The invention relates to the technical field of bathroom devices, and discloses a sanitary splash-proof closestool. The sanitary splash-proof closestool comprises a closestool body with a water seal and a closestool ring, wherein a driving piece is arranged at the upper end of the closestool body, the driving piece is communicated with a communication cavity, the communication cavity is communicated with a control cavity through an air faucet, the upper portion of the control cavity is communicated with a moving cavity, and a driving piston is installed in the moving cavity. Air pressure changes generated when a user sits on the closestool or leaves from the closestool drive a splash-proof piece to emerge from a water surface or sink below the water surface, therefore, when the user uses the closestool, the splash-proof piece emerges from the water surface to receive falling excrement, due to blocking of a wing slice of the splash-proof piece, kinetic energy is horizontally released, and the problem that sewage splashes to the hips is effectively solved. The using experience of people and the sanitary conditions are improved, the design and production difficulty of the water seal of the closestool is further reduced, and convenience is brought to selection of people; further, the design size of the water seal is increased, less excrement adheres to the inner wall of the closestool, and the closestool is cleaner and more sanitary.