora marker. The intestinal flora marker is prepared from any one or more of prokaryotic streptococcus parahaemolyticus, streptococcus salivarius, Alistipep and Lacnospiraceae, and the intestinal flora marker is prepared from any one or more of prokaryotic streptococcus parahaemolyticus, streptococcus salivarius, Alistipep and Lacnospiraceae, and the intestinal flora marker is prepared from any one or more of the prokaryotic streptococcus parahaemolyticus, the streptococcus salivarius, the Alistipep and the Lacnospiraceae, the prokaryotic streptococcus parahaemolyticus, the Streptococcus salivarius, the Alistipep and the Lacnospiraceae. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal flora marker. The invention provides a product for diagnosing juvenile depression and a computer program product related to the juvenile depression. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of depression of teenagers, and provides a new tool for clinical diagnosis.

The invention discloses streptococcus salivarius subsp. Thermophilus JMCC0040 for preparing Greek yogurt and application of the streptococcus salivarius subsp. Thermophilus JMCC0040, and belongs to the technical field of microbial engineering. The streptococcus salivarius subsp. Thermophilus JMCC0040 strain is preserved in the China General Microbiological Culture Collection Center, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, the preservation date is February 1, 2024, the preservation number is CGMCC NO.29835, and the Latin name is Streptococcus salivarius subsp. Thermophilus. The streptococcus salivarius subsp. Thermophilus JMCC0040 strain is named as Streptococcus salivarius subsp. Thermophilus. The streptococcus salivarius subsp. Thermophilus JMCC0040 for preparing the Greek yogurt, provided by the invention, has the advantages of good fermentation characteristic, high fermentation speed, weak post-acidity, low pink feeling of a fermented dairy product, high smoothness and good texture, and is suitable for preparing the Greek yogurt with higher requirements on fermentation strains.

The invention discloses a preparation method of high-stability beta-glucan yoghourt. Mixing the sterilized fresh milk with a composite strain consisting of lactobacillus delbrueckii subsp. Bulgaricus, streptococcus salivarius subsp. Thermophilus, bifidobacterium animalis subsp. Lactis, plant lactobacillus, bifidobacterium breve, lactobacillus paracasei, lactobacillus helveticus, lactobacillus rhamnosus and bifidobacterium longum subsp. Longum, and fermenting; and adding beta-glucan into the fermented yoghourt to obtain the high-stability beta-glucan yoghourt. Before beta-glucan is added, the compound bacterial strain is added into the milk, protein in the milk can be gathered under the action of the compound bacterial strain to form a three-dimensional curd network, so that the flowability of a system is reduced, then glucan is added, and the glucan can be uniformly dispersed in curd gaps, so that the glucan is prevented from being excessively combined with the protein in the milk; the stability of a yoghourt system is improved.

The invention relates to the technical field of microorganisms, in particular to space breeding combined lactobacillus salivarius ZK-88-S and application thereof. The combined lactobacillus salivarius ZK-88-S disclosed by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 24, 2024, and the preservation number is CGMCC No.33181; the combined lactobacillus salivarius ZK-88-S can inhibit escherichia coli, staphylococcus aureus, candida albicans, pseudomonas aeruginosa, fusobacterium nucleatum, porphyromonas gingivalis, streptococcus mutans, streptococcus salivarius, streptococcus gordoni or actinomyces naessii, and can be applied to preparation of medicines, daily necessities or health-care foods for oral treatment and oral cleaning.

The invention provides application of polypeptide or related biological materials thereof in serving and / or preparing products for regulating oral micro-ecological balance. The polypeptide with the amino acid sequence as shown in SEQ ID NO: 1 or related biological materials thereof can selectively inhibit harmful bacteria (such as streptococcus mutans) in the oral cavity, and also can ensure normal physiological activities of probiotics (such as streptococcus sanguis, streptococcus salivarius, streptococcus gordoni and the like) in the oral cavity, so that the regulation of micro-ecological balance of the oral cavity is realized, and the oral health of a human body is ensured.

The invention discloses a meningioma enteric microbial marker, a product and application of the meningioma enteric microbial marker, and belongs to the field of biological medicine. The invention relates to an enteric microbial marker, which is characterized by being prepared from one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and is characterized in that the enteric microbial marker comprises one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and the enteric microbial marker comprises one or more of parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal microbial marker. The invention provides a product for diagnosing meningioma and a computer program product related to meningioma. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of meningioma, and provides a new tool for clinical diagnosis.

The invention belongs to the field of molecular biological detection, and provides a joint detection composition which mainly utilizes a multiple fluorescent PCR analysis method to detect related pathogens, so that detection and distinguishing of at least four of clostridium praerzii, eubacterium rectum, streptococcus salivarius, clostridium tenella, prevotella and escherichia coli are simultaneously realized in a single-tube reaction system. Meanwhile, the detection sensitivity of the composition is higher and reaches 500 copies / mL, and the detection is more accurate.

