The embodiment of the invention provides an electrostatic discharge protection circuit. The electrostatic discharge protection circuit comprises a first power supply, a second power supply, a first electrostatic discharge protection device, a second electrostatic discharge protection device, a first ground electrically connected with the first power supply, and a second ground electrically connected with the second power supply, the first power supply and the second power supply are mutually independent, the first ground and the second ground are electrically connected through the first electrostatic discharge protection device, and the first ground and the second power supply are electrically connected through the second electrostatic discharge protection device. Therefore, the first electrostatic discharge protection device and the second electrostatic discharge protection device are added to first improve the ESD performance, the electrostatic discharge protection devices are manufactured according to the existing process, the size is not adjusted, only the device is increased, the area of an integrated circuit is increased, the cost increase can be ignored, and the cost of the integrated circuit is effectively saved.