The invention relates to a multi-dimensional seismic isolation support based on vertical variable stiffness and horizontal self-return. The support is mainly composed of a sleeve component, a lower connecting plate, a side coaming, concrete, an upper connecting plate and SMA self-return assemblies; under strong vertical seismic excitation, an inner core is bent, and the vertical rigidity of the support is greatly reduced so as to realize seismic isolation; in the horizontal direction, lantern rings are welded to the upper portion of the inner core, the lantern rings are connected through the SMA self-return assemblies, the lantern rings are connected with the side coaming through the SMA self-return assemblies, a structural seismic isolation layer can laterally move to a certain degree toachieve horizontal seismic isolation, and returning can be achieved through the SMA self-return assemblies after lateral movement; and a sensor can be arranged at the position where the inner core possibly makes contact with an outer pipe so as to monitor the working state of the support. Compared with the prior art, the support realizes multi-dimensional seismic isolation through the rigidity change after a pressing rod is bent and the characteristic of self-return after horizontal lateral movement, is suitable for structural multi-dimensional seismic isolation with a vertical vibration control function, and has the characteristics that the structure is simple, the cost is relatively low, and the reliability is relatively high.