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

The invention relates to an Alzheimer's disease marker based on intestinal flora and a risk prediction model. The Alzheimer's disease marker based on the intestinal flora comprises the intestinal flora, wherein the intestinal flora comprises anaerobic lawsonia pasteurianus, escherichia coli, streptococcus salivarius, assa wig, clostridium luviergii, intestinal rosebawii, rosella faecalis, human rosella, trichothecium CAG424 and clostridium CAG58. The invention further discloses a preparation method of the alzheimer's disease marker based on the intestinal flora, and the alzheimer's disease marker based on the intestinal flora comprises the intestinal flora and an application of the alzheimer's disease marker based on the intestinal flora. The Alzheimer's disease marker based on the intestinal flora is excavated, the Alzheimer's disease risk prediction model based on the intestinal flora is further constructed, and the method has the advantages of being high in detection accuracy, convenient, rapid, safe and noninvasive and has important clinical guiding significance in auxiliary diagnosis of Alzheimer's disease related indexes.

The present invention provides FPR2 agonists. Specifically, an outer membrane vesicle derived from at least one type of lactic acid bacteria selected from the group consisting of the genus Lactobacillus, the genus Lactobacillus casei, the genus Lactobacillus plantarum, the genus Lactobacillus conjuncticus, the genus Lactococcus, and the subsp. Thermophilus of Streptococcus salivarius is compounded as an active ingredient of the FPR2 agonist, and a method for preparing the FPR2 agonist containing the outer membrane vesicle derived from the outer membrane vesicle derived from at least one type of lactic acid bacteria derived from the outer membrane vesicle derived from the at least one type of lactic acid bacteria.

The invention relates to the technical field of food, and particularly discloses yoghourt as well as a preparation method and application thereof. The invention provides a preparation method of yoghurt, the yoghurt is prepared by fermenting a substrate through zymophyte, the substrate comprises a milk base material and protease, and the milk base material comprises concentrated animal milk and a fat raw material; the milk base material is subjected to lipase enzymolysis before fermentation and then is used for fermentation; the protease comprises flavourzyme or further comprises neutral protease; the fat raw material comprises one or more of cream cheese, fermented butter and single cream; the zymophyte is composed of lactobacillus helveticus, lactococcus lactis subsp. Lactis (diacetyl type), lactococcus lactis subsp. Cremoris, streptococcus salivarius subsp. Thermophilus and lactobacillus delbrueckii subsp. Bulgaricus. The content of flavor substances in the yoghourt can be increased, and the quality of the yoghourt is improved.

The invention relates to a lactic acid bacteria product, a preparation method thereof and application of the lactic acid bacteria product in food preservation, and the lactic acid bacteria product comprises fermentation metabolites obtained by co-fermentation of lactobacillus plantarum, lactobacillus delbrueckii subsp. Lactis and streptococcus salivarius subsp. Thermophilus and plant extracts. The lactobacillus and the streptococcus salivarius subsp. Thermophilus are scientifically proportioned and combined, and the plant extract with a natural antibacterial effect is added, so that the antibacterial efficiency is synergistically improved, the fresh-keeping effect is enhanced, meanwhile, the nutritional value of the food can be improved, and the probiotic function is increased.

The invention belongs to the field of oral care products, and discloses a raw Pu'er tea extract as well as a preparation method and application thereof, the preparation method of the raw Pu'er tea extract comprises the following steps: S1, crushing raw Pu'er tea into powder, sieving to obtain raw Pu'er tea powder, adding water for dissolving, and sterilizing to obtain raw Pu'er tea liquid; s2, inoculating compound bacteria into the Pu'er raw tea liquid, adding cellulase and pectinase at the same time, and fermenting for 36-60 hours; and S3, carrying out sterilization and enzyme deactivation treatment on the fermentation liquor, centrifuging, collecting supernate, and preparing freeze-dried powder, so as to obtain the Pu'er raw tea extract. The compound bacteria comprise bacillus velezensis MRS and streptococcus salivarius QS-20. The raw Pu'er tea extract is safe, healthy and free of side effects, has a good antibacterial effect on streptococcus mutans and can be used as an active ingredient for preparing anti-caries antibacterial medicines, oral washing products or oral care products, and the preparation method can obviously improve the yield of the antibacterial active ingredient and can be applied to industrial production.

The invention discloses an application of a streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet in preparation of a product for treating otitis media. The preservation number of the streptococcus salivarius subsp. Thermophilus Biohalo 23 is DSM34540; the streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet can relieve the disease symptoms of otitis media and reduce the morbidity of the otitis media, has a remarkable curative effect on the otitis media, and particularly, through clinical tests, the number of diseases of infants can be remarkably reduced, the morbidity of the infants can be reduced, middle ear effusion can be improved, and the curative effect of the infants on the otitis media can be improved. Therefore, the streptococcus salivarius subsp. Thermophilus Biohalo 23 tablet disclosed by the invention can be used for treating the otitis media.

Provided are Streptococcus salivarius and compositions comprising Streptococcus salivarius for the treatment of ENT diseases, in particular cancer therapy-induced oral mucositis and respiratory tract infections associated with cancer therapy.

The present invention relates to a bacterial strain of Streptococcus salivarius with oral probiotic properties and a minimum inhibitory concentration of at least 500 ppm.

This invention belongs to the field of fermentation inoculant screening and preparation technology, specifically relating to a method for screening strain combinations for preparing mozzarella cheese, the strain combinations themselves, and their applications. The method of this invention systematically evaluates the fermentation kinetics, texture-forming ability, and flavor characteristics of *Streptococcus salivarius* subspecies *thermophilic*, establishing a dynamic ratio screening method to optimize the strain ratio of *Streptococcus salivarius* subspecies *thermophilic*, thereby improving the product quality and batch stability of mozzarella cheese. This method is particularly suitable for solving textural defects or flavor imbalances caused by improper strain ratios in industrial production, providing technical support for the production of highly consistent mozzarella cheese, and can be widely applied in the processing of cheese products, pizzas, and other frozen foods.

The invention belongs to the technical field of health-care products, and particularly relates to a probiotic composition for improving health of an oral cavity and an upper respiratory tract and a preparation method of the probiotic composition. Oral health is an important component of whole body health. Bacterial infections in the oral cavity, such as caries and periodontal diseases, not only influence the oral cavity, but also possibly harm the whole body health and influence the quality of life. The oral cavity is a portal of the respiratory tract, and bad oral hygiene may cause the accumulation of tartar, plaque, soft dirt and the like in the oral cavity and becomes a repository of pathogenic bacteria of the respiratory tract. When the immunity is low, the bacteria may enter the lung through the respiratory tract to cause respiratory tract and even lung infection. The invention discloses a probiotic composition for improving health of oral cavity and upper respiratory tract, which has the effects of resisting inflammation, resisting infection, preventing decayed teeth, protecting oral mucosa, preventing and treating bad breath and the like through the synergistic effect of streptococcus salivarius subsp. Thermophilus K12, lactobacillus rhamnosus CRL1505, lactobacillus salivarius NHNK612, lactobacillus mucus NHNK606 and the like.

The present invention provides an FPR2 agonist. Specifically, the FPR2 agonist comprises, as an active ingredient, outer membrane vesicles derived from at least one lactic acid bacterium selected from the group consisting of genus Lactobacillus, genus Lacticaseibacillus, genus Lactiplantibacillus, genus Ligilactobacillus, genus Lactococcus, and Streptococcus salivarius subsp. thermophilus.

Disclosed are a novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain, a composition containing the same for prevention or alleviation of an oral disease, and oral probiotics, and specifically, the novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain can prevent, treat, and alleviate periodontal diseases through strong antibacterial and antiinflammatory activities against periodontal disease-causing strains, prevents, treat, and alleviates dental caries through strong antibacterial activity against dental caries-causing strains and biofilm formation inhibitory ability, and suppress halitosis caused by oral diseases, thereby contributing to oral health improvement.

The present invention relates to a newly isolated bacterial strain of the species Streptococcus salivarius (S. salivarius). More specifically, the S. salivarius strain was deposited at the BCCM under accession number LMG P-31813. Furthermore, the present invention relates to a composition comprising the isolated bacterial strain of the species S. salivarius. In another aspect, the present invention further relates to the isolated bacterial strain of the present invention or the composition of the present invention for use in immunomodulation and / or treatment and / or prevention of infection or disease.

The application discloses a kind of adolescent autism intestinal microorganism marker and application thereof, belong to the field of biological medicine.The microorganism marker includes one or more of Ruminococcus gnavus, Streptococcus thermophilus, Streptococcus salivarius, Butte's intestinal bacillus, pet big anaerobic clavulanic acid bacteria and Prevotella pittmanniae.The application provides a kind of product (such as kit), including detection reagent for detecting the relative abundance of the microorganism marker.The product provided by the application has good feasibility and accuracy, and can effectively evaluate whether adolescent has the risk of autism, provides a new tool for clinical diagnosis.

The invention belongs to the field of microorganisms, and particularly relates to lactobacillus paracasei with multi-matrix fermentation capacity and application of the lactobacillus paracasei. The lactobacillus paracasei is lactobacillus paracasei Shannan.LPA-972, and the preservation number of the lactobacillus paracasei Shannan.LPA-972 is CCTCC (China Center For Type Culture Collection) NO: M 20242026. The lactobacillus paracasei is lactobacillus paracasei Shannan.LPA-972. The lactobacillus paracasei is related to a phosphoenolpyruvate-glycotransferase system carried by the lactobacillus paracasei. When the fermentation agent containing lactobacillus paracasei, lactobacillus delbrueckii subsp. Lactis and streptococcus thermophilus subsp. Salivarius with a specific viable count ratio is used for fermenting plant milk and animal milk, broad-spectrum adaptability of animal milk raw materials and plant milk raw materials is achieved, meanwhile, the nutrition and sensory quality of fermentation products are remarkably improved, the problem of multi-matrix fermentation can be effectively solved, and the production cost is reduced. And the process cost and complexity of a dairy product production end are effectively reduced.

The invention provides a streptococcus salivarius subsp. Thermophilus for producing phytosphingosine, a preparation method and application, the strain is streptococcus salivarius subsp. Thermophilus, the strain is preserved in the Guangdong Microbial Culture Collection Center on March 10, 2025, the preservation number is GDMCC 65992, and the preservation address is the 5th floor, No. 59 building, No. 100 Courtyard, Xianlie Middle Road, Guangzhou City, Guangdong City. The streptococcus salivarius subsp. Thermophilus has the advantage that the content of phytosphingosine in dairy products can be effectively increased.

The application discloses a Streptococcus salivarius CCFM1512 which can inhibit excessive inflammatory response and relieve periodontitis, and belongs to the technical field of microorganisms. The fermentation supernatant of the Streptococcus salivarius provided by the application can relieve inflammation of human gingival fibroblasts induced by Porphyromonas gingivalis lipopolysaccharide in vitro, and can significantly reduce the expression of inflammatory factors such as IL-1beta, IL-6 and IL-17A in gingival tissues, regulate the M1 / M2 polarization balance of macrophages and restore the expression level of DEL-1, so as to relieve alveolar bone absorption of rats. The Streptococcus salivarius has a great application prospect in the aspects of regulating oral inflammatory response and preparing products for relieving periodontitis.

The invention relates to the technical field of fermented dairy products, and discloses a fermented animal and plant double-protein aerated mousse and a preparation method thereof, and the aerated mousse is prepared from the following raw materials by weight: 300-700 parts of animal milk; 100 to 500 parts of plant milk; 40 to 100 parts of a sweetening agent; 100 to 200 parts of single cream; the compound thickening emulsifier is prepared from gelatin, agar, locust bean gum and lactic acid glycerol fatty acid ester according to the weight ratio of (10 to 25): (1 to 5): (2 to 8): (2 to 10); the fermentation agent is 150 to 250 U / T, and the fermentation agent comprises streptococcus salivarius subsp. Thermophilus, lactobacillus delbrueckii subsp. Bulgaricus, lactobacillus plantarum and lactococcus lactis subsp. Cremoris; the compound biological enzyme comprises lipase, glutamine transaminase and lactase. The aerated fermented milk which is fluffy, smooth and soft in texture is obtained, the obtained aerated fermented milk contains high viable count, the tissue state is stable within the shelf life, no gas overflows, and the aerated fermented milk has the sour and sweet taste of the fermented milk and the soft mousse cake taste.

The application belongs to the technical field of microorganisms, and provides a Streptococcus salivarius subsp. thermophilus HX-ST36, which has a preservation number of CGMCC NO. 32955. The Streptococcus salivarius subsp. thermophilus provided by the application can ferment Astragalus membranaceus Bunge-Angelica sinensis. In a cold coagulation and blood stasis type primary dysmenorrhea model mouse, the fermentation product thereof can significantly inhibit the writhing response, and can realize the effects of relieving dysmenorrhea and tonifying blood by reducing the levels of prostaglandin PGF2 and vasopressin ADH in uterine tissue and increasing the hemoglobin (HGB) content. The effect of the fermentation product in removing dampness is verified by improving the dampness signs of a crowd. The application further provides a probiotic preparation and a preparation method of a probiotic fermentation product. The preparation method of the probiotic preparation and the probiotic fermentation product is simple and can be produced on a large scale.

The present invention provides a phytosphingosine-producing strain of Streptococcus salivarius subsp. thermophilus, as well as its preparation method and application. The strain, Streptococcus salivarius subsp. thermophilus, was deposited with the Guangdong Provincial Microbiological Culture Collection on March 10, 2025, with accession number GDMCC 65992. The deposit address is: 5th Floor, Building 59, No. 100, Xianlie Middle Road, Guangzhou, Guangdong Province. Streptococcus salivarius subsp. thermophilus has the advantage of effectively increasing the phytosphingosine content in dairy products.